Advancements in Cancer Research.

Intro -- ADVANCEMENTS IN CANCER RESEARCH -- ADVANCEMENTS IN CANCER RESEARCH -- Library of Congress Cataloging-in-Publication Data -- CONTENTS -- PREFACE -- Chapter 1: AN OUTLOOK ON UTERINE NEOPLASMS: FROM DNA DAMAGING TO ENDOMETRIAL AND CERVICAL CANCER DEVELOPMENT AND MINIMALLY INVASIVE MANAGEMENT -- ABSTRACT -- INTRODUCTION -- ENDOMETRIAL CANCER AND HORMONAL CARCINOGENESIS -- ENDOMETRIAL HYPERPLASIA: A POSSIBLE PRE-CANCER -- Minimally Invasive Surgical Treatment of Endometrial Hyperplasia -- Minimally Invasive Surgical Treatment of Endometrial Cancer -- Cervical Tumors and HPV Correlation -- Genomic Detection of HPV by DNA Chips: A New Frontier -- MECHANISMS OF PATHOGENESIS OF CERVICAL TUMORS BY HPV -- Minimally Invasive Surgical Treatment of Benign Cervical Pathologies -- Cervical Cancer and Endoscopic Surgical Treatments -- Cervical Cancer and Vaccine -- CONCLUSIONS -- REFERENCES -- Chapter 2: BREAST CANCER KNOWLEDGE, RISK FACTORS AND SCREENING AMONG ADULT SAUDI WOMEN AT PRIMARY HEALTH CARE SETTING -- ABSTRACT -- INTRODUCTION -- SETTING AND DESIGN -- Participants and Method -- Method of Data Collection -- Data Management and Analysis -- Ethical Considerations -- RESULTS -- Knowledge towards Breast Cancer Risk Factors -- Clinical Breast Examination and Mammography -- Perceived Barriers Towards CBE -- Risk Factors for Breast Cancer -- Correlates of Knowledge -- DISCUSSION -- CONCLUSION -- RECOMMENDATIONS -- REFERENCES -- Chapter 3: DENDRITIC CELL IMMUNOTHERAPY FOR THE TREATMENT OF MALIGNANT MELANOMA -- ABSTRACT -- INTRODUCTION -- TECHNIQUES FOR PREPARING DENDRITIC CELL VACCINES -- RESULTS OF DC VACCINATIONSTUDIES IN MELANOMA -- PERSPECTIVES -- DISCLAIMER -- REFERENCES -- Chapter 4: MATRIX METALLOPROTEINASES (MMP-1, MMP-2, MMP-9) AND THEIR ENDOGENOUS INHIBITORS (TIMP-1 AND TIMP-2) IN SQUAMOUS CELL CERVICAL CARCINOMAS -- ABSTRACT -- INTRODUCTION.

MATERIALS AND METHODS -- Clinical Material -- DNA and RNA Extraction -- RT-PCR -- Gel Electrophoresis in Agarose and Processing of Results -- Collagenolytic Activity -- Zymography -- Immunohystochemistry -- RESULTS -- mRNA Expression of MMPs and TIMPs -- Collagenolytic Activity -- Zymography of Gelatinases A and B -- Immunohistochemical Studies -- CONCLUSION -- REFERENCES -- Chapter 5: OVER EXPRESSION OF PERIPHERAL BENZODIAZEPINE RECEPTORS IN BREAST CANCER DEVELOPMENT -- ABSTRACT -- INCIDENCE OF BREAST CANCER -- WHAT IS PBR? -- ROLE OF PBR IN CANCER -- IMPACT OF DIET ON PBR MEDIATED CANCER -- THERAPEUTIC APPROACH TO PREVENT BY TARGETING PBR -- ACKNOWLEDGMENT -- REFERENCES -- Chapter 6: ROLE OF EFFECTORS ON HYPOXIA DUE TO NITRIC OXIDE PRODUCTION IN HUMAN ALVEOLAR EPITHELIAL CELLS AND OXYGEN DEPLETION IN HUMAN HEPATOCYTES: PART II. A TOOL OF NITROIMIDAZOLE CYTOTOXICITY ASESSMENT -- ABSTRACT -- INTRODUCTION -- MATERIALS AND METHODS -- Human Hepatocytes and Kupffer Cell Preparation -- Enzyme Preparations -- Adenylate Cyclase Assay -- Isolated Hepatocyte Cultures and Effectors -- Isolated Kupffer Cell Cultures and Effectors -- RESULTS -- DISCUSSION -- REFERENCES -- SHORT BIOGRAPHICAL SKETCH -- Chapter 7: PATHOGENESIS OF KAPOSI SARCOMA ASSOCIATED WITH HUMAN HERPESVIRUS-8 INFECTION -- ABSTRACT -- INTRODUCTION -- FOUR TYPES OF KAPOSI SARCOMA -- Classic Kaposi Sarcoma -- Endemic Kaposi Sarcoma -- Post Transplantation Kaposi Sarcoma -- Epidemic Kaposi Sarcoma -- HISTOPATHOLOGY OF KAPOSI SARCOMA AND SPINDLE CELL ORIGIN -- HHV-8/KSHV -- Viral Cyclin -- CYTOKINE SECRETION AND INFLAMMATORY REACTION -- HHV-8 Induced Angiogenesis -- ANGIOGENESIS AND FIBROBLAST PROLIFERATION -- REFERENCES -- Chapter 8: COMPLEMENTARY AND ALTERNATIVE MEDICINE APPROACHES IN THE TREATMENT OF CANCER -- ABSTRACT -- INTRODUCTION -- COMPLEMENTARY AND ALTERNATIVE METHODS FOR CANCER MANAGEMENT.

1. Essiac Herbal Formula -- 2. Cartilage -- 3. Gerson Therapy -- 4. Specific Botanicals -- 5. Dietary Phytochemicals -- CONCLUSION -- REFERENCES -- Chapter 9: INTRINSIC AND EXTRINSIC MECHANISMS OF DRUG RESISTANCE -- ABSTRACT -- INTRODUCTION -- MULTIDRUG RESISTANCE PHENOTYPE -- TARGETED MOLECULAR THERAPIES AND CHALLENGES -- DNA DAMAGE TOLERANCE PATHWAY -- MICROENVIRONMENTAL INFLUENCES ON DRUG SENSITIVITY -- Extracellular Matrix (ECM) -- Soluble Factors -- MODELS FOR STUDYING DRUG RESISTANCE -- CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 10: BEE VENOM AND MELITTIN ARE CYTOTOXIC AGAINST DIFFERENT TYPES OF TUMOR ANDNON-TUMOR CELL LINES IN VITRO -- ABSTRACT -- ABBREVIATIONS -- INTRODUCTION -- MATERIALS AND METHODS -- Agents -- Cell Lines -- Cytotoxicity MTT Assay -- Morphological Changes and the Type of the Cell Death -- RESULTS -- DISCUSSION -- ACKNOWLEDGMENT -- REFERENCES -- Chapter 11: ADJUVANT CHEMOTHERAPY FOR RESECTED COLORECTAL CANCER -- ABSTRACT -- INTRODUCTION -- Adjuvant Chemotherapy - A Balance of Risks and Benefits -- The Evolution of Systemic Adjuvant Chemotherapy in Stage III Disease -- FLUOROURACIL MONOTHERAPY -- Intravenous Bolus 5-Fluorouracil -- The Role of 5-FU Adjuncts -- Continuous Infusion 5-FU in Stage III Disease -- THE DEVELOPMENT OF ADJUVANTCOMBINATION CHEMOTHERAPY -- Oxaliplatin -- Irinotecan -- Stage II Disease -- MODALITIES OF ADJUVANT CHEMOTHERAPY OTHER THANSYSTEMIC INTRAVENOUS TREATMENT -- Oral Fluoropyrimidines -- Anatomically Targeted Chemotherapy -- COX-2 Inhibitors -- OTHER CONSIDERATIONS IN ADJUVANT CHEMOTHERAPY -- Elderly Patients -- Adjuvant Chemotherapy Following NeoadjuvantTherapy in Rectal Carcinoma -- Timing after Surgery -- Duration of Treatment -- Post-Treatment Surveillance -- FUTURE DIRECTIONS IN ADJUVANTCHEMOTHERAPY FOR COLORECTAL CARCINOMA.

Accelerating the Introduction of New Adjuvant Regimens -Disease Free Survival as a Proxy for Overall Survival -- Tools for Risk Stratification Other Than Pathological Stage and Grade -- Microsatellite Instability -- Reverse-Transcriptase Polymerase Chain Reaction (RT-PCR) -- Gene Expression Profiling -- Monoclonal Antibodies -- Cetuximab -- Bevacizumab -- Edrecolomab -- CONCLUSIONS -- REFERENCES -- Chapter 12: HIGH-DOSE-RATE INTERSTITIAL BRACHYTHERAPY IN THE MANAGEMENT OF PRIMARY AND RECURRENT GYNAECOLOGIC MALIGNANCIES: CLINICAL EXPERIENCE AND REVIEW OF THE LITERATURE -- ABSTRACT -- INTRODUCTION -- Materials and Methods -- Results -- Response to Treatment and Tumor Control -- Discussion -- Dose-Volume Parameters for the Oars -- CONCLUSION -- REFERENCES -- Chapter 13: AN INTRODUCTORY IN METABOLISM OF XENOBIOTICS -- INTRODUCTION -- CINNAMIC ACID AND HIPPURIC ACID -- A. CYTOCHROME P450-DEPENDENT BIOTRANSFORMATIONS -- I. Hydroxylation -- II. Other cytp450s-Mediated Biotransformations Include -- B. OTHER PHASE I BIOTRANSFORMATIONS -- BIOACTIVATION (FATE OR BIOLOGICAL HAZARDS) OFXENOBIOTIC METABOLISM -- Detoxificating vs. Bioactivating Function of Phase I Reactions -- OXIDATIVE STRESS AND XENOBIOTICS -- INDEX.

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