Acquired Brain Injury in the Fetus and Newborn.

Intro -- Contents -- Authors' Appointments -- Foreword -- Preface -- Acknowledgments -- 1 Brain Injury in the Fetus -- Introduction -- Overview of normal fetal brain development -- Normal function of the maternal placenta-fetalinterface -- Mechanisms of fetal brain injury -- Fetal errors of metabolism -- Conclusions -- 2 Imaging the Fetal Brain -- Introduction -- Imaging the fetal brain: ultrasound versus magnetic resonance imaging -- Imaging the fetal brain: the role of conventional magnetic resonance imaging -- Normal fetal brain development on conventional magnetic resonance imaging -- Fetal brain injury in the fetus on conventional magnetic resonance imaging -- Advanced magnetic resonance imaging techniques in the ex utero infant -- Acquired fetal brain injury and advanced in vivo fetal magnetic resonance imaging techniques -- Summary -- 3 Mechanisms of Acute and Chronic Brain Injury in the Preterm Infant -- Magnitude of the problem and spectrum of brain injury in preterm survivors -- Patholologic features of brain injury in preterm infants -- Pathophysiology of cerebral white matter injury -- Cellular-molecular mechanisms of acute white matter injury -- Cellular mechanisms of chronic white matter injury: myelination failure and the susceptibility of oligodendrocytes and axons -- Is acquired chronic brain injury in preterm infants necessarily static and irreparable? -- Clinical implications of potentially arrested white matter development -- 4 Clinical assessment of the Preterm Infant including Near-infrared spectroscopy, amplitude-integrated Electroencephalography, and Electroencephalography -- Near-infrared spectroscopy-monitored regional cerebral oxygen saturation -- Electroencephalography and amplitude-integrated EEG -- Conclusion -- 5 Imaging the Brain of the Preterm Infant -- Introduction.

Magentic resonance imaging of the brain in the normal preterm infant -- Magnetic resonance imaging of brain injury in the preterm infant -- Quantitative magnetic resonance studies of the developing brain in the preterm infant and association with neurodevelopmental outcome -- 6 Protecting the Brain of the Preterm Infant -- Introduction -- Intraventricular hemorrhage -- Posthemorrhagic ventricular dilation -- White matter injury -- Cerebellar injury -- Antenatal neuroprotective agents -- Developmental care and nutrition -- Emerging candidates for future neuroprotective investigations -- Conclusions -- 7 Seizures in the Preterm Infant -- Introduction -- Epidemiology -- Clinical features -- Differential diagnosis -- Investigations including imaging -- Treatment and management -- Short- and long-term outcomes -- Implications for future research -- 8 Outcomes After Brain Injury in the Preterm Infant -- Motor impairment -- Cognitive impairment -- Behavioral and psychiatric disorders -- Conclusion -- 9 Mechanisms of Brain Neurodegeneration in the Term Infant -- Introduction -- Types of cell death -- Molecular and cellular mechanisms of cell death in the immature brain -- Oxidative injury and inflammation -- Conclusion -- 10 Clinical Approach to Term Encephalopathy -- Introduction -- The basic concept of the neonatal neurologic examination -- 11 Imaging Term Infants with Suspected Hypoxic-Ischemic Encephalopathy -- Introduction: Why image the brain in a term newborn infant with encephalopathy? -- Pathophysiology of hypoxic-ischemic brain injury interm newborn infants -- Major patterns of brain injury -- Imaging features in term infants with hypoxic-ischemic encephalopathy -- Ultrasound imaging in term infants with suspected hypoxic-ischemic encephalopathy -- Computed tomography imaging in term infants with suspected hypoxic-ischemic encephalopathy.

Magnetic resonance imaging in term infants with suspected hypoxic-ischemic encephalopathy -- Imaging after the first week -- Other patterns of injury -- The value of visual scoring: predominant patterns of injury -- Quantitative magnetic resonance techniques -- 12 Protecting the Brain in Term Infants -- Excitotoxicity -- Cell death inhibitors -- Anti-inflammatory therapy -- Antioxidants -- Growth factors -- Stem cell therapy -- Hypothermia -- Combination therapy -- Conclusion -- 13 Seizures in the Term Newborn Infant -- Introduction -- Diagnosis of seizures: the relation to electroencephalopathy -- Diagnosis of seizures: the relation to amplitude integrated electroencephalography (aEEG) -- Diagnosis of seizures with access to aEEG and the'raw' EEG -- Pyridoxine-dependent epilepsy -- Benign familial neonatal seizures -- Treatment of neonatal seizures -- Prognosis -- Conclusions -- 14 Outcomes after Brain Injury in the Term Infant -- Introduction and definition -- Outcome after hypoxic-ischemic brain injury -- Implications for clinical follow-up assessment -- Case vignette -- 15 Neonatal Neurology in the Developing World -- Introduction -- Neonatal encephalopathy -- Sepsis and central nervous system infections in low- and mid-resource settings -- Biologic and environmental causes of neurodevelopmental impairment of children in low resource settings -- Summary -- 16 Perinatal Stroke -- Perinatal ischemic stroke -- Perinatal arterial ischemic stroke -- Symptomatic neonatal arterial ischemic stroke -- Presumed perinatal ischemic stroke -- Neonatal cerebral sinovenous thrombosis -- Perinatal hemorrhagic stroke -- 17 Brain Injury in Newborn Infants with Congenital Heart Disease -- Severe congenital heart disease - types, presentation,treatment, and risk of acquired brain injury.

Overview of developmental sequelae of children withcongenital heart defects -- 18 Metabolic Brain Injury in the Fetus and the Neonate -- Prenatal brain injury -- Postnatal brain injury in metabolic derangements -- 19 The Nutritionally Deprived Fetus and Newborn Infant -- Introduction -- Clinical antecedents leading to nutrient deprivationduring the fetal and neonatal period -- Effects of nutrient deprivation on the developing brain -- Summary and conclusions -- 20 Ethical Considerations in Fetal and Neonatal Neurology -- Part 1 -- Part 2 -- Part 3 -- Conclusion -- Index -- Color Plate.

Description based on publisher supplied metadata and other sources.

Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.