The Role of MicroRNAs in Controlling Protein Expression Noise.

Intro -- 1 Noise arising fromprotein production isminimized for noise-prone genes -- 1.1 Introduction -- 1.2 Results -- 2 microRNA control of protein expression noise -- 2.1 Introduction -- 2.2 Mathematical model of microRNA noise effects -- 2.3 Experimental validation of microRNA noise effects -- 2.3.1 Experimental validation of noise effects for miR-20a in mouse embryonic stem cells -- 2.3.2 Generality of intrinsic noise reduction for microRNAs and other post-transcriptional repressors -- 2.3.3 Additional extrinsic noise from individual and mixed microRNA pools -- 2.4 microRNA noise effects in endogenous target situations -- 2.5 microRNAs predominantly increase production ratios -- 2.6 Noise-sensitive genes are enriched for microRNA regulation -- 3 Conclusions and Outlook -- 3.1 Protein expression noise in mammalian cells -- 3.2 microRNA control of protein expression noise in mammalian cells -- 4 Materials &amp -- Methods -- 4.1 Bioinformatics -- 4.2 Experiments -- 4.3 Measuring fluorescent protein variability on a flow cytometry -- 4.4 GO Term microRNA regulation -- References.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.