Chemokines : Types, Functions, and Structural Characteristics.

Intro -- CHEMOKINES: TYPES, FUNCTIONS AND STRUCTURAL CHARACTERISTICS -- CHEMOKINES: TYPES, FUNCTIONS AND STRUCTURAL CHARACTERISTICS -- Contents -- Preface -- Chapter 1 Mechanisms and Development of Chemokine Network Targeting Agents for the Treatment of Allergic, Autoimmune and Inflammatory Diseases and Cancers -- Abstract -- Introduction -- The Question of Redundancy -- Selection of Chemokine Targets -- Chemokine Receptor Antagonism -- Current Status -- Biology of GAGs in Chemokine Biology and Leukocyte Trafficking -- Glycosaminoglycan Structure, Function and Diversity -- Specificity in Chemokine-GAG Interactions and GAG-Induced Oligomerization -- Chemokine Oligomerization Controls Cell Surface Presentation -- Non-GAG Binding and Improved GAG Binding Chemokine Mutants -- Double Negative Knockout Chemokine Mutants with Improved GAG Affinity and Ablated Chemokine Receptor Binding Potential -- Other Novel Therapeutic Approaches -- Broad-Spectrum Chemokine Inhibitors (BCSIs) -- Spiegelmers -- Bindarit -- Chemokine-Targeted Cell Depleting Agents -- Chemokines and Gene Therapy -- Gene Therapy Vectors and Delivery -- Direct Gene Delivery in vivo -- Immune Effector Cell Recruitment -- Regulation of Angiogenesis -- Inhibition of Endogenous Chemokine Ligands -- Stem Cell Therapy -- RNA Interference -- Background -- RNAi Developmental Hurdles -- RNAi Studies in Cancer and Metastasis -- RNAi Studies in Viral Infection -- RNAi Studies in Inflammatory Diseases -- Conclusion -- Acknowledgments -- References -- Chapter 2 How Chemokines Implicate in T Lymphocyte Biology -- Abstract -- Introduction -- The Role of Chemokines and Chemokine Receptors on Gamma Delta Development in the Thymus -- Chemokine Guidance of Tissue-Specific Homing and Recirculation of T Lymphocytes -- Migration of T Lymphocytes into Tissue during Inflammation.

Chemokine Receptors as Markers of T Lymphocyte Phenotype -- Production of Chemokines by T Lymphocytes in Inflammation &amp -- Infection -- Concluding Remarks -- Footnote -- References -- Chapter 3 Chemokines in Teleost Fish Species -- Abstract -- Introduction -- Zebrafish Chemokines -- Rainbow Trout Chemokines -- Catfish Chemokines -- Chemokines in Other Fish Species -- Chemokine Receptors -- Conclusion -- Acknowledgments -- References -- Chapter 4 Gene Regulation and Expression of Chemokines in Response to Bacterial Enterotoxins -- Abstract -- Introduction -- B. Fragilis Enterotoxin Stimulation Up-Regulates Cxc Chemokines in Intestinal Epithelial Cells -- C. Difficile Enterotoxin (Toxin A) Up-Regulates CXC and CC Chemokines in Intestinal Epithelial Cells -- NF- B Activation Pathway in Intestinal Epithelial cells is a Major Regulator of Chemokine Gene Expression in Intestinal Epithelial cells Stimulated With B. Fragilis Enterotoxin and C. Difficile Toxin A -- Hsp90 and IKK Complex is Involved in the Gene Regulation of Chemokines in Response to Enterotoxin Stimulation -- Mitogen-Activated Protein Kinase (MAPK) and Transcription Factor AP-1 (Activator Protein-1) are Involved in Chemokine Expression in Intestinal Epithelial cells Stimulated with Bacterial Enterotoxin -- Inhibition of NF- B Signals Decreases Neutrophil Transepithelial Migration in T84 cells Stimulated with B. Fragilis Enterotoxin -- Conclusion -- Acknowledgments -- References -- Chapter 5 Regulation of Host Chemokine Response by the Pathogenic Type III Secretion System -- Abstract -- Introduction -- Salmonella Typhimurium: Effector-Driven Manipulation of the Host -- Yersinia Pestis: TTSS-Mediated Virulence Effectors in Plague -- Burkholderia Pseudomallei: A Public Health Threat in Southeast Asia -- Conclusion -- Acknowledgment -- References.

Chapter 6 Chemokines: Types, Functions, and Structural Characteristics -- Abstract -- Introduction -- Chemokine Structure -- Chemokine Family -- Chemokine Receptors -- Chemokines: When They Come on the Scene? -- Functions of Chemokines -- Inflammation -- Lymphocyt Trafficking -- Th1/Th2 Immune Responses -- Wound Healing and Angiogenesis -- Hemostasis and Thrombosis -- The Role of the Chemokines in Different Diseases -- Inflammatory Diseases -- Inflammatory Bowel Disease -- Autoimmune Diseases -- Allergic Diseases -- Atherosclerosis -- Infectious Diseases -- Protozoal Infections -- Angiogenesis, Tumor Growth and Metastasis -- Organ Transplantation -- Liver Diseases -- Renal Diseases -- Endocrine Diseases -- Neurologic Diseases -- Skin Diseases -- Other Diseases -- Desensitization to the Chemokines -- Therapeutic Approaches Targeting Chemokines -- References -- Chapter 7 Role of CXC-Chemokines CXC-Receptors in Metastasis of Colorectal Cancer -- Summary -- Background -- Material and Methods -- MIP-2 and Tumor Growth -- SDF-1 and Tumor Growth -- Conclusion -- Directed Tumor Metastasis -- Macrophage Inflammatory Protein (MIP)-2 -- MIP-2 and Colorectal Liver Metastasis -- Studies on MIP-2 in a Model of Extrahepatic Colorectal Metastasis -- Liver Resection and Tumor Cell Migration -- The Role of Mip-2 in Liver Resection-Induced Acceleration of Tumor Growth -- MIP-2 and Liver Resection-Associated Extrahepatic Tumor Growth -- Stromal Cell-Derived Factor (SDF)-1 and Colorectal Cancer -- Targeting Chemotactic Signaling in Cancer - A New Perspective? -- References -- Chapter 8 Regulated Secretion of Chemokines from Endothelial Cells -- Abstract -- Regulated Secretion -- Chemokines in Leukocyte Extravasation -- Regulated Secretion of Chemokines from ECs -- Compartments of Regulated Secretion in ECs -- The Weibel-Palade Body.

The Type 2 Endothelial Secretory Granule -- Agonists and Signalling Pathways Involved in Secretory Granule Exocytosis -- Differential Sorting and Release of Chemokines -- Mechanisms of Chemokine Sorting to Regulated Secretory Compartments -- Mediators that Enable Differential Release -- The function of Differential Granule Sorting and Release -- Conclusion -- References -- Index.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.