Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders.

Front Cover -- Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders -- Copyright -- Contents -- Preface -- Foreword -- Contributors -- Section-01 - Neurodevelopmental Disorders -- Chapter 1 - Overview Of The Role Of Environmental Factors In Neurodevelopmental Disorders -- INTRODUCTION -- EVIDENCE IMPLICATING ENVIRONMENTAL FACTORS -- FOR NEURODEVELOPMENTAL DISORDERS -- MECHANISMS BY WHICH ENVIRONMENTAL FACTORS INFLUENCE RISK OF NEURODEVELOPMENTAL DISORDERS -- CONCLUSIONS -- References -- Chapter 2 - Genetic Factors in Environmentally Induced Disease -- INTRODUCTION -- PARKINSON'S DISEASE -- AMYOTROPHIC LATERAL SCLEROSIS -- ALZHEIMER'S DISEASE -- CONCLUSIONS AND FUTURE DIRECTIONS -- References -- Chapter 3 - Fetal Alcohol Spectrum Disorders: Effects and Mechanisms of Ethanol on the Developing Brain -- INTRODUCTION -- FETAL ALCOHOL SPECTRUM DISORDERS (FASD) -- FASD PREVALENCE -- NEUROBEHAVIORAL DEFICITS IN FASD -- FASD AND BRAIN STRUCTURES -- ANIMAL MODELS FOR FASD -- MECHANISMS INVOLVED IN FASD -- EXPERIMENTAL TREATMENTS FOR FASD -- Acknowledgments -- References -- Chapter 4 - Prenatal Infection: Setting the Course of Brain Aging and Alzheimer's Disease? -- INTRODUCTION -- WHAT CHARACTERIZES ALZHEIMER'S DISEASE? -- ALZHEIMER'S DISEASE -- BASIC CELLULAR FUNCTIONS -- FROM AXONAL VARICOSITIES TO AXONAL DEGENERATION -- CONCLUSIONS -- References -- Chapter 5 - Neurobehavioral Effects of Air Pollution in Children -- INTRODUCTION -- EVIDENCE FROM EPIDEMIOLOGICAL RESEARCH -- EVIDENCE FROM ANIMAL RESEARCH -- BIOLOGICAL PATHWAYS -- EVALUATION OF THE EVIDENCE AND FUTURE RESEARCH DIRECTIONS -- CONCLUSIONS -- References -- Chapter 6 - The Role of Methylmercury Exposure in Neurodevelopmental and Neurodegenerative Disorders -- INTRODUCTION -- FETAL MINAMATA DISEASE AND ASSOCIATED DISORDERS.

ENVIRONMENTAL EPIDEMIOLOGY STUDIES OF LOW-LEVEL MEHG EXPOSURE: IMPROVING MEASUREMENTS AND METHODS -- OF MATERNAL FISH CONSUMPTION FOR CHILDHOOD OUTCOMES -- INSIGHTS ON NEUROBEHAVIORAL EFFECTS OF MEHG FROM ANIMAL MODEL STUDIES -- CROSS-SPECIES COMPARISONS OF MEHG NEURODEVELOPMENTAL EFFECTS -- MECHANISMS UNDERLYING MEHG-MEDIATED NEUROTOXICITY -- ENERGETICS, ALTERED CA2+ HOMEOSTASIS, AND PRODUCTION OF REACTIVE OXYGEN SPECIES -- EFFECTS OF MEHG ON MICROTUBULES AS A MECHANISM UNDERLYING DEVELOPMENTAL NEUROPATHOLOGY -- EFFECTS OF MEHG ON ASTROCYTES AND MICROGLIA -- NEURONAL SIGNALING -- DELAYED NEUROTOXICITY, NEURODEGENERATIVE DISEASE, AND INTERGENERATIONAL EFFECTS -- THE SOCIETAL AND HUMAN COSTS OF MEHG EXPOSURE -- Acknowledgments -- References -- Chapter 7 - Developmental Exposure to Lead: Overview and Integration of Neurobehavioral Consequences and Mediation -- INTRODUCTION AND FOCUS -- AND OCCUPATIONAL CONTAMINANT -- THE PERSISTENT QUESTION OF WHETHER ELEVATED LEAD EXPOSURE REDUCES IQ -- CHANGES IN LEARNING -- AS BEHAVIORAL MECHANISMS OF LEAD-INDUCED LEARNING AND IQ DEFICITS? -- PERSISTENCE OF DEVELOPMENTAL LEAD NEUROTOXICITY -- EN ROUTE TO MORE RELEVANT EVALUATIONS OF LEAD EXPOSURE AND PUBLIC HEALTH PROTECTION -- AN INTEGRATED SUMMARY AND HYPOTHESIZED RELATIONSHIPS OF THE CONSEQUENCES OF DEVELOPMENTAL LEAD EXPOSURE -- References -- Chapter 8 - Thyroid-Disrupting Chemicals as Developmental Neurotoxicants -- INTRODUCTION -- REGULATION OF TH ACTION -- REPRESENTATIVE TDCS AND MECHANISMS OF DISRUPTION -- DISRUPTION OF TH ACTION IN THE DEVELOPING BRAIN -- TH AND DEVELOPMENT OF THE AUDITORY SYSTEM -- CONCLUDING REMARKS -- References -- Chapter 9 - Environmental Factors in Neurodevelopmental Disorders: Summary and Perspectives -- References -- Section-02 - Neurodegenerative Disorders.

Chapter 10 - Overview of Neurodegenerative Disorders and Susceptibility Factors in Neurodegenerative Processes -- CLASSIFICATION -- MECHANISTIC CLUES -- COMPLEX DISORDERS -- LIFESTYLE MODIFIERS OF NEURODEGENERATIVE DISEASE RISK -- GENE-ENVIRONMENT INTERACTIONS -- EPIGENETICS -- CONCLUSIONS -- References -- Chapter 11 - Environmental Neurotoxins Linked to a Prototypical Neurodegenerative Disease -- INTRODUCTION -- ALS-PDC: A DECLINING OR DISAPPEARING ENVIRONMENTAL DISEASE -- ALS-PDC: LINKS TO CYCAD EXPOSURE -- ALS-PDC: LINKS TO CYCASIN -- ALS-PDC: LINKS TO L-BMAA -- ALS-PDC AND PHYTOSTEROLS -- PACIFIC REGION -- SUMMARIZING THE EVIDENCE: ALS-PDC AND CYCAD TOXINS -- Acknowledgment -- References -- Chapter 12 - Environmental Exposures and Risks for Parkinson's Disease -- INTRODUCTION -- ENVIRONMENTAL EXPOSURES -- DISCUSSION AND RECOMMENDATIONS -- References -- Chapter 13 - Parkinson's Disease: Mechanisms, Models, and Biological Plausibility -- DESCRIPTION OF PARKINSON'S DISEASE -- GENETIC ETIOLOGY OF PD -- ENVIRONMENTAL CONTRIBUTORS TO PD -- CLASSES OF ENVIRONMENTAL TOXICANTS ASSOCIATED WITH PD -- ANIMAL MODELS RELEVANT TO PD -- ALTERNATIVE MODELS -- EMERGING FRONTIERS AND FUTURE DIRECTIONS -- Acknowledgments -- References -- Chapter 14 - Genetic Models of Parkinson's Disease: Behavior, Signaling, and Pathological Features -- INTRODUCTION -- DESIRABLE CHARACTERISTICS OF AN ANIMAL MODEL FOR PD -- METHODS TO GENERATE GENETIC MODELS OF DISEASE -- GENETIC MOUSE MODELS FOR PD -- AUTOSOMAL RECESSIVE MUTATIONS -- CONCLUSIONS -- Acknowledgments -- References -- Chapter 15 - Alzheimer's Disease and the Search for Environmental Risk Factors -- INTRODUCTION -- HISTORY AND BIOLOGICAL CONTEXT -- CLINICAL AND STUDY DESIGN CONSIDERATIONS -- INFLUENCE STUDY DESIGN -- CONSIDERING RISK FACTORS -- EXAMPLES OF ENVIRONMENTAL RISK FACTORS -- CONCLUSIONS -- References.

Chapter 16 - Environmental Factors and Amyotrophic Lateral Sclerosis: What Do We Know? -- INTRODUCTION -- EPIDEMIOLOGY AND CHALLENGES TO THE STUDY OF AMYOTROPHIC LATERAL SCLEROSIS -- LATERAL SCLEROSIS -- ANTIOXIDANTS AND AMYOTROPHIC LATERAL SCLEROSIS -- FUTURE RESEARCH CONSIDERATIONS -- References -- Chapter 17 - Gene-Environment Interactions in Huntington's Disease -- AND MODELS -- NATURAL HISTORY OF HUNTINGTON'S DISEASE AND RELATED DISORDERS -- OF ENVIRONMENTAL FACTORS -- BIOLOGICAL FUNCTIONS OF THE HUNTINGTIN PROTEIN -- ENVIRONMENTAL INFLUENCES IN HUNTINGTON'S DISEASE: LIFESTYLE EFFECTS -- ENVIRONMENTAL INFLUENCES IN HUNTINGTON'S DISEASE: METALS -- CONCLUSIONS -- References -- Chapter 18 - Neuroinflammation in Neurological Dysfunction and Degeneration -- INFLAMMATION AND NEURODEGENERATION: CLUES FROM EPIDEMIOLOGICAL STUDIES -- DIRECT AND INDIRECT INDUCTION OF CHRONIC NEUROINFLAMMATION -- NEUROINFLAMMATION AND NEUROLOGICAL DYSFUNCTION: MODULATING BEHAVIOR -- NEUROINFLAMMATION IN NEURODEGENERATION: RECAPITULATING PROGRESSIVE NEURONAL DEATH -- THERAPEUTIC IMPLICATIONS: BREAKING THE CYCLE -- CONCLUSIONS -- References -- Chapter 19 - Late Neurological Effects of Early Environmental Exposures -- METHODOLOGICAL CHALLENGES -- EARLY-LIFE EXPOSURE AND LATER COGNITIVE STATUS -- EARLY-LIFE EXPOSURE AND LATER PSYCHIATRIC STATUS -- ADOLESCENCE AND ADULTHOOD -- DEVELOPMENTAL PROGRAMMING -- EARLY-LIFE LEAD EXPOSURE AND AD -- ENVIRONMENTAL EXPOSURES -- CONCLUSION -- References -- Chapter 20 - Environmental Factors in Neurodegenerative Disorders: Summary and Perspectives -- References -- Index.

Description based on publisher supplied metadata and other sources.

Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.