Alphaviruses : Current Biology.

Intro -- Contents -- Current Books of Interest -- Contributors -- Preface -- 1: Alphavirus Genome Structure and Replication -- Alphavirus structure and genomic organization -- Alphavirus replication -- 2: Alphavirus Evolution -- Phylogenetic relationships of alphaviruses -- Microscale evolution -- Consequences of alphavirus evolution -- Conclusion -- 3: Laboratory Diagnosis and Detection of Alphaviruses -- Introduction -- Detection and diagnosis -- Conclusions -- 4: The Interaction of Alphaviruses with the Interferon System -- The role of IFN-α/β in control of alphavirus infection -- Type I IFN induction by alphaviruses -- Identification of steps in alphavirus propagation inhibited by host antiviral effectors -- Antagonism of type I IFN responses by the alphaviruses -- 5: Alphaviruses and their Role in Elucidating Antiviral Responses in Mosquitoes -- Introduction -- A historical perspective on antiviral response studies in mosquito cells using alphaviruses -- Control of alphavirus replication by small RNA pathways -- Immune signalling pathways and extracellular mechanisms involved in antiviral defences in mosquitoes -- The role of apoptosis as mosquito antiviral response -- Conclusions -- 6: Animal Models of Alphavirus-induced Inflammatory Disease -- Mouse models of alphavirus disease -- Non-human primate models of alphavirus disease -- Alternative animal models of alphavirus disease -- Conclusions -- 7: Clinical Manifestations of Arthritogenic Alphaviruses -- Introduction -- Clinical spectrum of infections caused by arthritogenic alphaviruses -- Treatment of alphavirus infection -- Conclusion -- 8: Encephalitic Alphaviruses -- Introduction -- Peripheral virus replication and innate immunity in vivo -- CNS pathology and tropism of encephalitic alphaviruses -- CNS immune response to alphaviruses.

9: Application of Alphavirus Vectors for Gene Therapy -- Introduction -- Alphavirus expression vectors -- Alphavirus vectors in gene therapy -- Conclusions -- 10: Case Study: Chikungunya Virus -- Introduction -- Molecular biology of CHIKV -- Epidemiology of CHIKV infections -- Clinical manifestations and pathology of CHIKV infections -- Immune responses against CHIKV infections -- Vaccines and therapy -- Index.

This timely book provides a comprehensive overview of the latest developments in alphavirus research. Written by a team of prominent scientists the main focus is on the pathogenesis and host interactions. Topics covered include: genome structure and replication; viral evolution; laboratory diagnosis and detection; interaction with the interferon system; antiviral responses in mosquitoes; animal models of alphavirus-induced inflammatory disease; clinical manifestations of arthritogenic alphaviruses; encephalitic alphaviruses; the application of alphavirus vectors for gene therapy; and chikungunya virus pathogenesis and the development of control strategies. As the first to focus exclusively on alphaviruses, this book serves as an invaluable resource for researchers and clinicians working with alphaviruses and related viruses. Essential reading.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.