Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants : Volume 2.

Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants -- Copyright -- Other Recent Reports -- BOARD ON ENVIRONMENTAL STUDIES AND TOXICOLOGY -- COMMITTEE ON TOXICOLOGY -- PREFACE -- Contents -- SPACECRAFT MAXIMUM ALLOWABLE CONCENTRATIONS FOR SELECTED AIRBORNE CONTAMINANTS -- INTRODUCTION -- SUMMARY OF REPORT ON GUIDELINES FOR DEVELOPING SMACS -- REVIEW OF SMAC REPORTS -- REFERENCES -- APPENDIX A GUIDELINES FOR DEVELOPING SPACECRAFT MAXIMUM ALLOWABLE CONCENTRATIONS FOR SPACE STATION CONTAMINANTS: EXECUTIVE… -- GUIDELINES FOR DEVELOPING SPACECRAFT MAXIMUM ALLOWABLE CONCENTRATIONS FOR SPACE STATION CONTAMINANTS: EXECUTIVE SUMMARY -- Environmental Control and Life-Support System -- Modification of Contaminant Toxicity by Environmental Factors -- Sources and Types of Data for Establishment of SMACs -- Chemical-Physical Characteristics of Toxicants -- In Vitro Toxicity Studies -- Animal Toxicity Studies -- Clinical and Epidemiological Observations -- Pharmacokinetics and Metabolism -- Biological Markers -- Risk Assessment (Development of Exposure Criteria) -- Issues in Making Recommendations for the Establishment of SMACs -- APPENDIX B REPORTS ON SPACECRAFT MAXIMUM ALLOWABLE CONCENTRATIONS FOR SELECTED AIRBORNE CONTAMINANTS -- B1 ACROLEIN -- Physical and Chemical Properties -- Occurrence and Use -- Pharmacokinetics and Metabolism -- Toxicity Summary -- Acute and Short-Term Toxicity -- Mucosal Irritation -- Respiratory Effects -- Miscellaneous Effects -- Subchronic and Chronic Toxicity -- Mucosal Irritation and Effects on the Respiratory System -- Miscellaneous Effects -- Carcinogenicity -- Genotoxicity -- Rationale for Acceptable Concentrations -- 1-h SMAC -- 24-h SMAC -- 7-d, 30-d, and 180-d SMACs -- The Establishment of SMAC Values -- References -- B2 BENZENE -- Physical and Chemical Properties -- Occurrence and Use.

Pharmacokinetics and Metabolism -- Absorption -- Distribution -- Excretion -- Metabolism -- Toxicity Summary -- Acute and Short-Term Toxicity -- Neurotoxicity -- Cardiac Sensitization -- Hematotoxicity and Immunotoxicity -- Genotoxicity -- Subchronic and Chronic Toxicity -- Neurotoxicity -- Hematotoxicity and Myelotoxicity -- Immunotoxicity -- Mutagenicity and Genotoxicity -- Carcinogenicity -- Reproductive Toxicity -- Developmental Toxicity -- Interaction with Other Chemicals -- Rationale for Acceptable Concentrations -- Species Extrapolation -- Benzene-Induced Toxicity -- Metabolite-Induced Toxicity -- Nervous System Effects -- Hematological Effects -- Immunological Effects -- Risk of Leukemia -- Summary of Toxic Effects -- Recommendations -- References -- B3 CARBON DIOXIDE -- Physical and Chemical Properties -- Occurrence and Use -- Pharmacokinetics and Metabolism -- Toxicity Summary -- Acute and Short-Term Toxicity -- Miscellaneous Signs and Symptoms -- Dyspnea -- Headaches -- Intercostal Pain -- Acid-Base Balance -- Electrolyte Levels -- Respiratory System -- Cardiovascular System -- Nervous System -- Kidneys -- Male Reproductive System -- Intestine and Spleen -- Subchronic and Chronic Toxicity -- Dyspnea and Intercostal Pain -- Headaches -- Nervous System -- Acid-Base Balance -- Electrolyte Levels -- Bones and Kidneys -- Respiratory System -- Cardiovascular System -- Structural Effects on Other Tissues -- Hematological Changes -- Carcinogenicity -- Epidemiological Data -- Genetic Toxicity -- Developmental Toxicity -- Interaction with Other Chemicals -- Rationale for Acceptable Concentrations -- Visual Impairments, Tremors, and CNS Depression -- Headaches -- Dyspnea and Intercostal Pain -- Hyperventilation -- Airway Resistance Increases -- Testes -- Establishment of SMACs -- References -- B4 2-ETHOXYETHANOL -- Physical and Chemical Properties.

Occurrence and Use -- Pharmacokinetics and Metabolism -- Absorption -- Metabolism and Excretion -- Toxicity Summary -- Acute and Short-Term Toxicity -- Subchronic and Chronic Toxicity -- Testicular Toxicity -- Hematological Toxicity -- Carcinogenicity -- Genotoxicity -- Developmental Toxicity -- Interaction with Other Chemicals -- Rationale for Acceptable Concentrations -- Mucosal Irritation -- Testicular Toxicity -- Hematological Toxicity -- Establishment of SMAC Values -- References -- B5 HYDRAZINE -- Physical and Chemical Properties -- Occurrence and Use -- Pharmacokinetics and Metabolism -- Absorption -- Distribution -- Excretion -- Metabolism -- Toxicity Summary -- Acute and Short-Term Toxicity -- Lethality -- Hepatotoxicity -- Subchronic and Chronic Toxicity -- Lethality -- Hepatotoxicity -- Carcinogenicity -- Genotoxicity -- Reproductive Toxicity -- Developmental Toxicity -- Interaction with Other Chemicals -- Rationale for Acceptable Concentrations -- Hepatotoxicity -- Focal-Liver-Cell Hyperplasia -- Carcinogenicity -- Lethality -- Spaceflight Effects -- Recommendations -- References -- B6 INDOLE -- Physical and Chemical Properties -- Occurrence and Use -- Pharmacokinetics and Metabolism -- Toxicity Summary -- Acute and Short-Term Toxicity -- Subchronic and Chronic Toxicity -- Carcinogenicity -- Rationale for Acceptable Concentrations -- Nausea -- Hematological Effects -- Mortality -- Leukemogenic Effects -- Normal Indole Uptake -- References -- B7 MERCURY -- Physical and Chemical Properties -- Occurrence and Use -- Pharmacokinetics and Metabolism -- Absorption -- Metabolism and Distribution -- Excretion -- Toxicity Summary -- Acute Toxicity -- Short-Term and Subchronic Toxicity -- Chronic Toxicity -- Genotoxicity and Carcinogenicity -- Reproductive and Developmental Toxicity -- Interactions with Other Chemicals.

Rationale for Acceptable Concentrations -- Respiratory System Toxicity -- Nephrotoxicity -- Neurotoxicity -- Recommendations -- References -- B8 METHYLENE CHLORIDE -- Physical and Chemical Properties -- Occurrence and Use -- Pharmacokinetics and Metabolism -- Absorption -- Distribution -- Metabolism -- Excretion -- Toxicity Summary -- Acute and Short-Term Toxicity -- CNS Effects -- Hepatic Effect -- Subchronic and Chronic Toxicity -- Carboxyhemoglobin Formation -- Non-neoplastic Effects on the Liver and Kidney -- Non-neoplastic Effects on the Respiratory System -- Neoplastic Effects -- Genotoxicity -- Developmental Toxicity -- Interaction with Other Chemicals -- Rationale for Acceptable Concentrations -- CNS Depression -- Liver Toxicity -- Carcinogenicity -- Establishment of SMAC Values -- References -- B9 METHYL ETHYL KETONE -- Physical and Chemical Properties -- Occurrence and Use -- Pharmacokinetics and Metabolism -- Absorption -- Metabolism and Excretion -- Toxicity Summary -- Acute and Short-Term Toxicity -- Mucosal Irritation -- Subchronic and Chronic Toxicity -- Neural Studies -- Mortality -- Hepatic Effects -- CNS Effects -- Carcinogenicity -- Genotoxicity -- Developmental Toxicity -- Interaction with Other Chemicals -- Rationale for Acceptable Concentrations -- Mucosal Irritation -- CNS Impairment -- Establishment of SMAC Values -- References -- B10 NITROMETHANE -- Physical and Chemical Properties -- Occurrence and Use -- Pharmacokinetics and Metabolism -- Toxicity Summary -- Acute and Short-Term Toxicity -- Lethality -- Miscellaneous Symptoms -- Hepatic Toxicity -- Subchronic and Chronic Toxicity -- Hepatic Toxicity -- Thyroid Toxicity -- Hematological Changes -- Pulmonary Toxicity -- Effects on Reproductive Function -- Carcinogenesis -- Genotoxicity -- Developmental Toxicity -- Interaction with Other Chemicals.

Rationale for Acceptable Concentrations -- Miscellaneous Symptoms -- Anemia -- Establishment of SMAC Values -- References -- B11 2-PROPANOL -- Physical and Chemical Properties -- Occurrence and Use -- Pharmacokinetics and Metabolism -- Absorption -- Distribution -- Excretion -- Metabolism -- Toxicity Summary -- Acute Toxicity -- Subchronic and Short-Term Toxicity -- Chronic Toxicity -- Reproductive and Developmental Toxicity -- Genotoxicity -- Carcinogenicity -- Interaction with Other Chemicals -- Rationale for Acceptable Standards -- CNS Depression -- Peripheral Nerve Damage -- Irritation -- Hepatotoxicity -- Recommendations for Additional Research -- References -- B12 TOLUENE -- Physical and Chemical Properties -- Occurrence and Use -- Pharmacokinetics and Metabolism -- Absorption -- Distribution -- Excretion -- Metabolism -- Toxicity Summary -- Acute and Short-Term Toxicity -- Lethality -- Irritation and CNS Effects -- Subchronic and Chronic Toxicity -- Histopathology, Clinical Chemistry, and Hematology -- Hepatotoxicity and Nephrotoxicity -- CNS Effects -- Lethality -- Carcinogenicity -- Genotoxicity -- Reproductive Toxicity -- Developmental Toxicity -- Interaction with Other Chemicals -- Rationale for Acceptable Concentrations -- Irritation -- Neurotoxicity -- Reproductive Toxicity -- Hepatotoxicity and Nephrotoxicity -- Lethality -- Spaceflight Effects -- Recommendations -- References.

Description based on publisher supplied metadata and other sources.

Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.