Reproductive Endocrinology for the MRCOG and Beyond.

Cover -- Published titles in the MRCOG and Beyond series -- Contents -- Acknowledgments -- Preface to the first edition -- Preface to the second edition -- Abbreviations -- 1. Sexual differentiation: intersex disorders -- Development of the internal and external genitalia -- Origin of the ovaries and oocytes -- Origin of the uterus and fallopian tubes -- Development of external genitalia -- NEWBORN APPEARANCE -- Disorders of development of internal andexternal genitalia -- MULLERIAN DUCT ABNORMALITIES -- CONGENITAL ABSENCE OF THE VAGINA -- FUSION ABNORMALITIES OF THE VAGINA -- MULLERIAN/UTERINE ANOMALIES -- Androgen insensitivity syndrome -- 5-ALPHA REDUCTASE DEFICIENCY -- Congenital adrenal hyperplasia -- Cloacal anomalies -- Management of intersex conditions -- Reference -- 2. Adrenal disorders -- The adrenal medulla -- EFFECTS OF ADRENALINE AND NORADRENALINE -- PHAEOCHROMOCYTOMA -- The adrenal cortex -- HYPERFUNCTION OF THE ADRENAL CORTEX -- 3. Normal puberty and adolescence -- Pubertal development -- ONSET OF PUBERTAL DEVELOPMENT -- References -- 4. Abnormal puberty -- Precocious puberty -- TRUE PRECOCIOUS PUBERTY -- PREMATURE THELARCHE -- THELARCHE VARIANT -- PREMATURE ADRENARCHE -- CONGENITAL ADRENAL HYPERPLASIA -- PERIPHERAL TUMOURS -- MANAGEMENT OF PRECOCIOUS PUBERTY -- CONSTITUTIONAL DELAY OF GROWTH AND PUBERTY -- TURNER SYNDROME -- POLYGLANDULAR AUTOIMMUNE SYNDROMES -- CONGENITAL HYPOGONADOTROPHIC HYPOGONADISM -- MANAGEMENT OF DELAYED PUBERTY -- Delayed puberty -- CONSTITUTIONAL DELAY OF GROWTH AND PUBERTY -- TURNER SYNDROME -- POLYGLANDULAR AUTOIMMUNE SYNDROMES -- CONGENITAL HYPOGONADOTROPHIC HYPOGONADISM -- MANAGEMENT OF DELAYED PUBERTY -- Reference -- 5. The menstrual cycle -- Ovulation during the perimenopausal transition -- References -- 6. Disorders of menstruation -- Normal menstruation -- VARIATION IN MENSTRUAL BLOOD LOSS.

VARIATION IN CYCLE LENGTH AND DURATION OF MENSTRUATION -- The abnormal menstrual cycle -- MENORRHAGIA -- ASSESSMENT OF MENSTRUAL BLOOD LOSS -- CAUSES OF MENORRHAGIA -- DIAGNOSIS OF MENORRHAGIA -- Methods of endometrial assessment -- ENDOMETRIAL BIOPSY -- HYSTEROSCOPY -- TRANSVAGINAL ULTRASOUND -- Initial management of menorrhagia in primary care -- Medical treatment of menorrhagia -- NON-HORMONAL TREATMENTS -- HORMONAL TREATMENTS -- TREATMENT FAILURES -- Surgical treatment of menorrhagia -- HYSTERECTOMY -- OVARIES AND HYSTERECTOMY -- ENDOMETRIAL ABLATIVE TECHNIQUES -- COMPARISON OF ENDOMETRIAL ABLATIVE TECHNIQUES WITH HYSTERECTOMY -- Counselling in menorrhagia -- The ideal management of menorrhagia -- Fibroids -- MANAGEMENT -- Dysmenorrhoea -- PRIMARY DYSMENORRHOEA -- SECONDARY DYSMENORRHOEA -- TREATMENT -- ASSESSMENT -- References -- 7. Amenorrhoea -- Primary amenorrhoea -- Secondary amenorrhoea -- Examination and investigation of amenorrhoea -- Causes of amenorrhoea -- GENITAL TRACT ABNORMALITIES -- SYSTEMIC DISORDERS CAUSING SECONDARY AMENORRHOEA -- WEIGHT-RELATED AMENORRHOEA -- LEPTIN -- PSYCHOLOGICAL STRESS -- EXERCISE-RELATED AMENORRHOEA -- HYPOTHALAMIC CAUSES OF SECONDARY AMENORRHOEA -- PITUITARY CAUSES OF SECONDARY AMENORRHOEA -- IATROGENIC CAUSES OF AMENORRHOEA -- 8. Polycystic ovary syndrome -- Pathogenesis -- GENETICS OF POLYCYSTIC OVARY SYNDROME -- HETEROGENEITY OF POLYCYSTIC OVARY SYNDROME -- Management of polycystic ovary syndrome -- OBESITY -- MENSTRUAL IRREGULARITY -- INFERTILITY -- HYPERANDROGENISM AND HIRSUTISM -- References -- 9. Health consequences of polycystic ovary syndrome -- Insulin resistance -- Insulin resistance in polycystic ovary syndrome -- Other risk factors for ischaemic heart disease in women with polycystic ovary syndrome -- CENTRAL OBESITY -- IMPAIRED GLUCOSE TOLERANCE AND DIABETES -- HYPERTENSION -- DYSLIPIDAEMIA.

HYPERHOMOCYSTEINAEMIA -- Polycystic ovary syndrome in younger women -- Long-term follow-up in polycystic ovary syndrome -- Therapeutic options -- Polycystic ovary syndrome and cancer -- ENDOMETRIAL CANCER -- BREAST CANCER -- OVARIAN CANCER -- References -- 10. Anovulatory infertility andovulation induction -- Pituitary and hypothalamic causes of anovulation -- HYPOGONADOTROPHIC HYPOGONADISM -- WEIGHT-RELATED AMENORRHOEA -- Polycystic ovary syndrome (see also Chapter 8) -- LIFESTYLE AND WEIGHT LOSS IN POLYCYSTIC OVARY SYNDROME -- CLOMIFENE CITRATE THERAPY -- AROMATASE INHIBITORS -- GONADOTROPHIN THERAPY -- SURGICAL OVULATION INDUCTION -- THE ROLE OF METFORMIN AND OTHER INSULIN SENSITISERS -- IVF IN WOMEN WITH POLYCYSTIC OVARIES -- IN VITRO MATURATION OF OOCYTES -- Risks of ovulation induction -- Ovarian hyperstimulation syndrome -- MANAGEMENT OF OVARIAN HYPERSTIMULATION SYNDROME -- Summary -- References -- 11. Lactation and lactational amenorrhoea -- Initiation of lactation -- Maintenance of lactation and milk letdown -- Endocrine effects of lactation -- AMENORRHOEA -- HYPOESTROGENAEMIA -- SOCIAL EFFECTS -- Metabolic effects of lactation -- DIET -- WEIGHT CHANGE -- CONTROL OF LACTATION -- Lactation and contraception -- NATURAL CONTRACEPTION -- ARTIFICIAL CONTRACEPTION -- References -- 12. Hyperprolactinaemia -- MEDICAL MANAGEMENT -- SURGICAL MANAGEMENT -- EFFECT ON PREGNANCY -- Reference -- 13. Thyroid disease -- Scientific background -- Thyroid function -- CLINICAL EXAMINATION OF THE THYROID GLAND -- Classification and diagnosis (Table 13.2) -- SIMPLE NON-TOXIC GOITRE -- HYPOTHYROIDISM -- HYPERTHYROIDISM -- 14. Diabetes -- Definition -- Treatment and control -- Relevance to fertility -- Relevance to pregnancy -- Management of diabetes in pregnancy -- Managing the complications of diabetes inpregnancy.

Managing the complications of pregnancy in women with diabetes -- Type 2 diabetes, hyperinsulinaemia and insulin resistance -- References -- 15. Lipid metabolism and lipoprotein transport -- Transport of dietary fat -- HEPATIC LIPID METABOLISM -- ENDOGENOUS LIPID TRANSPORT -- HIGH-DENSITY LIPOPROTEINS AND REVERSE CHOLESTEROL TRANSPORT -- The effect of menopause on plasma lipoproteins -- References -- 16. Premature ovarian failure -- The control of ovarian ageing -- Definition and diagnosis -- Causation -- GENETIC CAUSES -- FAMILIAL FACTORS -- AUTOIMMUNE CAUSES -- Management -- OOCYTE DONATION -- CRYOPRESERVATION OF OVARIAN TISSUE -- References -- 17. Calcium metabolism and its disorders -- Calcium and bone homeostasis -- Parathyroid hormone and calcium -- Renal disease and calcium -- Osteoporosis and calcium -- References -- Appendix: Endocrine normal ranges -- Further reading -- Index.

Understanding endocrinology is central to understanding the key processes that affect normal reproductive function and when dealing with reproductive disorders. Primarily aimed at candidates preparing for the Part 2 MRCOG examination, this book provides a comprehensive background for all working in reproductive medicine.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.