Cancer Chemotherapy and Biotherapy : Principles and Practice.

Cancer Chemotherapy and Biotherapy: Principles and Practice -- CONTENTS -- PREFACE -- ACKNOWLEDGMENTS -- CONTRIBUTORS -- Section I Basic Principles of Cancer Treatment -- Clinical Strategies for Cancer Treatment: The Role of Drugs -- Target Identifi cation and Drug Discovery -- Clinical Drug Development and Marketing Approval -- Principles of Pharmacokinetics -- Delivering Anticancer Drugs to Brain Tumors -- Pharmacogenetics -- Physical Barriers to Drug Delivery -- Section II Cytotoxic Agents -- Antifolates -- 5-Fluoropyrimidines -- Cytidine Analogues -- Purine Antimetabolites -- Hydroxyurea -- Antimitotic Drugs -- Alkylating Agents -- Platinum Analogues -- Bleomycin and Other Antitumor Antibiotics -- Topoisomerase I-Targeting Drugs -- Topoisomerase II Inhibitors: Anthracyclines -- Topoisomerase II Inhibitors: The Epipodophyllotoxins -- Asparaginase -- Section III Molecularly Targeted Therapies -- Proteasome Inhibitors -- Histone Deacetylase Inhibitors in Oncology -- Differentiating Agents -- Arsenic Trioxide -- Antibodies -- Inhibitors of Tumor Angiogenesis -- Epidermal Growth Factor Receptor Inhibitors -- HER2 Inhibitors -- Molecular Targeted Drugs -- Signaling Inhibitors: IGFR, PI3K Pathway, Embryonic Signaling Inhibitors, and Mitotic Kinase Inhibitors -- Section IV Immunologic Agents -- Cytokine Therapy for Cancer -- Cancer Vaccines -- Adoptive Cellular Therapies -- Thalidomide and Its Analogs in the Treatment of Hematologic Malignancies, Including Multiple Myeloma, and Solid Tumors -- Section V Hormonal Therapy -- Hormonal Therapy of Breast Cancer -- Hormone Therapy for Prostate Cancer -- Section VI Supportive Care -- Drug Therapy of Pain in Cancer Patients -- Hematopoietic Growth Factors -- Antinausea Medications -- Bisphosphonates and Other Bone-Targeted Therapies -- Intravenous Access and Catheter Management -- Section VII Survivorship.

Late Effects of Cancer Chemotherapy -- Infertility After Cancer Chemotherapy -- INDEX.

Updated to include the newest drugs and those currently in development, this Fifth Edition is a comprehensive reference on the preclinical and clinical pharmacology of anticancer agents. Organized by drug class, the book provides the latest information on all drugs and biological agents-their mechanisms of action, interactions with other agents, toxicities, side effects, and mechanisms of resistance. The authors explain the rationale for use of drugs in specific schedules and combinations and offer guidelines for dose adjustment in particular situations. This edition's introduction includes timely information on general strategies for drug usage, the science of drug discovery and development, economic and regulatory aspects of cancer drug development, and principles of pharmacokinetics. Eight new chapters have been added and more than twenty have been significantly revised. A companion website includes the fully searchable text and an image bank.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.