Leishmania : Current Biology and Control.

Intro -- Contents -- Contributors -- Current Books of Interest -- Preface -- 1: Modulation of Host Cell miRNA Expression During Leishmania Infection and Emergence of miRNA as a New Therapeutic Molecule -- miRNA-mediated gene regulation in metazoan animals -- miRNA as regulator of cholesterol metabolism in mammals -- Cholesterol regulates pathogenesis of Leishmania donovani -- Leishmania-mediated changes in cholesterol production in mammals -- miRNA expression affected by parasite -- Mechanism of miRNA alteration by Leishmania -- Factors important for host cell miRNA alteration during infection -- miRNA as therapeutic agent -- Future of miRNA as a therapeutic agent against visceral leishmaniasis -- 2: Heat Shock Proteins of Leishmania: Chaperones in the Driver's Seat -- Introduction: heat shock proteins -- Heat shock proteins in Leishmania spp. -- Leishmania and the cell stress -- The pitfalls of analogy-based assumptions -- The chaperone machinery and signal transduction in Leishmania -- Open questions -- Future trends -- Acknowledgements -- 3: Role of Iron in Leishmania-Macrophage Interaction -- Introduction -- Aqueous chemistry and toxicity of iron -- Role of iron in physiology -- Role of iron in the host-parasite interaction -- Special need of iron for Leishmania -- Mammalian iron homeostasis components important for sequestering iron -- Regulation of cellular iron metabolism of mammalian host -- Source of host iron and its acquisition systems in Leishmania -- Summary and future aspects -- 4: Oxidative and Nitrosative Stress Response in Leishmania -- Introduction -- Sources of superoxide and hydrogen peroxide in Leishmania -- Targets of reactive oxygen species in Leishmania -- Defence against reactive oxygen species -- Nitrosative stress in Leishmania -- Generation of reactive nitrogen species.

Targets of reactive nitrogen species (RNS) in Leishmania -- Cellular defences against nitrosative stress in Leishmania -- Conclusion -- Future perspectives -- 5: Cell Death in a Kinetoplastid Parasite, the Leishmania spp. -- Introduction -- Life cycle of Leishmania spp. -- Treatment of leishmaniasis -- Programmed cell death (PCD) -- Programmed cell death in protozoan parasites -- Relevance of studying cell death in Leishmania -- Apoptosis in Leishmania -- Natural cell death during cell cycle -- Induction of cell death by anti-leishmanial drugs -- Oxidative stress induced cell death -- Role of apoptotic mimicry and apoptosis in Leishmania -- Autophagy in Leishmania -- Future trends -- Conclusion -- 6: Elucidating the Strategies of Immune Evasion by Leishmania -- Introduction -- Defying recognition by the host: modulation of Toll-like receptor-mediated signalling -- Deactivation of host signalling: mitogen-activated protein (MAP) kinases and phosphatases -- Disarming the enemy: inhibition of host microbicidal molecules -- Delaying phagosome maturation: buying time for promastigote to amastigote conversion -- Creating a favourable environment: polarization of Th (T-helper cell) response -- Suppression of antigen presentation: escaping cytotoxic T-cell response -- Protection of niche: inhibition of macrophage apoptosis by Leishmania parasites -- Conclusion -- 7: Role of STAT Signalling in Immunity to Leishmaniasis -- Introduction -- STAT1 and leishmaniasis -- STAT2 and leishmaniasis -- STAT3 and leishmaniasis -- STAT4 and leishmaniasis -- STAT6 and leishmaniasis -- Conclusion -- 8: Leishmania Modulates Toll-like Receptor Signalling in Macrophages -- Introduction -- Innate immune receptors on antigen-presenting cell, macrophage -- Toll-like receptors: structure and its agonists -- Interaction of Leishmania and macrophages.

Toll-like receptor signalling upon stimulation with Leishmania surface antigen -- The cumulative effect of Leishmania infection on Toll-like receptors and intra-pattern recognition receptor signalling -- Changes in cytokine synthesis upon synergy within Toll-like receptor stimulations -- Toll-like receptor-Toll-like receptor cross-talk -- Conclusion and future trends -- 9: Role of T-cells in Leishmania Infection -- Introduction -- The widening horizons of T-helper subsets -- CD8+ T-cells response -- T-reg cells as master regulators of immunosuppression -- Evolution of the concept of T-regs in leishmaniasis - a time line -- Contra-regulation -- T-reg biology: lesson learned from leishmaniasis -- T-reg targeting in anti-leishmanial immunotherapy -- Unanswered questions and future perspectives -- Concluding remarks -- 10: Vaccine Biology of Leishmania Infection -- Introduction -- Immunology of Leishmania infection -- Challenges in vaccine development against leishmaniasis -- Rationale of vaccine development against leishmaniasis -- General methods to evaluate vaccine potentials against leishmaniasis -- Antigenic components of Leishmania vaccine -- Vaccine for canine leishmaniasis -- Therapeutic vaccines -- Adjuvants and delivery system -- Summary -- 11: Inhibitors of DNA Topoisomerases as Potential Anti-leishmanial Agents -- Introduction -- Kinetoplastid protozoans express two different kinds of topoisomerases -- Evolutionary aspects of kinetoplastid topoisomerase I and topoisomerase II -- Topoisomerases as therapeutic targets -- Classification of topoisomerase inhibitors -- Topoisomerases as targets for antiparasitic agents -- Conclusion -- 12: Mechanism of Drug Resistance in Visceral Leishmaniasis -- Introduction -- Mechanism of drug resistance -- Conclusion and future trends -- Index.

In this timely book respected Leismania experts distil the important current research highlighting the most insightful discoveries in the field. Topics covered include: modulation of host miRNA; heat shock proteins; Iron in the Leishmania-macrophage interaction; oxidative and nitrosative stress response; cell death; strategies for immune evasion; STAT signalling; parasite modulation of toll-like receptors in macrophages; T cells in Leishmania infection; vaccine biology; inhibitors of Leishmania DNA topoisomerases; and mechanism of drug resistance in visceral Leishmaniasis. An essential text for everyone in the Leishmania community and recommended for researchers working in related fields.

Description based on publisher supplied metadata and other sources.

Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.