Cancer and Stem Cells.

Intro -- CANCER AND STEM CELLS -- CANCER AND STEM CELLS -- Contents -- Preface -- Chapter 1 Cancer Stem Cells: A Definition -- Abstract -- Synonyms -- Abbreviations -- Definition -- Characteristics -- Identification -- Acknowledgements -- References -- Chapter 2 Mathematical Modeling of Stem Cells Related to Cancer -- Abstract -- Introduction -- Continuous Mathematical Models -- Continuous Models of Periodic Hematological Diseases -- A Continuous Model of Stem Cell and Cancer Stem Cell Proliferation, Differentiation and Maturation -- Interaction between Quiescent and Proliferating Stem Cells Described by a Continuous Mathematical Model -- A Continuous Mathematical Model for Nuclear Factor κB Complex Determinating the Proliferation of Adult Neural Stem Cells -- Discrete Mathematical Models -- A Discrete Cellular Automaton Model of Stem Cells and Tissue Homeostasis -- An Agent Based Model of Stem Cell and Non-Stem Cell Tissue Dynamics -- Conclusion -- Acknowledgments -- References -- Chapter 3 Where Do Cancer Stem Cells Come From? -- Introduction -- Cancer Stem Cell Hypothesis -- Adult Tissue Stem Cells -- Stem Cells within the Bone Marrow Have the Ability to Regenerate Multiple Tissue Types -- Similarity between the Somatic (Tissue) Stem Cells and Cancer Stem Cells -- The Niche and Stem Cell's Fate -- Cancer Stem Cells Originating from Bone Marrow -- Conclusion -- References -- Chapter 4 Mismatch Repair Deficiencies and Origin of Cancer Stem Cells -- Abstract -- 1. Introduction -- 1.1. DNA Repair Pathways -- 1.1.1. DNA Mismatch Repair (MMR) -- 1.1.1.1. Components of the DNA MMR System -- 1.1.1.1.0. Mismatch Recognition and Recruitment of Repair Enzymes -- 1.1.1.1.1. Excision of Mismatch and DNA Resynthesis -- 1.1.2. O6- Alkylguanine DNA Alkyl Transferase (AGT) Repair -- 1.1.3. Nucleotide Excision Repair (NER).

1.1.4. Base Excision Repair (BER) -- 1.1.5. Non-Homologous DNA End-Joining (NHEJ) Repair -- 1.1.6. Homologous Recombination (HR) Repair -- 1.2. MMR Deficiency and Stem Cell Defects -- 1.2.1. Cancer Stem Cells (CSCs) -- 1.3. Cancer Stem Cell Therapy -- 1.3.1. Elimination of Self-Renewal Capacity -- 1.3.2. Induction of Differentiation -- 1.3.3. Inhibition of Drug Transporters -- 1.3.4. Gain of MMR Function -- 1.4. Conclusion -- References -- Chapter 5 Cancer Stem Cells in Hematological Malignancies -- Abstract -- Abbreviations -- 1. Introduction -- 2. CSCs in Chronic and Acute Leukemias -- 2.1. LSCs in Chronic Myelogeneous Leukemia (CML) -- 2.2. LSCs in Acute Myelogeneous Leukemia (AML) -- 2.3. Lymphoid LSCs -- 3. Cancer Stem Cell Concepts and Questions: Lessons from Leukemia -- 3.1. 'Cell of Origin' and the CSC -- 3.2. CSCs: Are They Rare? -- 4. Therapeutic Implications of Drug Resistant CSCs -- 5. Eradication of LSCs -- Conclusion -- References -- Chapter 6 Stem Cells in Solid Tumors -- Abstract -- Introduction -- Cancer Stem Cells in Human Solid Tumors -- Stem Cells in Mouse Models of Cancer -- Linking Molecular Stem Cell Pathways to Cancer -- Stem Cell Niche and Cancer -- Anticancer Therapeutics Based on the Cancer Stem Cell Model -- Conclusion -- Acknowledgements -- References -- Chapter 7 Cancer Stem Cells and Metastasis -- Abstract -- Introduction -- Poor Prognosis, Primary Tumors and pCSCs -- pCSC Origins and Metastasis -- Metastatic Cancer Stem Cells -- The (PRE)-Metastatic Niche and mCSCs -- Metastasis, CSCs and Chemotherapy -- Self-Renewal and Differentiation -- Metastasis Niche -- Reactivation -- CSC Clearance -- Conclusion -- References -- Chapter 8 Exercise, Stem Cells and Cancer -- Introduction -- Exercise and Stem Cells -- Exercise and Endothelial Progenitor Cells -- Exercise and Hematopoietic Stem Cells (HSCs).

Potential Mechanisms for the Mobilization of EPCs and HSCs -- Exercise and Myogenic Satellite Cells -- Exercise and Cancer -- Physical Activity during Cancer Pre-Diagnosis Period -- Physical Activity during Cancer Post-Diagnosis -- Physical Activity, Cancer and Murine Tumour Models -- Perspectives -- References -- Chapter 9 Human Adult Stem Cells as Targets for Cancer Stem Cells: Evolution -- Oct-4 Gene and Cell-to-Cell Communication -- Abstract -- Introduction: The Complexicity of a Complicated Disease -- The Interaction of Biological and Cultural Evolutionary Factors -- No One Appendage Describes an Elephant, Nor Does Only One Thing Cause Cancer! -- From Single Cell Organisms to Multi-Cellular Organisms: Cancer as the "Faustian Bargain" We Paid for Our Survival -- Stem Cells, Cell Communication and Development -- The Stem Cell or De-Differentiation Hypothesis of Carcinogenesis -- Stem Cells, the Multi-Step, Multi-Mechanism Carcinogenic Process of Initiation, Promotion and Progression -- The Mutation or Epigenetic Theories of Carcinogenesis -- Oncogenes, Tumor Suppressor Genes, and Cancer Cells -- Adult Stem Cells as the Targets for Carcinogenic Initiation -- Cancer Stem Cells: A Re-Discovery of an Old Idea -- Dietary Modulation of Normal and Cancer Stem Cell Pools: A View of How Diet, Systems View of Cell Biology, and the Risk to Cancer Interact -- Why Dogs and Cows Caused Human Prostate and Breast Cancers: The Interaction of Biological and Cultural Evolution, Diet, Adult Stem Cells and Cancer -- Conclusion -- References -- Chapter 10 Targeting Cancer Stem Cells -- Abstract -- Let's Talk about Cancer Stem Cells -- What Are the Best Strategies to Target Cancer Stem Cells? -- Conclusions -- Acknowledgements -- References -- Index -- Blank Page.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.