Amphetamines : Neurobiological Mechanisms, Pharmacology and Effects.

Intro -- AMPHETAMINES -- AMPHETAMINES -- Contents -- Preface -- Psychpharmacology and Neurotoxicology of Methamphetamine and 3,4-Methylenedioxymeth- amphetamine -- Abstract -- Introduction -- 1. Molecular Mechanisms of Action -- 2. Acute Effects -- 2.1. Acute Neurochemical Effects -- 2.2. Acute Physiological and Autonomic Effects -- 2.3. Behavioral Effects -- 3. Effects of Chronic Exposure in Animals -- 3.1. Changes in Transporters, Receptors, and Enzymes with Chronic Exposure -- 3.2. Neurotoxicity -- 4. Behavioral Effects of Chronic Use in Humans -- 4.1. Psychosis -- 4.2. Cognitive Deficits -- Conclusion -- References -- Methamphetamine and 3,4-Methylene-Dioxymethamphetamine: From Classical to New Molecular Mechanisms of Neurotoxicity -- Abstract -- Introduction -- Involvement of DA, PKC and Neuronal NOS in METH- and MDMA-Induced ROS Production -- Involvement of nACHR in METH and MDMA-Induced ROS Production -- In Vivo Neuroprotection by MLA against METH- and MDMA-Induced Dopaminergic Neurotoxicity -- Memantine Protects from MDMA-Induced CNS Injury -- Nicotinic Receptors and the Cognitive Impairment Induced by MDMA and METH -- Amphetamine Derivates Directly Interact with nACHR -- METH and MDMA Increase the Density of Nicotinic Receptors -- Role of Protein Synthesis, Cyclophilin A, Protein Kinase and Receptor Trafficking -- Intracellular Ca2+ Increase Induced by MDMA in PC12 Cells -- Mechanisms Involved in MDMA-Induced Ca2+ Increase -- Effects of MDMA on Basal Ca2+ Levels -- Calpain/Caspase-3 Activation Induced by MDMA -- Functional up-Regulation of nACHR by Amphetamine Derivatives -- Conclusion -- References -- Enhance or Reduce the Rewarding Effects: Interpretation of Drug Dependence by Amphetamine Sensitization -- Abstract -- 1. Introduction -- 2. The Habituation of Associative Learning -- 3. The Allostatic Hypothesis.

4. The Incentive-Sensitization Theory -- 5. The Adjustment of Dopamine Function in Amphetamine Dependence -- 5.1. The Role of Nucleus Accumbens -- 5.2. The Regulation of Amphetamine Sensitization by Glutamate -- 5.3. Phasic and Tonic Dopamine Release -- 6. Amphetamine Psychosis and Amphetamine Dependence -- 7. Conclusion -- References -- Amphetamine Effects on Allergic Lung Inflammation -- Abstract -- Introduction -- Part 1. Acute AMPH Treatment -- Part 2. Chronic AMPH Treatment -- Conclusion -- Perspectives -- Acknowledgments -- References -- Withdrawal from Amphetamine as an Animal Model of Schizophrenia -- Abstract -- Introduction -- Dopamine and the Endogenous Sensitization Theory of Schizophrenia -- Effects of Amphetamine Withdrawal on Latent Inhibition -- Effects of Amphetamine Withdrawal on Pre-Pulse Inhibition -- Cognitive Effects of Amphetamine Withdrawal -- The Underlying Mechanism of Withdrawal from Amphetamine -- Conclusion -- Acknowledgments -- References -- Regulating the Expression Patterns of Bizarre Behavior: A Therapeutic Option for Amphetamine-Type Drug-Induced Stereotypy? -- Abstract -- Introduction -- The Relationship between the Doses of Amphetamines and the Features (Pattern and Frequency) of the Stereotypical Behavior Presented in Animal Models -- The Monoaminergic Systems Involved in the Expression of Stereotypy -- Dopaminergic System -- 5-HTergic System -- Noradrenergic System -- The Potential of Non-monoaminergic Systems as Therapeutic Targets for AMPH-induced Stereotypy -- Specific Neurotransmission Involved in the Alteration of the AMPH-induced Expression Patterns of Stereotypy in Rodents -- Histamine H1 Receptor-mediated Regulation -- Sigma1 Receptor-mediated Regulation -- Regulating the Expression Patterns of AMPHs-induced Stereotypy: A Therapeutic Target for AMPHs Abuse? -- Acknowledgments -- References.

The Importance of Contextual Control over Amphetamine Dependence: Evidence from an Animal Model of Addiction -- Abstract -- 1. Introduction -- 2. Methamphetamine: Pharmacological and General Aspects -- 3. Behavioral Sensitization as an Animal Model of Addiction to Amphetamines -- 4. Role of Environmental Conditioning in Amphetamine-Induced Locomotor Activity Sensitization -- 5. Role of Social Context 5. Role of Social Context Locomotor Activity Sensitization -- 6. Role of Environmental Affective Valence in Amphetamine-Induced Locomotor Activity Sensitization -- 7. Role of Environmental Novelty in Amphetamine-Induced Locomotor Activity Sensitization -- Conclusion -- Acknowledgement -- References -- Index.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.