Inflammation and Immunity in Depression : Basic Science and Clinical Applications.

Front Cover -- Inflammation and Immunity in Depression: Basic Science and Clinical Applications -- Copyright -- Contents -- Contributors -- Preface -- Chapter 1: Depression-Associated Cellular Components of the Innate and Adaptive Immune System -- The Innate Immune System -- Role of Neutrophils in Innate Immunity and MDD -- Monocytes and MDD -- Innate Lymphoid Cells (ILCs) and Natural Killer (NK) Cells -- NK Cells and Depression -- The Adaptive Immune System and Its Components -- Summary -- References -- Chapter 2: Childhood Microbial Experience, Immunoregulation, Inflammation, and Adult Susceptibility to Psychosocial Stres ... -- Introduction -- Microbial Exposures and Human Evolution -- Microbiota -- Spores -- Environmental Microorganisms -- Old Infections -- Innate and Adaptive Immune Systems Regulate Microbiota -- Innate Immune System and Microbiota -- Adaptive Immune System and Microbiota -- Mechanisms of Immunoregulation by the Old Friends -- Immunoregulation by the Old Infections -- Immunoregulation by Organisms From the Natural Environment -- Immunoregulation by the Microbiota -- Endotoxin Tolerance -- Microbial Exosomes -- Lifestyle Changes That Impair Microbe-Induced Immunoregulation and That May Be Associated With Depression -- Perinatal and Early-Life Antibiotic Exposure -- Animal Experiments -- Human Data -- Caesarean Delivery -- Breast Feeding -- Diet -- Maternal Obesity -- Immigration -- Stress -- Depression -- Chronic Stress-Induced Inflammation in Depression -- Proinflammatory Cytokines Induce Depression -- Depression is Associated With Autoimmune, Allergic and Inflammatory Bowel Disorders -- Antidepressant Effects of Anti-Inflammatory and Immunoregulatory Treatments -- Microbiota in Human Depression -- Animal Data -- Microbial Metabolites and the Brain -- Conclusions -- References.

Chapter 3: Neuroendocrine Abnormalities in Major Depression: An Insight Into Glucocorticoids, Cytokines, and the Kynureni ... -- Introduction -- The HPA Axis and Glucocorticoid Abnormalities in Major Depression -- Glucocorticoid Resistance -- Inflammation and Cytokine Dysregulation in Major Depression -- Neuroinflammation -- Serotonin-Kynurenine Hypothesis and Neurodegeneration -- Summary and Conclusion -- Future Directions and Translational Significance -- References -- Chapter 4: Neurovascular Dysfunction With BBB Hyperpermeability Related to the Pathophysiology of Major Depressive Disorder -- Introduction -- Neurovascular Dysfunction -- Blood-Brain Barrier Unit Hyperpermeability -- Theoretical Integration With Oxidative and Neuroinflammatory Mechanisms -- Oxidative Stress -- Neuroinflammation -- Conclusions -- References -- Further Reading -- Chapter 5: The Impact of Inflammation on Brain Function and Behavior in Rodent Models of Affective Disorders -- Introduction -- Stress, Inflammation and Depressive-Like Behaviors in Rodent Models -- Cytokine-Induced Modulation of HPA-Axis Activity in Rodent Models -- LPS-Mediated Behavioral Alterations in Rodent Models -- Cytokine-Induced Behavioral Alterations in Rodent Models -- Mediators of Inflammation Induced Depressive-Like Behaviors -- Cytokine-Induced Dysregulation of Serotonin (5-HT) Signaling -- Cytokine-Induced Activation of Indoleamine 2,3 Dioxygenase (IDO) -- Cytokine-Induced Elevation of Kynurenine Metabolites and Oxidative Stress -- Altered Hippocampal Neurogenesis and Neural Plasticity -- Role of Gut-Microbiota-Brain Axis in Inflammation-Induced Depression -- Sexual Dimorphism Associated With Inflammation-Induced Depression -- Conclusions -- References -- Further Reading -- Chapter 6: Neurogenesis, Inflammation, and Mental Health -- Introduction -- IL-1α and IL-1β.

IL-1β Induced by Lipopolysaccharide-Activated Human Monocyte-Derived Macrophages -- IL-6 -- Microglial-Derived IL-6-Family Cytokines -- IL-4, IL-10, and IL-11 -- IL-4- and IL-10-Treated Microglia -- IFN-α and IFN-γ -- IFN-γ-TM -- TNF-α -- TNF-α Induced by LPS-MDM -- Conclusions and Future Directions -- References -- Chapter 7: The Roles of T Cells in Clinical Depression -- An Active Role for T Cells in the Modulation of Inflammation Associated Depression -- T Cell Subtypes and Their Functional Phenotype in Maladaptive Immune Responses During Clinical Depression -- T Cell Subtypes and Their Functional Phenotype in Adaptive Immune Responses During Clinical Depression -- Regulation of T Cell Responses in Clinical Depression -- Current Challenges for in vitro and in vivo Measurement of T Cells and Their Functionality -- Concluding Remarks and Future Outlook -- Acknowledgment -- Conflict Of Interest -- References -- Chapter 8: Do Chemokines Have a Role in the Pathophysiology of Depression? -- Introduction -- What Are Chemokines? -- Nomenclature of Chemokines -- Structure of Chemokines and Chemokines Receptors, and Ligand Expression in CNS -- Biological Role of Various Chemokines in CNS Modulation -- CC Chemokines in CNS -- CXC Chemokines in CNS -- CX3C Chemokine in CNS -- Mechanistic Links Between Chemokines Action and Development of Depression -- Neuroinflammatory Action of Chemokines -- Role of Chemokines During Brain Development and in Neuronal Plasticity -- Modulation of Neurotransmission by Chemokines -- Regulation of HPA Axis and Neuroendocrine Functions by Chemokines -- Discussion -- Concluding Remarks -- Conflict of Interest Statement -- References -- Chapter 9: Inflammasomes Action as an Important Mechanism in Experimental and Clinical Depression -- Introduction -- What Are Inflammasomes? -- Molecular Structure of Inflammasomes.

NLRP3 Inflammasome-Mediated Inflammatory Pathways in the Brain -- Mechanistic Link Between Inflammasomes Action and Development of Depressive-Like Behavior -- Discussion -- Concluding Remarks -- Conflict of Interest Statement -- References -- Chapter 10: Pathways Driving Neuroprogression in Depression: The Role of Immune Activation -- Introduction -- Depression as a Neuroprogressive Disorder -- Peripheral Immune Activation in Depression -- Evidence -- Possible Sources of Peripheral Immune Activation in Depression -- From Peripheral Immune Activation to Neuroinflammation -- Immune-Inflammatory Mechanisms and Neuroprogression in Depression -- Direct Mechanisms -- Indirect Mechanisms -- The Role of Indoleamine 2,3 Dioxygenase (IDO) and the Tryptophan Catabolism (TRYCAT) Pathway -- Oxidative and Nitrosative Stress (O&amp -- NS) -- Mitochondrial Dysfunction -- Neural Plasticity and the Role of Brain Derived Neurotrophic Factor -- Other Indirect Pathways -- Inflammation and the Phenotypic Heterogeneity of Depression -- Therapeutic Perspectives -- Conclusions -- Acknowledgments -- Conflicts Of Interest -- References -- Further Reading -- Chapter 11: Gene Expression of Inflammation Markers in Depression -- Gene Expression Patterns of Immune Dysregulations in the Brain -- Overlap of Gene Expression Markers of Inflammation Across Psychiatric Disorders -- Gene Expression Pattern of Immune Dysregulation in the Periphery -- Peripheral Inflammation in Depression With Medical Comorbidity -- Depression and Hepatitis C -- Depression and Cancer -- Depression and Asthma -- Depression and Cardiometabolic Disorders -- Inflammation as a Predictor of a Treatment Response -- Anti-inflammatory Therapy From a Gene Expression Perspective -- Summary and Conclusions -- References.

Chapter 12: Neuroimmunopharmacology at the Interface of Inflammation and Pharmacology Relevant to Depression -- Introduction -- Classical Antidepressants -- Stress and Cortisol in Inflammation-Associated Depression -- Nonsteroidal Antiinflammatory Drugs -- Anticytokine Antibody Therapy -- Minocycline as an Antiinflammatory Agent -- NMDA Receptor Antagonists: Relevance to Inflammation-Associated Depression -- Cannabinoids Antiinflammatory Potential -- Conclusions -- References -- Chapter 13: The Gut-Brain-Microbe Interaction: Relevance in Inflammation and Depression -- Gut Microbiome -- Gut-Brain Axis and Microbiota -- Depression, Inflammation and the Gut Microbiome -- Animal Intervention Studies -- Human Intervention Studies -- Clinical Applications -- Conclusions -- References -- Chapter 14: Childhood Trauma and Adulthood Immune Activation -- Introduction: Childhood Trauma and Depression -- Physiological Effects of Childhood Adversities: From Stress to Immune Activation -- Evidence Linking Early Stress and Immune Activation in Early Life/Childhood -- Evidence Linking Early Stress and Immune Activation in Adulthood -- From Immune Activation to Depression -- Is Immune Activation in Depression Due to Early-Life Stress? -- Inflammation, Depression and Physical Comorbidities -- How Does Immune Activation Lead to Depression? -- Peripheral and Central Inflammation -- Mechanisms Linking Inflammation to Depression -- Childhood Trauma and Novel Treatments and Interventions Targeting Immune System -- Acknowledgments -- References -- Chapter 15: Stress, Maltreatment, Inflammation, and Functional Brain Changes in Depression -- Stress System -- HPA Axis and Homeostasis -- Glucocorticoids in Depression -- Stress and Maltreatment -- Immune System -- Inflammation and MDD -- Tryptophan Metabolic Pathway -- Brain Imaging of Depression -- Structural Changes in MDD.

Functional Changes in MDD.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.