Stem Cells : Cellular and Drug Therapies, Volume 1.

Intro -- STEM CELLS: CELLULAR AND DRUG THERAPIES (VOLUME 1) -- STEM CELLS:CELLULAR AND DRUG THERAPIES(VOLUME 1) -- Library of Congress Cataloging-in-Publication Data -- Contents -- Preface -- Introduction -- Acknowledgments -- References -- Chapter I: Adult Neurogenesis in Mammals -- Abstract -- 1. Introduction -- 2. Labeling Newly Generated Neuronal Cells in the Adult Brain -- 3. Modulation of Adult Neurogenesis -- 4. Function of Adult Neurogenesis -- 5. Contribution of Adult Neurogenesis to CNS Physiopathology -- 6. Neurogenesis in the Adult Human Brain: Particularities and Implications -- Conclusion -- Acknowledgments -- References -- Chapter II: Protocols for Studying Adult Neurogenesis: Insights and Recent Developments -- Abstract -- Executive Summary -- 1. Introduction -- 2. BrdU Labeling, Cell Proliferation, Migration, Birthdating, and Fate Determination -- 3. Controversies and Debates over the Use of BrdU for Studying Adult Neurogenesis -- 4. Alternative Strategies to Study Adult Neurogenesis -- 5. BrdU Labeling, Cell Kinetic and Cell Lineage Relative to Proliferative History -- Conclusion -- Acknowledgments -- References -- Chapter III: Adult Neural Stem Cells, Neurogenic Niches and Cellular Therapy -- Abstract -- Introduction -- Adult Neurogenesis and NSCs -- Neurogenic Niches -- Broader Potential of Adult Stem Cells -- Cellular Therapy -- Conclusion -- Acknowledgments -- References -- Chapter IV: The Therapeutic Potential of Adult Neural Stem Cells -- Abstract -- 1. Introduction -- 2. Adult Neurogenesis and Neural Stem Cells -- 3. Physiology of Newly Generated Neuronal Cells in the Adult Brain -- 4. Adult-Derived Neural Progenitor and Stem Cells -- 5. Cell-Based Therapies for the Treatment of CNS Diseases and Injuries -- Conclusion -- Author's Note -- Acknowledgments -- References -- Chapter V: Human Neural Progenitor and Stem Cells.

Abstract -- 1. Introduction -- 2. Chemistry -- 3. Biology and Action -- 4. Expert Opinion -- Acknowledgments -- References -- Chapter VI: Adult Neurogenesis Pharmacology in Neurological Diseases and Disorders -- Abstract -- Key Issues -- Introduction -- Neurogenesis in the Adult Brain -- Neurogenesis in Neurological Diseases and Disorders -- Neurogenesis and the Etiology of Neurological Diseases and Disorders -- Pharmacology of Adult Neurogenesis -- Discussion -- Expert Commentary and Five-Year View -- Financial and Competing Interests Disclosure -- Acknowledgments -- References -- Chapter VII: Characterization and Isolation of Synapses of Newly Generated Neuronal Cells of the Adult Hippocampus at Early Stages of Neurogenesis -- Abstract -- Introduction -- Materials and Methods -- Results -- Discussion -- Acknowledgments -- References -- Chapter VIII: Adult Neurogenesis and Neural Stem Cells as a Model for the Discovery and Development of Novel Drugs -- Abstract -- 1. Introduction -- 2. Adult Neurogenesis and Drugs to Treat Neurological Diseases and Disorders -- 3. Expert Opinion -- Declaration of Interest -- Acknowledgments -- Bibliography -- Chapter IX: Neurogenic Drugs and Compounds -- Abstract -- Introduction -- Recent Patents on Compounds and Drugs Modulating Neurogenesis in the Adult Brain -- Apigenin and Related Compounds -- Discussion -- Current and Future Developments -- Conflict of Interest -- References -- Chapter X: Magnetic Resonance Imaging for Monitoring Neurogenesis in the Adult Hippocampus -- Abstract -- 1. Introduction -- 2. Chemistry -- 3. Biology and Action -- 4. Expert Opinion -- Acknowledgments -- References -- Chapter XI: Transplantation of Cord Blood Stem Cells for Treating Hematologic Diseases and Strategies to Improve Engraftment -- Abstract -- Executive Summary -- Introduction -- HSCs and Cord Blood Stem Cells.

Selectins and the Homing of HSCs -- Transplantation of Cord Blood Stem Cells for the Treatment of Hematologic Diseases -- Strategies to Improve the Outcome of CB Transplantation for the Treatment of Hematologic Diseases -- Conclusion -- Future Perspectives -- Financial and Competing Interests Disclosure -- Acknowledgments -- References -- Chapter XII: Transplantation of Two Populations of Stem Cells to Improve Engraftment -- Abstract -- 1. Introduction -- 2. Methods -- 3. Biology and Action -- 4. Expert Opinion -- Acknowledgments -- References -- Chapter XIII: ADA-Transduced Hematopoietic Stem Cell Therapy for ADA-SCID -- Abstract -- Summary -- 1. Introduction -- 2. Synthesis and SAR -- 3. Preclinical Development -- 4. Metabolism and Pharmacokinetics -- 5. Toxicity -- 6. Clinical Development -- 7. Side Effects and Contraindications -- 8. Patent Summary -- 9. Current Opinion -- 10. Development History -- 11. Literature Classifications -- Acknowledgments -- References -- Chapter XIV: Adult Periodontal-Derived Neural Progenitor and Stem Cells -- Abstract -- 1. Introduction -- 2. Chemistry -- 3. Biology and Action -- 4. Expert Opinion -- Acknowledgments -- References -- Conclusion 1. Stem Cells from Non-Viable Versus Post-Mortem Tissues -- Acknowledgments -- References -- Conclusion 2. Ex Vivo Fucosylation to Improve the Engraftment Capability and Therapeutic Potential of Human Cord Blood Stem Cells -- Acknowledgments -- References -- Index.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.