Myxobacteria : Genomics, Cellular and Molecular Biology.

Intro -- Contents -- Contributors -- Current books of interest -- Preface -- 1: Whence Comes Social Diversity? Ecological and Evolutionary Analysis of the Myxobacteria -- Introduction -- A fundamental unanswered question: why be social? -- Classification and phylogenetic analysis -- Biogeography: patterns and their causes -- Terrestrial biogeography of intraspecific variation -- Socially mediated selection -- 2: Genome Evolution and Content in the Myxobacteria -- Myxobacteria genome sequencing history -- Myxobacteria whole-genome comparisons: genome size -- Myxobacteria whole-genome comparisons: genome organization and conserved synteny -- Myxobacteria whole-genome comparisons: genetic content -- Myxobacteria whole-genome comparisons: signal transduction -- Myxobacteria whole-genome comparisons: the genetic programme for fruiting body formation -- Future of myxobacteria genomics -- 3: Myxococcus xanthus Vegetative and Developmental Cell Heterogeneity -- Introduction -- Phase variation -- Cell clusters -- Fruiting bodies -- Peripheral rods -- Programmed cell death/developmental autolysis -- Concluding remarks -- 4: Cell Cycle Regulation in Myxococcus xanthus During Vegetative Growth and Development: Regulatory Links Between DNA Replication and Cell Division -- Introduction -- Organization of the Myxococcus xanthus chromosome -- Chromosome replication and segregation in Myxococcus xanthus -- Cell division in Myxococcus xanthus -- The cell cycle and DNA synthesis during sporulation -- DNA replication is required for fruiting body formation and myxospore formation -- DNA replication and checkpoint control of development -- Perspectives -- 5: Social Interactions Mediated by Outer Membrane Exchange -- Discovery path for OM exchange -- Cis requirement in cargo proteins for transfer.

Transfer requires cell-cell contact, a solid surface and cell motility -- OM lipids are transferred -- Identification of transfer machinery proteins -- Synthetic CglF peptide restores A-motility -- OM exchange regulates cell behaviours -- Proposed mechanism of OM exchange -- Physiological and ecological perspectives of OM exchange -- 6: Developmental Gene Regulation -- Introduction -- The σ54 regulatory system -- Domain architecture of Myxococcus xanthus EBPs -- EBPs and developmental gene expression -- The early-functioning EBPs form a regulatory cascade -- Inputs and outputs of the EBP regulatory cascade -- The Mrp and FruA modules -- Regulation of C-signal-dependent genes -- Regulation of the dev operon depends on C-signalling and three transcription factors -- A plethora of potential late genes revealed by studying glycerol-induced sporulation -- Evolution of the GRN -- Conclusions -- Questions and future directions -- 7: Abundance and Complexity of Signalling Mechanisms in Myxobacteria -- Introduction -- Two-component systems -- ECF σ factors -- Eukaryotic-like Ser/Thr protein kinases and phosphatases -- Concluding remarks and future perspectives -- 8: Computational Biology: From Observation to Statistical Image Analysis to Modelling and Back to Biology -- Introduction -- General introduction to mathematical and computational modelling -- Biochemical control of reversals in Myxococcus xanthus -- Swarm formation -- Ripple formation -- Fruiting body development -- Conclusions and prospects -- 9: The Mechanism of A-Motility -- Myxococcus uses two distinct motility systems: A- and S-motility -- Characterizing the motility machinery -- The motility mechanism -- Conclusion -- 10: Type IV Pili and Exopolysaccharide-dependent Motility in Myxococcus xanthus -- Introduction -- Early advances: pili and exopolysaccharides in Myxococcus xanthus S-motility.

Current model for S-motility -- T4P is a retractile motor -- EPS as a receptor and trigger for T4P retraction -- Structure of T4P in comparison with T2SS -- Dynamics of the T4P motor -- Regulation of EPS accumulation in Myxococcus xanthus -- Unresolved questions and future perspectives -- 11: Sensory Regulation of Myxococcus xanthus Motility -- Introduction -- The chemotaxis paradigm in Escherichia coli -- The Myxococcus xanthus chemosensory pathways are structurally similar to that of E. coli but the motility systems differ -- Myxococcus xanthus chemosensory systems -- Concluding remarks -- 12: The Biophysics of Myxococcus xanthus Motility -- Introduction -- Biophysics at the bacterial scale -- Biophysical tools for studying motility -- Bacterial motility -- Twitching motility -- Gliding motility -- Multicellular pattern formation -- Index.

In this book, expert myxobiologists describe important recent advances in understanding the behaviour of these bacteria at a molecular and cellular level. The book covers ecology, genomics and cell biology as well as modelling and simulation on topics including motility, development and their associated genetic regulatory networks. Authors provide the most up-to-date overview on myxobacteria and highlight open questions in the active areas of research. The book will serve as an essential reference for everyone working with myxobacteria. Chapters have been written and structured to be accessible to teachers, graduate and advanced undergraduate students new to myxobacteria, as well as experts in other fields including physical and computational sciences.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.