Fermentation Products : Proceedings of the Sixth International Fermentation Symposium Held in London, Canada, July 20-25 1980.

Front Cover -- Fermentation Products -- Copyright Page -- Table of Contents -- PREFACE -- GUEST EDITORIAL PROBLEMS AND TRENDS IN THE DEVELOPMENT OF NEW ANTIBIOTICS AND OTHER USEFUL MICROBIAL PRODUCTS -- Section I: New Aspects of Secondary Metabolites -- CHAPTER 1. POSSIBLE FUNCTIONS OF THE PEPTIDE ANTIBIOTICS TYROCIDINE AND GRAMICIDIN DURING SPORULATION -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- PEPTIDE SYNTHESIS AND THE INDUCTION OF SPORULATION -- THE ACTION OF TYROCIDINE IN VITRO -- THE ACTION OF GRAMICIDIN IN VITRO -- CONCLUDING REMARKS -- REFERENCES -- CHAPTER 2. THE ROLE OF SECONDARY METABOLISM IN PENICILLIUM BREVICOMPACTUM -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- RESULTS AND CONCLUSIONS OF EARLIER STUDIES -- EXPERIMENTS TO EXPLORE THE POSSIBILITY THAT MYCOPHENOLIC ACID IS A PRODUCT OF AN AERIAL MYCELIUM -- CURRENT THOUGHTS ABOUT THE ROLE OF MYCOPHENOLIC ACID IN P. BREVI COMPACTUM -- THE SITUATION WITH BREVIANAMIDE A (VI) -- ACKNOWLEDGEMENT -- REFERENCES -- CHAPTER 3. A STUDY OF SECONDARY GROWTH OF STREPTOMYCES GRISEORUBER -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- EXPERIMENTAL CONDITIONS -- RESULTS -- REFERENCES -- CHAPTER 4. ROLE OF PLASMID GENES IN AUREOTHRICIN PRODUCTION -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- BIOSYNTHETIC PATHWAY OF AUREOTHRICIN -- PHYSICAL CHARACTERIZATION OF PLASMIDS -- AUREOTHRICIN PRODUCTIVITY AND RELATED CHARACTERS OF MUTANTS (TABLE 1) -- GENERAL DISCUSSION -- REFERENCES -- CHAPTER 5. FUNCTION OF PLASMIDS IN PRODUCERS OF MACROLIDES -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- RESULTS AND DISCUSSION -- ACKNOWLEDGEMENTS -- REFERENCES -- CHAPTER 6. UNSTABLE PLEIOTROPIC MUTATION IN STREPTOMYCES LAVENDULAE -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- RESULTS AND DISCUSSION -- ACKNOWLEDGEMENT -- REFERENCES.

CHAPTER 7. LOCALIZATION OF ANTIMYCIN A AND MELANIN DETERMINANTS IN AUXOTROPHS OF Streptomyces sp. M-506 AND IN THEIR PROTOTROPHIC REVERTANTS -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- RESULTS -- DISCUSSION AND CONCLUSION -- REFERENCES -- CHAPTER 8. CHARACTERIZATION OF A PLASMID FROM BACILLUS BREVIS ATCC 9999 -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- ISOLATION OF CCC DNA -- CHARACTERIZATION OF CCC DNA -- ACKNOWLEDGEMENT -- REFERENCES -- CHAPTER 9. GENETICS OF PENICILLIN PRODUCING ORGANISMS -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- GENETICS AND BIOCHEMISTRY OF PENICILLIN PRODUCTION -- MUTATION AND DNA REPAIR -- ACKNOWLEDGEMENTS -- REFERENCES -- CHAPTER 10. PENICILLIN PRODUCTION BY RECOMBINANT STRAINS.OF Pénicillium chrysogenum OBTAINED BY FUSION OF PROTOPLASTS -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS AND DISCUSSION -- REFERENCES -- CHAPTER 11. FUSION OF PROTOPLASTS OF BACILLUS SPECIES -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS -- DISCUSSION -- REFERENCES -- CHAPTER 12. STUDIES ON THE NATURE OF VACUOLES IN PROTOPLASTS OF CLAVICEPS PURPUREA -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- METHODS -- RESULTS AND DISCUSSION -- CONCLUSION -- ACKNOWLEDGEMENT -- REFERENCES -- Section II: Antibiotics -- CHAPTER 13. CELL-FREE BIOSYNTHESIS OF MACROLIDES AND OTHER "POLYKETIDE" ANTIBIOTICS -- ABSTRACT -- KEYWORDS -- ACKNOWLEDGEMENT -- REFERENCES -- CHAPTER 14. CELL-FREE BIOSYNTHESIS OF PEPTIDE ANTIBIOTICS -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- SURVEY -- FERMENTATIONS - MULTIENZYME PRODUCTION -- MULTIENZYME INACTIVATION PROCESSES -- CATALYTIC ABILITIES OF MULTIENZYME SYSTEMS -- ACKNOWLEDGEMENT -- REFERENCES -- CHAPTER 15. ENZYMOLOGY OF CHLORAMPHENICOL BIOSYNTHESIS -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- PHENYLPROPANOID PRECURSORS -- REGULATION OF CHLORAMPHENICOL BIOSYNTHESIS.

CONTROL OF ARYLAMINE FORMATION -- ACKNOWLEDGEMENTS -- REFERENCES -- CHAPTER 16. BIOSYNTHESIS OF STREPTOMYCINS -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- ASSEMBLING OF THE STREPTOMYCIN MOLECULE -- ACKNOWLEDGEMENT -- REFERENCES -- CHAPTER 17. ENZYMATIC SYNTHESIS OF THE ANTIBIOTIC GRAMICIDIN S: KINETICS OF INHIBITION AND ENZYME DESTABILIZATION -- ABSTRACT -- KEYWORDS -- INTRODUCTION AND METHODOLOGY -- RESULTS AND DISCUSSION -- ACKNOWLEDGEMENT -- REFERENCES -- CHAPTER 18. TERMINAL STEPS OF PATULIN BIOSYNTHESIS IN PENICILLIUM URTICAE -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS -- DISCUSSION -- ACKNOWLEDGMENTS -- REFERENCES -- CHAPTER 19. SYNTHESIS OF ENNIATINS BY A MULTIENZYME -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- RESULTS AND DISCUSSION -- CONCLUSIONS -- ACKNOWLEDGEMENT -- REFERENCES -- CHAPTER 20. BIOSYNTHESIS OF DAUNORUBICIN GLYCOSIDES: ANALYSIS WITH BLOCKED MUTANTS -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- RESULTS AND DISCUSSION -- ACKNOWLEDGEMENT -- REFERENCES -- CHAPTER 21. FERMENTATION AND BIOSYNTHESIS OF SAGAMICIN AND RELATED AMINOGLYCOSIDES IN MICROMONOSPORA SAGAMIENSIS -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- STUDIES ON SAGAMICIN-GENTAMICIN BIOSYNTHESIS -- CONCLUSION -- REFERENCES -- CHAPTER 22. CHARACTERIZATION OF MUTANTS OF Streptomyces griseus DEREGULATED OR BLOCKED IN CANDICIDIN BIOSYNTHESIS: MOLECULAR MECHANISM OF CONTROL OF ANTIBIOTIC BIOSYNTHESIS -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS AND DISCUSSION -- REFERENCES -- CHAPTER 23. STUDY OF THE MOLECULAR MECHANISM OF PHOSPHATE CONTROL OF CANDICIDIN BIOSYNTHESIS USING PHOSPHATE- DEREGULATED MUTANTS -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS AND DISCUSSION -- REFERENCES -- CHAPTER 24. REGULATION BY AROMATIC AMINO ACIDS AT THE p-AMINOBENZOIC ACID SYNTHETASE LEVEL IN S.griseus -- ABSTRACT.

KEYWORDS -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS AND DISCUSSION -- REFERENCES -- CHAPTER 25. NITROGEN REGULATION OF PENICILLIN G BIOSYNTHESIS IN PENICILLIUM CHRYSOGENUM -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS -- DISCUSSION -- REFERENCES -- CHAPTER 26. CARBON CATABOLITE REPRESSION OF PENICILLIN BIOSYNTHESIS -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS -- DISCUSSION -- REFERENCES -- CHAPTER 27. REGULATION OF HOMOCITRATE SYNTHETASE BY LYSINE IN RELATION TO PENICILLIN G BIOSYNTHESIS -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS AND DISCUSSION -- REFERENCES -- CHAPTER 28. THE USE OF DIFFERENT 1-PHENYL-N-ALKANES FOR BENZYLPENICILLIN BIOSYNTHESIS BY PENICILLIUM CHRYSOGENUM -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- EXPERIMENTAL DESCRIPTION AND ANALYTICAL METHODS -- ANALYTICAL METHODS -- RESULTS -- CONCLUSION -- ACKNOWLEDGEMENT -- REFERENCES -- CHAPTER 29. ANALYSIS OF THE SPECTRUM OF SECONDARY METABOLITES OF AN INDUSTRIAL MACROLIDE-PRODUCING STRAIN OF STREPTOMYCES HYGROSCOPICUS -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- ISOLATION OF SHUNT METABOLITES AND CHEMICAL STRUCTURES -- BIOTRANSFORMATION OF DDAH-P1-II BY STRAIN NG 33 -- CONCLUSION -- ACKNOWLEDGEMENTS -- REFERENCES -- CHAPTER 30. STIMULATION OF LEUCOMYCIN PRODUCTION BY MAGNESIUM PHOSPHATE AND ITS RELEVANCE TO NITROGEN CATABOLITE REGULATION -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS AND DISCUSSION -- REFERENCES -- CHAPTER 31. REGULATION OF THE A40104 FERMENTATION-PRODUCTION OF A40104A, A PLEUROMUTILIN GLYCOSIDE ANTIBIOTIC -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS -- DISCUSSION -- ACKNOWLEDGEMENT -- REFERENCES -- CHAPTER 32. NITROGEN CATABOLITE REGULATION OF STREPTOTHRICIN BIOSYNTHESIS BY STREPTOMYCES NOURSEI JA 3890 b -- ABSTRACT.

KEYWORDS -- INTRODUCTION -- PHYSIOLOGICAL AND BIOCHEMICAL CHARACTERISITCS OF THE STRAIN -- BISTABILITY OF METABOLISM OF S. NOURSEI JA 3890b -- CONCLUSIONS -- REFERENCES -- CHAPTER 33. A NEW AMINOGLYCOSIDE SC,-ANTIBIOTIC: PRODUCING ORGANISM, FERMENTATION AND ITS BIOLOGICAL PROPERTIES -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS -- DISCUSSION -- ACKNOWLEDGEMENTS -- REFERENCES -- CHAPTER 34. STUDIES OF THE COSYNTHESIS AND METABOLIC REGULATION OF RIFAMYCIN SV -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- COSYNTHESIS, BIOCHEMICAL COPLEMENTION MAP, BIOASSAY AND CHARACTERIZATION OF INTEREDITATE -- STIMULATORY EFFECT OF NITRATE ON RIFAMYCIN BIOSYNTHESIS -- DISCUSSION -- REFERENCES -- Section III: Amino Acids, Vitamins and Nucleotides -- CHAPTER 35. REGULATION OF PRIMARY METABOLISM -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- CHANNELING OF PRECURSORS IN BRANCHED PATHWAYS -- GENERAL CONTROL OF AMINO ACID BIOSYNTHESIS IN FUNGI -- REFERENCES -- CHAPTER 36. AROMATIC AMINO ACID HYPERPRODUCING MUTANTS OF ESCHERICHIA COLI: BIOCHEMISTRY, GENETICS AND FERMENTATION KINETICS -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- MANIPULATION OF AROMATIC AMINO ACID METABOLISM IN E.COLI -- CONCLUSION -- ACKNOWLEDGEMENT -- REFERENCES -- CHAPTER 37. UTILISATION DE L 'ACTIVITE α-AMINOAMIDASIQUE D 'UNE BACTERIE NITRILASIQUE POUR LA PRODUCTION D' ACIDES α-AMINES STEREOSPECIFIQUES -- RESUME -- MOTS CLES -- INTRODUCTION -- ISOLEMENT DE MUTANTS ACETAMIDASEΘ -- SPECTRES NITRILASIQUE ET AMIDASIQUE D'UN MUTANT ACETAMIDASEΘ -- APPLICATIONS TECHNOLOGIQUES -- CONCLUSION ET PERSPECTIVES -- REFERENCES -- CHAPTER 38. ADVANCES IN STUDIES ON BREEDING OF AMINO ACID-PRODUCING STRAINS IN CHINA -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- ISOLATION AND SCREENING OF WILD-TYPE MICROORGANISMS -- AUXOTROPHIC MUTANTS -- AMINO ACID ANALOG-RESISTANT MUTANTS -- MULTIPLE MUTANTS.

CONCLUSION.

Advances in Biotechnology, Volume III: Fermentation Products is the third of a series of three volumes and is based on the proceedings of the Sixth International Fermentation Symposium (IFS-6) held in London, Ontario, Canada, 20-25 July 1980. This volume contains 87 papers organized into nine sections. The papers under Section I deal with developments in the field of secondary metabolism (functions of secondary metabolites in the producing organisms; roles of plasmids in the biosynthesis of secondary metabolites; and protoplast fusion in industrial microorganisms). Sections II to VII examine the fermentation of antibiotics; amino acids, vitamins, and nucleotides; microbial enzymes; products from immobilized cells and enzymes; mycotoxins; and biopolymers. The final two sections present studies on bioconversions. The volume also includes the invited keynote address of Professor Hamao Umezawa ""Problems and Trends in the Development of New Antibiotics and Other Useful Microbial Products"". This volume will be a valuable resource for students and researchers in industrial microbiology, biochemical engineering and related areas, as well as managers of biotechnology.

Description based on publisher supplied metadata and other sources.

Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.