Malaria Parasites : Comparative Genomics, Evolution and Molecular Biology.

Intro -- Contents -- Preface -- Ch 01: The Diversity of Plasmodium and other Haemosporidians: The Intersection of Taxonomy, Phylogenetics and Genomics -- Ch 02: The Apicomplexan Genomic Landscape: The Evolutionary Context of Plasmodium -- Ch 03: Plasmodium Genomics and the Art of Sequencing Malaria Parasite Genomes -- Ch 04: Genome Diversity and Applications in Genetic Studies of the Human Malaria Parasites Plasmodium falciparum and Plasmodium vivax -- Ch 05: Functional Genomics of Plasmodium Parasites -- Ch 06: Plasmodium Experimental Genetic Crosses -- Ch 07: Regulation of Gene Expression -- Ch 08: Invasion of Host Red Blood Cells by Malaria Parasites -- Ch 09: Host Cell Remodelling and Protein Trafficking -- Ch 10: Dissecting Mosquito-Parasite Interactions through Molecular Biology and Biochemistry: Genomic, Proteomic and Glycomic Analyses -- Ch 11: The Malariologist's Molecular Toolbox.

Since the publication of the first two Plasmodium genome sequences in 2002, numerous other parasite genomes have been sequenced. These include the genomes of several more Plasmodium species as well as those of other apicomplexans, including species of Toxoplasma, Cryptosporidium, Babesia, and Eimeria. This wealth of genome sequence data has provided researchers with a powerful new tool, comparative genomics, which has revolutionised research in this area. In this book, expert authors from around the world comprehensively review the current advances in Plasmodium comparative genomics, highlighting the fascinating new insights into parasite evolution and molecular biology that have ensued. Topics include: Plasmodium taxonomy and phylogeny; the apicomplexan genomic landscape; the 'art' of sequencing Plasmodium genomes; diversity of Plasmodium falciparum and Plasmodium vivax genomes; Plasmodium functional genomics; Plasmodium experimental genetic crosses; P. falciparum epigenetic modification and transcriptional regulation; Plasmodium invasion of host red blood cells; protein export and trafficking by malaria parasites; Plasmodium-mosquito vector interactions; and a practical guide to many of the revolutionary new techniques and molecular tools for Plasmodium research. The book is essential reading for every researcher working with malaria parasites and related organisms, from the PhD student to the experienced scientist, and is a recommended text for all parasitologists.

Description based on publisher supplied metadata and other sources.

Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.