Human Population Genetics and Genomics.

Front Cover -- Human Population Genetics and Genomics -- Human Population Genetics and Genomics -- Copyright -- Dedication -- Contents -- Preface -- 1 - DEFINITION, SCOPE, AND PREMISES OF HUMAN POPULATION GENETICS -- THE BASIC PREMISES OF POPULATION GENETICS -- PREMISE 1: DNA CAN REPLICATE -- PREMISE 2: DNA CAN MUTATE AND RECOMBINE -- PREMISE 3: DNA AND THE ENVIRONMENT INTERACT TO PRODUCE PHENOTYPES -- NATURAL SELECTION AND THE INTEGRATION OF THE THREE PREMISES -- REFERENCES -- 2 - THE HUMAN GENOME -- COMPONENTS OF THE NUCLEAR GENOME -- GENES -- TRANSPOSABLE ELEMENTS -- REPETITIVE DNA -- CG ISLANDS -- CENTROMERES -- TELOMERES -- THE TRANSCRIPTOME -- THE EXOME, SPLICEOSOME, AND PROTEOME -- EPIGENOME -- THE MITOCHONDRIAL GENOME -- MUTATION AND RECOMBINATION IN THE HUMAN GENOMES -- MUTATION -- RECOMBINATION -- REFERENCES -- 3 - SYSTEMS OF MATING -- RANDOM MATING AND THE HARDY-WEINBERG LAW -- INBREEDING -- PEDIGREE INBREEDING -- SYSTEM OF MATING INBREEDING -- ASSORTATIVE MATING -- DISASSORTATIVE MATING -- COEXISTENCE OF MULTIPLE SYSTEMS OF MATING WITHIN A DEME -- REFERENCES -- 4 - GENETIC DRIFT -- THE FATE OF A NEWLY ARISEN MUTATION IN A LARGE POPULATION -- GENETIC DRIFT IN A FINITE POPULATION -- EFFECTIVE POPULATION SIZES -- GENETIC DRIFT AND LINKAGE DISEQUILIBRIUM -- GENETIC DRIFT AND NEUTRAL MUTATIONS -- REFERENCES -- 5 - A BACKWARD VIEW OF GENETIC DRIFT: COALESCENCE -- BASIC COALESCENT MODEL -- COALESCENCE WITH MUTATION -- HAPLOTYPE TREES -- HAPLOTYPE TREES, POPULATION TREES, AND SPECIES TREES -- COALESCENCE AND RECOMBINATION -- REFERENCES -- 6 - GENE FLOW AND SUBDIVIDED POPULATIONS -- A TWO-DEME MODEL OF GENE FLOW -- THE BALANCE OF GENE FLOW AND GENETIC DRIFT -- GENDER-BIASED GENE FLOW -- SYSTEM OF MATING AND GENE FLOW -- KIN-STRUCTURED MIGRATION -- ADMIXTURE -- ISOLATION BY DISTANCE AND RESISTANCE -- IDENTIFYING HUMAN SUBPOPULATIONS.

POPULATION SUBDIVISION, ISOLATION-BY-DISTANCE, AND EFFECTIVE POPULATION SIZES -- REFERENCES -- 7 - HUMAN POPULATION HISTORY OVER THE LAST TWO MILLION YEARS -- HAPLOTYPE TREES AS A WINDOW INTO THE PAST -- POPULATION TREES -- ANCIENT DNA-THE ORIGINS OF THE HUMAN GENE POOL -- ANCIENT DNA-THE LAST 25,000YEARS -- REFERENCES -- 8 - GENOTYPE AND PHENOTYPE -- FISHER'S QUANTITATIVE GENETIC MODEL -- CLASSICAL HUMAN QUANTITATIVE GENETIC ANALYSIS -- MEASURED GENOTYPE APPROACHES TO QUANTITATIVE GENETICS -- LINKAGE MAPPING -- RUNS OF HOMOZYGOSITY -- ADMIXTURE MAPPING -- GENOME-WIDE ASSOCIATION STUDIES -- CLASSICAL QUANTITATIVE GENETICS VERSUS MEASURED GENOTYPE APPROACHES -- REFERENCES -- 9 - NATURAL SELECTION -- A ONE-LOCUS, TWO-ALLELE MODEL OF NATURAL SELECTION -- SICKLE-CELL AND MALARIAL ADAPTATIONS: AN EXAMPLE OF THE MEASURED GENOTYPE APPROACH TO NATURAL SELECTION -- A QUANTITATIVE GENETIC, UNMEASURED GENOTYPE MODEL OF NATURAL SELECTION -- REFERENCES -- 10 - DETECTING SELECTION THROUGH ITS INTERACTIONS WITH OTHER EVOLUTIONARY FORCES -- INTERACTION OF SELECTION WITH MUTATION -- INTERACTIONS OF SELECTION WITH MUTATION AND GENETIC DRIFT -- INTERACTIONS OF SELECTION WITH MUTATION, GENETIC DRIFT, AND RECOMBINATION -- GENOMICS AND SELECTION ON QUANTITATIVE TRAITS -- DETECTING SELECTION WITH SAMPLES OVER TIME -- DETECTING SELECTION THROUGH INTERACTIONS WITH ADMIXTURE AND GENE FLOW -- DETECTING SELECTION WITH MULTIPLE STATISTICS -- REFERENCES -- 11 - UNITS AND TARGETS OF NATURAL SELECTION -- THE UNIT OF SELECTION -- TARGETS OF SELECTION -- GENOMES AND GAMETES -- SOMATIC CELLS -- MATING SUCCESS -- FERTILITY -- FAMILY SELECTION -- SOCIAL SELECTION -- MULTILOCUS EPISTASIS AND TARGETS OF SELECTION ABOVE THE LEVEL OF THE INDIVIDUAL -- REFERENCES -- 12 - HUMAN ADAPTATIONS TO TEMPORALLY AND SPATIALLY VARIABLE ENVIRONMENTS -- COARSE-GRAINED SPATIAL HETEROGENEITY.

COARSE-GRAINED TEMPORAL HETEROGENEITY -- FINE-GRAINED HETEROGENEITY -- REFERENCES -- 13 - SELECTION IN AGE-STRUCTURED POPULATIONS -- BASIC LIFE HISTORY THEORY AND FITNESS MEASURES -- GENETIC VARIATION IN LIFE HISTORY TRAITS -- THE EVOLUTION OF SENESCENCE -- DEMOGRAPHIC TRANSITIONS -- REFERENCES -- 14 - HUMAN POPULATION GENETICS/GENOMICS AND SOCIETY -- DO HUMAN RACES EXIST? -- MEDICINE -- HAS HUMAN EVOLUTION STOPPED? -- REFERENCES -- Index -- A -- B -- C -- D -- E -- F -- G -- H -- I -- K -- L -- M -- N -- O -- P -- Q -- R -- S -- T -- U -- V -- W -- X -- Y -- Back Cover.

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