DNA Replication and Mutation.

Intro -- DNA REPLICATIONAND MUTATION -- DNA AND RNA: PROPERTIESAND MODIFICATIONS, FUNCTIONSAND INTERACTIONS, RECOMBINATIONAND APPLICATIONS -- Library of Congress Cataloging-in-Publication Data -- Contents -- Preface -- Connections between BLMand the Fanconi AnemiaPathway in the Repair ofReplication Fork Damage -- Abstract -- RecQ DNA Helicases -- BLM and Regulationof Homologous Replication -- Connections between FANCM of the FanconiAnemia Pathway and BLM -- Connections between FANCJ of the FAPathway and BLM -- The Structure-Specific EndonucleaseSLX4-SLX1 and Its Relationshipto BLM and the FA Pathway -- Conclusion -- Acknowledgments -- References -- Mutagenic Potentialof Methacrylates Usedin Restorative Dentistry -- Abstract -- Introduction -- Materials and Methods -- Chemicals -- Cells -- Cell Treatment -- Cell Viability -- Plasmid Relaxation Assay -- Comet Assay -- Oxidative Damage to DNA -- DNA Double-Strand Breaks Assays -- Apoptosis -- Cell Cycle -- Data Analysis -- Results -- Cell Viability -- DNA Damage In Vitro -- DNA Damage in Human Gingival Fibroblasts -- DNA Double-Strand Breaks -- DNA Repair -- Oxidative Modifications to the DNA Bases -- Apoptosis -- Cell Cycle -- Discussion -- Acknowledgments -- Conflict of Interest Statement -- References -- DNA Mutation of theProgranulin (GRN) Gene inFamilial Frontotemporal LobarDegeneration (FTLD): A Studyof the Pathology of Nine Cases -- Abstract -- Introduction -- Heterogeneity of FTLD-TDP -- DNA Mutations -- Objectives -- Materials and Methods -- Cases -- Histological Methods -- Morphometric Measurements -- Measurement of Density of Inclusions -- Spatial Patterns of the Inclusions -- Laminar Distribution -- Density of TDP-43Immunoreactive Inclusions -- Spatial Patterns of TDP-43Immunoreactive Inclusions -- Laminar Distribution of TDP-43Immunoreactive Inclusions -- Conclusion -- Acknowledgments.

References -- Effect of a Specific MammalianDNA Polymerase α-Inhibitor,Dehydroaltenusin, on DNAReplication in Cultured Cells -- Abstract -- Abbreviations -- 1. Introduction -- 2. Production and Isolationof Dehydroaltenusin -- 3. Effect of Dehydroaltenusin on Polsand other DNA Metabolic Enzymes -- 4. Mode of Pol α Inhibitionby Dehydroaltenusin -- 5. Effect of Dehydroaltenusinon Human Cancer Cell Growth -- 6. Inhibitory Properties of ehydroaltenusinon Human Cancer Cell Growth -- 7. Effect of Dehydroaltenusin on DNAReplication in NIH3T3 Cells -- 8. Discussion -- Conclusion -- Acknowledgments -- References -- Gel-Based Methods Using DNABindingZinc(II) Complexesfor the Detectionof DNA Mutations -- Abstract -- Introduction -- Zinc(II)-Cyclen -- Zinc(II)-Cyclen PolyacrylamideGel Electrophoresis -- Detection of Mutations in Uanine/Cytosine-Rich DNA Sequences -- Detection of Mutations in denine/Thymine-Rich DNA Sequences -- Zinc(II)-Phos-Tag -- Phos-Tag Technology -- Zinc(II)-Phos-Tag PolyacrylamideGel Electrophoresis -- SNP Genotyping -- Detection of Epigenetic MutationsInvolving Methylation of DNA -- Conclusion -- References -- DNA Mutationsand Genetic Coding -- Abstract -- Introduction -- Single-Base Deletions in DNA and ProteinChain Termination Coding -- Nucleotide Substitutions and Symmetriesof Degeneracy in the Genetic Code -- Conclusion -- References -- Nuclear DNA Replicationin Trypanosomatid Protozoa -- Abstract -- Introduction -- 1. General Aspects of Nuclear DNA Replication in HigherEukaryotes -- 2. Peculiarities of Kinetoplastida Protozoa: The FamilyTrypanosomatidae -- 2.1. The Cell Cycle in Trypanosomatids -- Nuclear Dna Replicationin Trypanosomatids -- 1. Assembly of the Pre-Replication Complex at the ReplicationOrigins -- 2. The Action of Toposiomerases at Replication Forks -- 3. DNA Polymerases: The DNA Replication Catalysis.

3.1. Trypanosomatid DNA Polymerases -- 4. Telomere Replication: The End-Replication Problem Is Solved -- 4.1. Trypanosomatid Telomere Replication -- Assembly of Chromatin and DNAReplication: A Tight Event -- Control of DNA Replication -- Nuclear Organization of DNA Replication -- Conclusion -- Acknowledgments -- References -- Index.

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