DNA Identification : Lessons Learned From 9-11.

Intro -- DNA Identification: Lessons Learned from 9-11 -- Contents -- Preface -- Message from the Director -- Acknowledgments -- Kinship and Data Analysis Panel -- Introduction -- Is the Laboratory Prepared to Handle a Mass Fatality? -- How DNA Is Used to Make Identifications -- Before the Incident -- Major Decisions -- How Important is DNA to the Identification Effort? -- Will Every Person or Every Fragment Be Identified? -- What Is the Minimum Fragment Size that Will Be Identified? -- How Difficult Will It Be to Identify Everyone? -- How Long Will the Recovery Effort Last? -- Assuming Funding, Can the Laboratory Do the Work? -- What Is the Funding Source? -- Managing Expectations -- Project Management -- Project Functions -- Project Structure: Centralized vs. Decentralized -- Special Requests -- Project Manager -- External Relationships -- Human Resources -- Media Relations -- Family Coordination and Liaison -- The Family-Laboratory Relationship -- Collecting Reference Samples -- Family-Laboratory Communications -- Information Technology -- Sample Accessioning/LIMS Requirements -- Quality Control Software -- Matching and Statistics Software -- Sharing Information -- Infrastructure -- Conclusion -- Sample Tracking and Management -- Sample Analysis -- Sample Collection -- Sample Storage -- Short Tandem Repeat (STR) DNA Amplification and Analysis -- Alternative Testing Methods -- Statistical and Other Issues -- Statistical Threshold -- Open versus Closed Incidents -- Non-DNA Data ("Metadata") -- Fragmented Remains -- Kinship Analysis -- Administrative and Technical Reviews -- Procedurement and Vendor Management -- Ordering Supplies and Equipment -- Outsourcing Sample Testing -- Consultants -- Vendor Management -- Quality Control -- Intentional Redundancy -- Multiple Test and Software Systems.

Appendix A. Recommendations of the Kinship and Data Analysis Panel (KADAP) to the Office of the Chief Medical Examiner of New York City During the World Trade Center DNA Identification Effort -- 1st KADAP (October 18-20, 2001) -- 2nd KADAP (November 20, 2001) -- 3rd KADAP (February 21-22, 2002) -- 4th KADAP (April 24-25, 2002) -- 5th KADAP (July 15-16, 2002) -- 6th KADAP (September 9-10, 2002) -- SNP Recommendation (December, 2002) -- 7th KADAP (January 21-22, 2003) -- 8th KADAP (July 7-8, 2003) -- Appendix B. Sample Personal Items Submission Form -- Appendix C. Sample Family and/or Donor Reference Collection Form -- Appendix D. Sample Family Tree Form -- Appendix E. Guidelines for Family and/or Donor Reference Collection Kit Components and Oral Swab Collection Instructions -- Oral Swab Collection Instructions -- Appendix F. Issues to Consider when Outsourcing Reference Samples -- Tasks and Requirements -- Deliverables and Delivery Schedule -- Suspension and Termination -- Equipment and Materials -- Appendix G. Identifying Victims Using DNA: A Guide for Families -- Appendix H. Sample Analysis: An Overview -- Sample Receipt Accessioning and Storage -- DNA Extraction -- Short Tandem Repeat (STR) Analysis -- Alternative Testing Methods -- Making the Identification -- Appendix I. Additional References on Statistical Issues in DNA Identification -- Untitled.

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