Staphylococcus : Genetics and Physiology.

Intro -- Contents -- Contributors -- Preface -- Current Books of Interest -- 1. History of Staphylococcus aureus -- Introduction -- Discovery: identification and classification -- Mapping of the S. aureus genome -- Pathogenesis -- Urinary tract infections -- Vaccines and immunity -- Antibiotic efficacy and resistance -- Meetings -- Conclusions -- 2. Clinical Significance in Humans -- Introduction -- Staphylococci: a short description of the species -- Staphylococci: natural commensals of humans -- Staphylococcal disease: clinically important manifestations -- Conclusions -- 3. Staphylococcus: Clinical Significance in Animals -- Introduction -- Staphylococci as veterinary pathogens -- Virulence factors -- Staphylococcus aureus infections in animals -- Staphylococcus intermedius group (SIG) and associated diseases -- Coagulase-negative staphylococci -- Treatment of veterinary staphylococci infections -- Antimicrobial resistance in veterinary staphylococci -- Methicillin-resistant Staphylococcus pseudintermedius -- Conclusions and future trends -- 4. Staphylococcal Variation and Evolution -- Introduction -- The S. aureus genome -- Variation between isolates -- Variation: mechanisms -- Selection -- Other staphylococcal species -- Technology -- Conclusions and future -- 5. Staphylococcal Virulence Factors -- Introduction -- Colonization: teichoic acids and microbial surface components recognizing adhesive matrix molecules (MSCRAAMs) -- Superantigens (SAgs) and exfoliative toxins (ETs): systemic defence against the human immune system -- Cytotoxins: the second line of defence against the human immune system -- Third line of S. aureus defence against the human immune system -- 6. Staphylococcus aureus Metabolism and Physiology -- Introduction -- Cultivation of Staphylococcus aureus -- Staphylococcal growth phases and changes in metabolism.

Staphylococcus aureus metabolism -- Glycolysis -- Pentose phosphate pathway -- Tricarboxylic acid cycle -- Gluconeogenesis -- Amino sugar biosynthesis -- Amino acid synthesis -- Nucleic acid synthesis -- Conclusion -- 7. Physiological Proteomics of Staphylococcus aureus: from the Protein Inventory to Stress Physiology and in vivo Adaptation -- Introduction -- The protein inventory of S. aureus -- S. aureus proteomic signatures: towards an understanding of S. aureus adaptation to the human host during colonization and infection -- Concluding remarks -- 8. Cell Wall Assembly and Physiology -- Introduction -- S. aureus membrane lipids and their synthesis -- S. aureus peptidoglycan structure, synthesis and function -- Cell wall proteins in S. aureus -- Teichoic acids in S. aureus -- Exopolysaccharides in S. aureus -- Cell wall synthesis inhibitors and resistance mechanisms -- Conclusions -- 9. Transition Metal Ion Homeostasis -- Introduction -- Iron -- Manganese -- Zinc -- Nickel and cobalt -- Avoiding excess: mechanisms of defence against toxic metals -- The importance of metal ion homeostasis in the host -- Host iron metabolism -- Host Mn, Cu and Zn metabolism -- Concluding remarks -- 10. Stress Responses in Staphylococcus aureus -- Introduction -- The heat shock response: a general response to protein damage -- The SigB regulon -- Oxidative stress -- DNA damage response -- Osmotic stress -- Cold stress -- The stringent response -- Cell envelope stress -- Concluding remarks -- 11. Molecular Strategies of Staphylococcus aureus for Resisting Antibiotics -- Introduction -- Resistance to antibiotics used in the therapy of S. aureus infection -- Discussion -- 12. Genetic Regulation -- Introduction -- Two-component systems -- The Sar family of DNA-binding proteins -- Metabolite responsive elements -- Alternative σ factors -- Regulatory RNAs.

Conclusions and future trends -- 13. Immune Response to Staphylococcus aureus -- Introduction -- Innate immune response to bacterial infection -- Adaptive immune response to bacterial infection -- Immune regulation -- Why immunity fails: immune evasion and immunodeficiency -- Immunological memory and protective immunity -- Anti-S. aureus vaccines -- Discussion -- Index.

This book brings together respected S. aureus experts from around the world to provide a timely overview of staphylococcal research. Topics covered include: historical background; medical significance in humans and animals; genetic variation; virulence factors; metabolism and physiology; physiological proteomics; cell wall assembly and physiology; transition metal ion homeostasis; molecular strategies of antibiotic resistance; genetic regulation; and immune response. Essential reading for scientists working with staphylococci. This text is an excellent introduction for entry level scientists, as well as those seeking a deeper understanding of this critically important bacterial pathogen.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.