In vitro and in vivo development of a topical drug for the treatment of equine skin cancer – based on naturally occurring and synthetically modified substances in plane bark.

Intro -- LIST OF ABBREVIATIONS -- SUMMARY -- ZUSAMMENFASSUNG -- 1. Introduction -- 1.1. The equine malignant melanoma -- 1.2. The equine sarcoid: an overview -- 1.3. Topical drug application -- 1.4. Naturally occurring substances in plane bark and their syntheticallymodified derivatives -- 1.5. Hypotheses and aims of the thesis -- 2. Manuscript I:Betulinic acid shows anticancer activity against equine melanoma cells andpermeates isolated equine skin in vitro -- 2.1. Supplemental data -- 3. Manuscript II:In vitro assessment of triterpenoids NVX-207 and betulinyl-bis-sulfamate asa topical treatment for equine skin cancer -- 4. Manuscript III:Concentration profiles and safety of topically applied betulinic acid andNVX-207 in eight healthy horses - A randomized, blinded, placebocontrolled,crossover pilot study -- 5. Manuscript IV:Effects of topically applied betulinic acid and NVX-207 on early stageequine melanoma - A prospective, randomized, double-blind, placebocontrolledpilot study -- 6. General discussion -- 6.1. Summarized findings -- 6.2. Interpretation of the findings -- 7. Major findings and conclusions -- 8. Future perspectives -- 9. References -- Affidavit -- Acknowledgements.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.