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Computational Immunology : Basics.

By: Material type: TextTextPublisher: Milton : Taylor & Francis Group, 2019Copyright date: ©2020Edition: 1st edDescription: 1 online resource (349 pages)Content type:
  • text
Media type:
  • computer
Carrier type:
  • online resource
ISBN:
  • 9781351025539
Subject(s): Genre/Form: Additional physical formats: Print version:: Computational ImmunologyDDC classification:
  • 616.079
LOC classification:
  • QR181 .G467 2020
Online resources:
Contents:
Cover -- Half Title -- Title Page -- Copyright Page -- Dedication -- Table of Contents -- Preface -- Acknowledgments -- Author -- About the Book -- List of Abbreviations -- Chapter 1: Overview of Immunology and Computational Immunology -- 1.1 Introduction -- 1.2 History of the Science of Immunology -- 1.3 Innate Immune System -- 1.3.1 Physical Barriers -- 1.3.2 Cellular Components -- 1.3.3 Cytokines -- 1.3.4 The Complement System -- 1.3.5 Cellular Receptors -- 1.3.5.1 Toll-Like Receptor -- 1.3.5.2 NOD-Like Receptors -- 1.3.5.3 Plasma Proteins -- 1.4 Adaptive Immune System -- 1.5 Clonal Selection -- 1.6 Antigen -- 1.7 Immune Cells and Organs -- 1.8 Antigen Processing and Presentation -- 1.9 Antibody-Dependent Cellular Cytotoxicity -- 1.10 Immunodeficiencies -- 1.11 Immune Tolerance and Autoimmunity -- 1.12 Hypersensitivity/Allergy -- 1.13 Infection -- 1.14 Vaccination -- 1.15 Tracing the Origin of the Applications of the Science of Computation in Science, Biology, and Immunology -- 1.16 History of Computational Immunology -- 1.17 The Current Developments of Computational Immunology -- 1.18 Different Immunological Databases -- 1.19 Computational Immunology and the Biology of Disease -- 1.20 Discussions -- References -- Chapter 2: Immune Organs and Cells, Antigen, and Antibody, B-Cell, and T-Cell Development -- 2.1 Introduction -- 2.2 Immune Cells and Organs -- 2.2.1 Stem Cells -- 2.2.1.1 Computational Immunology and Haematopoiesis -- 2.2.2 Cells of the Immune System -- 2.2.2.1 Lymphocytes -- 2.2.2.2 Lymphocytes Types and Function -- 2.2.2.3 Monocytes -- 2.2.2.4 Macrophages -- 2.2.2.5 Granulocytes -- 2.2.2.6 Mast Cells -- 2.2.2.7 Dendritic Cells -- 2.2.2.8 Primary Lymphoid Organs -- 2.2.2.9 Secondary Lymphoid Organs -- 2.3 Antigen -- 2.3.1 Epitopes -- 2.3.2 Paratope -- 2.3.3 Immunogenicity -- 2.3.4 Antigenicity -- 2.3.5 Types of Antigen.
2.3.6 Antigen Receptors -- 2.3.6.1 B-Cell Receptors -- 2.3.6.2 T-Cell Receptors -- 2.3.6.3 Preformed Receptors -- 2.3.6.4 Comparison of BCR and TCR -- 2.4 Immunoglobulin -- 2.4.1 Immunoglobulin Structure -- 2.4.2 Immunoglobulin Function -- 2.4.2.1 Antigen Binding -- 2.4.2.2 Effector Functions -- 2.4.3 Immunoglobulin Classes -- 2.4.4 Immunoglobulin Types and Subtypes -- 2.4.5 Isotypes -- 2.4.5.1 IgG -- 2.4.5.2 IgM -- 2.4.5.3 IgA -- 2.4.5.4 IgD -- 2.4.5.5 IgE -- 2.4.6 Antigenic Determinants -- 2.4.6.1 Isotype -- 2.4.6.2 Idiotype -- 2.4.6.3 Allotype -- 2.4.7 Antigen-Antibody Reactions: Lock and Key Concept -- 2.4.8 Non-covalent Bonds -- 2.4.9 Affinity -- 2.4.10 Avidity -- 2.4.11 Specificity -- 2.4.12 Cross Reactivity -- 2.5 B-Cell Development -- 2.5.1 Antigen-Independent Phase -- 2.5.1.1 Pro- and Pre-B Cells -- 2.5.1.2 Immature B Cells -- 2.5.1.3 Full Maturation -- 2.5.1.4 Selection -- 2.5.1.5 B-1 B and B-2B Cells -- 2.5.2 Antigen-Dependent Phase -- 2.5.2.1 B-Cell Co-receptor Complex -- 2.6 Activation of B Cells -- 2.6.1 Thymus-Dependent Activation and Signalling -- 2.6.2 Thymus-Independent Activation -- 2.6.3 Activation Signal -- 2.6.4 Role of TH Cells in B-Cell Responses -- 2.6.5 Signals by TH Cell Cytokines -- 2.6.6 Germinal Centre Reaction -- 2.6.7 Somatic Hypermutation -- 2.6.8 Affinity Maturation -- 2.6.9 Positive Selection -- 2.6.10 Class Switching -- 2.6.11 Generation of Plasma Cells and Memory Cells -- 2.6.12 Memory Cells -- 2.6.13 Immunologic Memory -- 2.6.14 Molecules That Play Roles in B-Cell Development -- 2.6.15 B-Cell Development and Abnormalities -- 2.7 Antibody Diversity -- 2.7.1 Genes of Immunoglobulin Family -- 2.7.2 Recombinational Joining of VJ and VDJ Segments -- 2.7.2.1 Light Chain Rearrangements -- 2.7.2.2 Heavy Chain Rearrangements -- 2.7.2.3 Junctional Flexibility -- 2.7.2.4 P-Region Nucleotide.
2.7.2.5 N-Region Nucleotide Insertion -- 2.7.2.6 Somatic Hypermutation -- 2.7.2.7 Combinatorial Association of Heavy and Light Chains -- 2.7.2.8 Multi-specificity -- 2.7.2.9 Alternative Splicing -- 2.7.2.10 Regulation of Ig Gene Transcription -- 2.7.2.11 Cytokines Involved in Class Switching -- 2.7.2.12 Production of Immunoglobulin -- 2.7.2.13 Class or Isotype Switching -- 2.7.2.14 Allelic Exclusion -- 2.8 Immunoglobulin Superfamily Members -- 2.9 T-Cell Maturation -- 2.9.1 Maturation and Selection of T Cells -- 2.9.2 Role of CD4 and CD8 in Selection -- 2.9.3 .d T Cells -- 2.9.4 T Regulatory Cells -- 2.9.5 NKT Cells -- 2.9.6 T-Cell Activation -- 2.9.7 Signalling -- 2.9.8 Co-stimulatory Signal -- 2.9.9 T Cell Anergy -- 2.9.10 T-Cell Differentiation -- 2.10 The Structure of the T-Cell Receptor Complex -- 2.10.1 T-Cell Receptors, Triggering a Response -- 2.10.2 TCR Co-receptor -- 2.10.3 CD4/CD8 -- 2.10.4 CD2 -- 2.10.5 LFA-1 -- 2.10.6 CD28 -- 2.10.7 CTLA-4 -- 2.10.8 CD45R -- 2.10.9 CD5 -- 2.11 Function of TCR -- 2.12 TCR Genes and Its Organisation -- 2.12.1 TCR Gene Rearrangements -- 2.12.2 Allelic Exclusion of TCR Genes -- 2.12.3 TCR Diversity -- 2.12.4 Diseases Associated with TCR Defective Function -- 2.13 Computational Immunology and Study of Immune Cells -- 2.14 Discussion -- References -- Chapter 3: Antigen Processing and Presentation -- 3.1 Introduction -- 3.2 Major Histocompatibility Complex -- 3.3 Classes of MHC Molecules -- 3.4 Associated Molecules Involved in Antigen Processing and Presentation Pathway -- 3.5 Functions of MHC -- 3.6 MHC and Disorders -- 3.7 Antigen Presentation and Processing -- 3.7.1 MHC Class I Antigen Presentation -- 3.7.2 MHC Class II Antigen Presentation -- 3.7.3 Peptides Binding to MHC Class I Molecules -- 3.7.4 Peptide Binding to MHC Class II Molecules -- 3.7.5 Epitope Selection and Antigen Processing.
3.8 Endocytic Pathway or Exogenous Antigens -- 3.9 Processing of Endogenous Antigens or the Cytosolic Pathway -- 3.10 Cross Presentation of Exogenous Antigens -- 3.11 Presentation of Non-peptide Antigens -- 3.12 Computational Immunology and Antigen Processing and Presentation -- 3.13 Discussion -- References -- Chapter 4: Innate Immunity -- 4.1 Introduction -- 4.2 Barriers to Infection -- 4.2.1 Physical Barriers -- 4.2.2 Chemical Barriers -- 4.2.3 Antimicrobial Peptides -- 4.2.4 Biological Barriers -- 4.2.5 Endocytosis and Phagocytosis -- 4.2.6 Pathogen-Associated Molecular Patterns -- 4.2.7 Pattern Recognition Receptors -- 4.2.7.1 Cellular PRRs -- 4.2.7.2 TLRs -- 4.2.7.3 RLR Family -- 4.2.7.4 NLR Family -- 4.2.8 Soluble Molecules in Defence -- 4.2.8.1 Cytokines -- 4.2.8.2 Chemokines -- 4.2.8.3 Complement System -- 4.2.8.4 Crosstalk between the Adaptive and Innate Immune Systems -- 4.2.8.5 Computational Immunology and Innate Immune System -- 4.3 Discussion -- References -- Chapter 5: Inflammation -- 5.1 Introduction -- 5.2 Mechanism -- 5.3 PAMPs and DAMPs -- 5.4 TLRs -- 5.4.1 Signalling through MyD88-Dependent Activation by TLRs -- 5.5 RIG-I-Like Receptors -- 5.6 NOD-Like Receptors -- 5.7 Tumour Necrosis Factor -- 5.8 Selectins and Integrins -- 5.9 G Protein-Coupled Receptors -- 5.10 C5a Receptor and Formyl Peptide Receptors -- 5.11 Fc Receptors -- 5.12 Acute Phase Proteins (APPs) -- 5.13 Acute Phase Response -- 5.14 C-Reactive Protein -- 5.15 Acute Inflammation -- 5.16 Chronic Inflammation -- 5.17 Inflammation and Disease -- 5.18 Computational Immunology and Inflammation Biology -- 5.19 Discussion -- References -- Chapter 6: Infection and Immunity -- 6.1 Introduction -- 6.2 Infectious Diseases: A Historical Perspective -- 6.3 Viruses -- 6.3.1 DNA Viruses (Classes I and II) -- 6.3.2 RNA Viruses (Classes III and VI).
6.3.3 Immune System and Response to Viral Infection -- 6.3.4 Regulation of Immune Effector Activity during Virus Infection -- 6.3.5 Evading the Immune Responses -- 6.3.6 Strategies for Vaccination and Computational Immunology -- 6.4 Bacteria -- 6.4.1 Gut Microbiome -- 6.4.2 Immune Response to Bacterial Infection -- 6.4.3 Evading the Immune System -- 6.4.4 Bacterial Infection and Major Associated Problems -- 6.5 Fungi -- 6.5.1 Immune System and Fungal Infection -- 6.5.2 How Fungus Evades the Immune System -- 6.5.3 Fungal Vaccination Strategies -- 6.6 Helminths -- 6.6.1 Effector Immune Mechanisms against Helminths -- 6.6.2 Immune Response Evasion -- 6.6.3 Helminths and Allergic and Autoimmune Diseases -- 6.6.4 Vaccine Development -- 6.7 Protozoa -- 6.7.1 Protozoan Infection and the Immune System -- 6.7.2 Evading the Immune System -- 6.7.3 Immunisation/Vaccination -- 6.8 Arthropod-Borne Diseases -- 6.8.1 Malaria -- 6.8.2 Trypanosomiasis -- 6.8.3 Leishmaniasis -- 6.8.4 Post-Kala-Azar Dermal Leishmaniasis -- 6.8.5 Filariasis -- 6.8.6 Onchocerciasis -- 6.8.7 Dengue -- 6.8.8 Rickettsias and Plague -- 6.8.9 Plague -- 6.8.10 Arboviruses -- 6.8.11 Chikungunya -- 6.8.12 Vector-Borne Diseases in Animals -- 6.9 Prions and Diseases -- 6.10 Understanding Host-Parasite Interaction -- 6.11 Molecular Mimicry -- 6.12 The HIV Virus -- 6.12.1 Infection -- 6.12.2 HIV and Factors That Influence Infection -- 6.12.2.1 Host Factors -- 6.12.2.2 Viral Factors -- 6.12.3 Clinical Features -- 6.12.4 Prophylaxis -- 6.12.5 Detection -- 6.12.6 Disease Management -- 6.12.7 Recent Developments in AIDS Vaccine -- 6.13 Computational Immunology and the Biology of Infection -- 6.14 Discussion -- References -- Chapter 7: Transplantation Immunology -- 7.1 Introduction -- 7.2 Organ Transplantation: A Historical Perspective.
7.3 Histocompatibility and Transplantation Biology from a Historical Perspective.
Summary: The first volume describes detailed complexity of the immune system in human and in invertebrates. It also gives an idea of different computational tools and techniques in understanding the complexity of immune systems.
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Cover -- Half Title -- Title Page -- Copyright Page -- Dedication -- Table of Contents -- Preface -- Acknowledgments -- Author -- About the Book -- List of Abbreviations -- Chapter 1: Overview of Immunology and Computational Immunology -- 1.1 Introduction -- 1.2 History of the Science of Immunology -- 1.3 Innate Immune System -- 1.3.1 Physical Barriers -- 1.3.2 Cellular Components -- 1.3.3 Cytokines -- 1.3.4 The Complement System -- 1.3.5 Cellular Receptors -- 1.3.5.1 Toll-Like Receptor -- 1.3.5.2 NOD-Like Receptors -- 1.3.5.3 Plasma Proteins -- 1.4 Adaptive Immune System -- 1.5 Clonal Selection -- 1.6 Antigen -- 1.7 Immune Cells and Organs -- 1.8 Antigen Processing and Presentation -- 1.9 Antibody-Dependent Cellular Cytotoxicity -- 1.10 Immunodeficiencies -- 1.11 Immune Tolerance and Autoimmunity -- 1.12 Hypersensitivity/Allergy -- 1.13 Infection -- 1.14 Vaccination -- 1.15 Tracing the Origin of the Applications of the Science of Computation in Science, Biology, and Immunology -- 1.16 History of Computational Immunology -- 1.17 The Current Developments of Computational Immunology -- 1.18 Different Immunological Databases -- 1.19 Computational Immunology and the Biology of Disease -- 1.20 Discussions -- References -- Chapter 2: Immune Organs and Cells, Antigen, and Antibody, B-Cell, and T-Cell Development -- 2.1 Introduction -- 2.2 Immune Cells and Organs -- 2.2.1 Stem Cells -- 2.2.1.1 Computational Immunology and Haematopoiesis -- 2.2.2 Cells of the Immune System -- 2.2.2.1 Lymphocytes -- 2.2.2.2 Lymphocytes Types and Function -- 2.2.2.3 Monocytes -- 2.2.2.4 Macrophages -- 2.2.2.5 Granulocytes -- 2.2.2.6 Mast Cells -- 2.2.2.7 Dendritic Cells -- 2.2.2.8 Primary Lymphoid Organs -- 2.2.2.9 Secondary Lymphoid Organs -- 2.3 Antigen -- 2.3.1 Epitopes -- 2.3.2 Paratope -- 2.3.3 Immunogenicity -- 2.3.4 Antigenicity -- 2.3.5 Types of Antigen.

2.3.6 Antigen Receptors -- 2.3.6.1 B-Cell Receptors -- 2.3.6.2 T-Cell Receptors -- 2.3.6.3 Preformed Receptors -- 2.3.6.4 Comparison of BCR and TCR -- 2.4 Immunoglobulin -- 2.4.1 Immunoglobulin Structure -- 2.4.2 Immunoglobulin Function -- 2.4.2.1 Antigen Binding -- 2.4.2.2 Effector Functions -- 2.4.3 Immunoglobulin Classes -- 2.4.4 Immunoglobulin Types and Subtypes -- 2.4.5 Isotypes -- 2.4.5.1 IgG -- 2.4.5.2 IgM -- 2.4.5.3 IgA -- 2.4.5.4 IgD -- 2.4.5.5 IgE -- 2.4.6 Antigenic Determinants -- 2.4.6.1 Isotype -- 2.4.6.2 Idiotype -- 2.4.6.3 Allotype -- 2.4.7 Antigen-Antibody Reactions: Lock and Key Concept -- 2.4.8 Non-covalent Bonds -- 2.4.9 Affinity -- 2.4.10 Avidity -- 2.4.11 Specificity -- 2.4.12 Cross Reactivity -- 2.5 B-Cell Development -- 2.5.1 Antigen-Independent Phase -- 2.5.1.1 Pro- and Pre-B Cells -- 2.5.1.2 Immature B Cells -- 2.5.1.3 Full Maturation -- 2.5.1.4 Selection -- 2.5.1.5 B-1 B and B-2B Cells -- 2.5.2 Antigen-Dependent Phase -- 2.5.2.1 B-Cell Co-receptor Complex -- 2.6 Activation of B Cells -- 2.6.1 Thymus-Dependent Activation and Signalling -- 2.6.2 Thymus-Independent Activation -- 2.6.3 Activation Signal -- 2.6.4 Role of TH Cells in B-Cell Responses -- 2.6.5 Signals by TH Cell Cytokines -- 2.6.6 Germinal Centre Reaction -- 2.6.7 Somatic Hypermutation -- 2.6.8 Affinity Maturation -- 2.6.9 Positive Selection -- 2.6.10 Class Switching -- 2.6.11 Generation of Plasma Cells and Memory Cells -- 2.6.12 Memory Cells -- 2.6.13 Immunologic Memory -- 2.6.14 Molecules That Play Roles in B-Cell Development -- 2.6.15 B-Cell Development and Abnormalities -- 2.7 Antibody Diversity -- 2.7.1 Genes of Immunoglobulin Family -- 2.7.2 Recombinational Joining of VJ and VDJ Segments -- 2.7.2.1 Light Chain Rearrangements -- 2.7.2.2 Heavy Chain Rearrangements -- 2.7.2.3 Junctional Flexibility -- 2.7.2.4 P-Region Nucleotide.

2.7.2.5 N-Region Nucleotide Insertion -- 2.7.2.6 Somatic Hypermutation -- 2.7.2.7 Combinatorial Association of Heavy and Light Chains -- 2.7.2.8 Multi-specificity -- 2.7.2.9 Alternative Splicing -- 2.7.2.10 Regulation of Ig Gene Transcription -- 2.7.2.11 Cytokines Involved in Class Switching -- 2.7.2.12 Production of Immunoglobulin -- 2.7.2.13 Class or Isotype Switching -- 2.7.2.14 Allelic Exclusion -- 2.8 Immunoglobulin Superfamily Members -- 2.9 T-Cell Maturation -- 2.9.1 Maturation and Selection of T Cells -- 2.9.2 Role of CD4 and CD8 in Selection -- 2.9.3 .d T Cells -- 2.9.4 T Regulatory Cells -- 2.9.5 NKT Cells -- 2.9.6 T-Cell Activation -- 2.9.7 Signalling -- 2.9.8 Co-stimulatory Signal -- 2.9.9 T Cell Anergy -- 2.9.10 T-Cell Differentiation -- 2.10 The Structure of the T-Cell Receptor Complex -- 2.10.1 T-Cell Receptors, Triggering a Response -- 2.10.2 TCR Co-receptor -- 2.10.3 CD4/CD8 -- 2.10.4 CD2 -- 2.10.5 LFA-1 -- 2.10.6 CD28 -- 2.10.7 CTLA-4 -- 2.10.8 CD45R -- 2.10.9 CD5 -- 2.11 Function of TCR -- 2.12 TCR Genes and Its Organisation -- 2.12.1 TCR Gene Rearrangements -- 2.12.2 Allelic Exclusion of TCR Genes -- 2.12.3 TCR Diversity -- 2.12.4 Diseases Associated with TCR Defective Function -- 2.13 Computational Immunology and Study of Immune Cells -- 2.14 Discussion -- References -- Chapter 3: Antigen Processing and Presentation -- 3.1 Introduction -- 3.2 Major Histocompatibility Complex -- 3.3 Classes of MHC Molecules -- 3.4 Associated Molecules Involved in Antigen Processing and Presentation Pathway -- 3.5 Functions of MHC -- 3.6 MHC and Disorders -- 3.7 Antigen Presentation and Processing -- 3.7.1 MHC Class I Antigen Presentation -- 3.7.2 MHC Class II Antigen Presentation -- 3.7.3 Peptides Binding to MHC Class I Molecules -- 3.7.4 Peptide Binding to MHC Class II Molecules -- 3.7.5 Epitope Selection and Antigen Processing.

3.8 Endocytic Pathway or Exogenous Antigens -- 3.9 Processing of Endogenous Antigens or the Cytosolic Pathway -- 3.10 Cross Presentation of Exogenous Antigens -- 3.11 Presentation of Non-peptide Antigens -- 3.12 Computational Immunology and Antigen Processing and Presentation -- 3.13 Discussion -- References -- Chapter 4: Innate Immunity -- 4.1 Introduction -- 4.2 Barriers to Infection -- 4.2.1 Physical Barriers -- 4.2.2 Chemical Barriers -- 4.2.3 Antimicrobial Peptides -- 4.2.4 Biological Barriers -- 4.2.5 Endocytosis and Phagocytosis -- 4.2.6 Pathogen-Associated Molecular Patterns -- 4.2.7 Pattern Recognition Receptors -- 4.2.7.1 Cellular PRRs -- 4.2.7.2 TLRs -- 4.2.7.3 RLR Family -- 4.2.7.4 NLR Family -- 4.2.8 Soluble Molecules in Defence -- 4.2.8.1 Cytokines -- 4.2.8.2 Chemokines -- 4.2.8.3 Complement System -- 4.2.8.4 Crosstalk between the Adaptive and Innate Immune Systems -- 4.2.8.5 Computational Immunology and Innate Immune System -- 4.3 Discussion -- References -- Chapter 5: Inflammation -- 5.1 Introduction -- 5.2 Mechanism -- 5.3 PAMPs and DAMPs -- 5.4 TLRs -- 5.4.1 Signalling through MyD88-Dependent Activation by TLRs -- 5.5 RIG-I-Like Receptors -- 5.6 NOD-Like Receptors -- 5.7 Tumour Necrosis Factor -- 5.8 Selectins and Integrins -- 5.9 G Protein-Coupled Receptors -- 5.10 C5a Receptor and Formyl Peptide Receptors -- 5.11 Fc Receptors -- 5.12 Acute Phase Proteins (APPs) -- 5.13 Acute Phase Response -- 5.14 C-Reactive Protein -- 5.15 Acute Inflammation -- 5.16 Chronic Inflammation -- 5.17 Inflammation and Disease -- 5.18 Computational Immunology and Inflammation Biology -- 5.19 Discussion -- References -- Chapter 6: Infection and Immunity -- 6.1 Introduction -- 6.2 Infectious Diseases: A Historical Perspective -- 6.3 Viruses -- 6.3.1 DNA Viruses (Classes I and II) -- 6.3.2 RNA Viruses (Classes III and VI).

6.3.3 Immune System and Response to Viral Infection -- 6.3.4 Regulation of Immune Effector Activity during Virus Infection -- 6.3.5 Evading the Immune Responses -- 6.3.6 Strategies for Vaccination and Computational Immunology -- 6.4 Bacteria -- 6.4.1 Gut Microbiome -- 6.4.2 Immune Response to Bacterial Infection -- 6.4.3 Evading the Immune System -- 6.4.4 Bacterial Infection and Major Associated Problems -- 6.5 Fungi -- 6.5.1 Immune System and Fungal Infection -- 6.5.2 How Fungus Evades the Immune System -- 6.5.3 Fungal Vaccination Strategies -- 6.6 Helminths -- 6.6.1 Effector Immune Mechanisms against Helminths -- 6.6.2 Immune Response Evasion -- 6.6.3 Helminths and Allergic and Autoimmune Diseases -- 6.6.4 Vaccine Development -- 6.7 Protozoa -- 6.7.1 Protozoan Infection and the Immune System -- 6.7.2 Evading the Immune System -- 6.7.3 Immunisation/Vaccination -- 6.8 Arthropod-Borne Diseases -- 6.8.1 Malaria -- 6.8.2 Trypanosomiasis -- 6.8.3 Leishmaniasis -- 6.8.4 Post-Kala-Azar Dermal Leishmaniasis -- 6.8.5 Filariasis -- 6.8.6 Onchocerciasis -- 6.8.7 Dengue -- 6.8.8 Rickettsias and Plague -- 6.8.9 Plague -- 6.8.10 Arboviruses -- 6.8.11 Chikungunya -- 6.8.12 Vector-Borne Diseases in Animals -- 6.9 Prions and Diseases -- 6.10 Understanding Host-Parasite Interaction -- 6.11 Molecular Mimicry -- 6.12 The HIV Virus -- 6.12.1 Infection -- 6.12.2 HIV and Factors That Influence Infection -- 6.12.2.1 Host Factors -- 6.12.2.2 Viral Factors -- 6.12.3 Clinical Features -- 6.12.4 Prophylaxis -- 6.12.5 Detection -- 6.12.6 Disease Management -- 6.12.7 Recent Developments in AIDS Vaccine -- 6.13 Computational Immunology and the Biology of Infection -- 6.14 Discussion -- References -- Chapter 7: Transplantation Immunology -- 7.1 Introduction -- 7.2 Organ Transplantation: A Historical Perspective.

7.3 Histocompatibility and Transplantation Biology from a Historical Perspective.

The first volume describes detailed complexity of the immune system in human and in invertebrates. It also gives an idea of different computational tools and techniques in understanding the complexity of immune systems.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.

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