Frontiers in Clinical Drug Research - HIV.

Cover -- Title -- Biblography -- End User License Agreement -- Contents -- Preface -- List of Contributors -- Design and Synthesis of HIV-1 Protease Inhibitors -- Sesha S. Alluri and Ashit K. Ganguly* -- INTRODUCTION -- Entry Inhibitors -- Nucleoside Reverse Transcriptase Inhibitors (NRTIs) -- Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) -- Integrase Inhibitors -- HIV-1 Protease Inhibitors-Structure Based Drug Design -- Binding Site -- Design of Novel Conformationally Restricted Sulfonamides -- CONCLUSION -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Potential Magnetic Nanotherapeutics for Management of neuroAIDS -- Vidya Sagar*, Arti Vashist and Madhavan Nair* -- MECHANISMS OF NEUROAIDS -- CHALLENGES OF BLOOD-BRAIN BARRIER (BBB) FOR NEUROAIDS TREATMENTS -- ADVANTAGES OF NANOTHERAPEUTICS FOR MANAGEMENT OF NEUROAIDS -- MAGNETIC NANOTHERAPEUTICS FOR MANAGEMENT OF NEUROAIDS -- CONTROLLED RELEASE MAGNETIC NANOFORMULATIONS FOR NEUROAIDS -- CHALLENGES AND PROSPECTS OF MAGNETIC NANOFORMULATIONS FOR NEUROAIDS -- CONCLUSION -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Syntheses of FDA Approved Integrase Inhibitor HIV Drugs and Improved Manufacturing using Flow Processing -- Omobolanle Janet Jesumoroti, Faith Akwi and Paul Watts* -- INTRODUCTION -- BATCH SYNTHESIS OF FDA APPROVED HIV INTEGRASE INHIBITORS -- RALTEGRAVIR -- Background -- Synthesis of Raltegravir -- ELVITEGRAVIR -- Background -- Synthesis of Elvitegravir -- DOLUTEGRAVIR -- Background -- Synthesis of Dolutegravir -- BICTEGRAVIR -- Background -- Synthesis of Bictegravir -- ORGANIC SYNTHESIS IN THE PHARMA INDUSTRY -- Background -- CONTINUOUS FLOW PROCESSING AND THE PHARMA INDUSTRY -- APPLICATION OF CONTINUOUS FLOW PROCESSING IN HIV/AIDS DRUGS AND APIS SYNTHESIS.

CONTINUOUS FLOW SYNTHESIS OF NEVIRAPINE PRECURSOR -- CONTINUOUS FLOW SYNTHESIS OF DOLUTEGRAVIR -- CONTINUOUS FLOW SYNTHESIS OF EFAVIRENZ AND ITS INTERMEDIATES -- SEMI-CONTINUOUS FLOW SYNTHESIS OF LAMIVUDINE -- CONTINUOUS FLOW SYNTHESIS OF INTERMEDIATES TOWARDS DARUNAVIR AND ATAZANIVIR -- CONCLUSION -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- The Development and Clinical Progress on Chemokine Receptor-Based HIV Entry Inhibitors -- Yi-Qun Kuang* -- INTRODUCTION -- I. THE ROLE OF HIV-1 CO-RECEPTORS IN VIRAL REPLICATION -- II. ANTAGONIST-BASED ON DIFFERENT MECHANISMS -- ANTAGONISTS BASED ON-CCR5 -- The Biology of CCR5 -- CCR5 antagonists -- a). Maraviroc -- b). Cenicrivivoc -- c). INCB-9471 -- d). Monomeric DAPTA (mDAPTA) -- e). Vicriviroc -- f). PRO140 -- ANTAGONISTS BASED ON-CXCR4 -- The Biology of CXCR4 -- CXCR4 Antagonists -- AMD3100 -- AMD-070 -- NOVEL ANTAGONISTS BASED ON CO-RECEPTOR-INTERACTING PROTEINS -- NHERF1 -- DRiP78 -- CONCLUSION -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Sexually Transmitted Co-infections in Persons Living with HIV -- Ana Paula Ferreira Costa, Marcos Gonzaga dos Santos and Ricardo Ney Oliveira Cobucci* -- 1. HIV - BACKGROUND -- 2. VIRAL GENITAL INFECTIONS -- 2.1. Human Papillomavirus (HPV) -- 2.2. Herpes Simplex Vírus (HSV) -- 3. BACTERIAL GENITAL INFECTIONS -- 3.1. Syphilis -- 3.2. Chlamydia trachomatis -- 3.3. Neisseria gonorrhoeae -- 4. OTHER GENITAL INFECTIONS -- 4.1. Trichomonas vaginalis -- CONCLUSION -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENT -- REFERENCES -- Subject Index -- Back Cover.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.