Influenza : Current Research.

Intro -- Contents -- Contributors -- Current Books of Interest -- Preface -- 1: Stem-specific Broadly Neutralizing Antibodies of Influenza Virus Haemagglutinin -- Introduction -- Isolation of stem-specific bnAbs -- Structural basis of stem-specific bnAbs -- Protection mechanism of stem-specific bnAbs -- Novel strategies for eliciting bnAbs in vivo -- Conclusions -- 2: Influenza Virus Replication and Transcription -- Introduction -- The life history of the virus ribonucleoproteins during infection -- The architecture of the virus ribonucleoproteins -- The regulation of transcription and replication -- Role of host factors -- 3: Recent Progress in Understanding Influenza B Virus Haemagglutinin -- Introduction -- The roles of Phe-95 in receptor binding and host tropism -- Structural basis for the divergent evolution -- Structural insights into membrane-fusion mechanism mediated by influenza virus haemagglutinin -- Conclusions -- 4: Structure and Assembly of the Influenza A Virus Ribonucleoprotein Complex -- Introduction -- Overall structure and properties of the RNP -- Structures of the RNP protein components -- NP -- RNP structure -- RNP assembly in vivo -- RNP assembly in vitro -- Nuclear import and export of RNPs -- Specific RNP packaging -- Conclusion -- 5: Host Factors Regulating the Influenza Virus Replication Machinery -- Introduction -- Assembling the replication machinery in the nucleus -- Replication and transcription in the nucleus -- Antagonists of the influenza replication machinery -- Nuclear host factors with an undefined mechanism -- Cellular factors that control host range -- Minor polymerase products -- vRNP export and cytoplasmic transport -- Perspective -- 6: Receptor Specificity in Surveillance of Natural Sequence Evolution of Influenza A Virus Haemagglutinin -- Introduction and significance.

HA-glycan receptor interactions: structural and biochemical aspects of receptor specificity -- Benchmarking measurements of HA-glycan interactions and their relationship to aerosol transmissibility of pandemic viruses -- Residue interaction networks to analyse amino acid changes in the context of natural sequence evolution of HA -- Conclusions and significance -- 7: PB1-F2: A Multifunctional Non-structural Influenza A Virus Protein -- Introduction and context -- Structure -- Expression and localization -- Ecology and evolution -- Multifunctional role in pathogenesis -- Interactions with the immune system -- Implications for treatment and prevention -- Conclusion and future directions -- 8: Avian Influenza H7N9 Virus -- Introduction -- Origin, genesis and epidemiology -- Clinical features and immunology -- Molecular basis of the 'host jump' -- Virulence and drug resistance -- Vaccine development -- Conclusion and perspectives -- Index.

Following on from their highly-acclaimed 2010 book, Drs. Wang and Tao present a new, up-to-date and comprehensive review of current advancements in molecular influenza virology. Topics covered include: stem-specific broadly neutralizing antibodies to the virus hemagglutinin; virus replication and transcription; influenza B virus hemagglutinin; influenza A virus ribonucleoprotein complex; regulation of the virus replication machinery by host factors; evolution of receptor specificity of influenza A virus hemagglutinin: PB1-F2, a multi-functional non-structural influenza A virus protein; and avian influenza H7N9 virus. Highly informative and well referenced, this book is essential reading for all influenza specialists and is recommended reading for all virologists, immunologists, molecular biologists, public health scientists and research scientists in pharmaceutical companies.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.