Bacterial Evasion of the Host Immune System.

Intro -- Contents -- Current Books of Interest -- Preface -- 1 Secretion Systems Used by Bacteria to Subvert Host Functions -- Introduction -- Mechanism of protein translocation by bacterial secretion systems -- Gram-positive mechanism of secretion -- Virulence factors in host cell interaction -- Conclusion -- 2 Within-host Envelope Remodelling and its Impact in Bacterial Pathogen Recognition -- Introduction -- Immune evasion strategies based on a 'direct attack' to innate host defences -- The masking strategy: immune evasion based on the interference with host receptors recognizing microbe-associated molecular patterns -- Immune evasion and the alteration of envelope components -- Evasion due to impaired LPS recognition by the TLR4-MD2 complex -- Direct analysis of lipid A produced by pathogens within the host -- The peptidoglycan: a plastic molecule influencing host innate immune responses -- Peptidoglycan structural modifications leading to 'intrinsic' immune evasion -- Modification of the peptidoglycan moiety 'within the host' can affect innate immune defences -- Evasion of the inflammasome defence -- Concluding remarks -- 3 Subversion of Macrophage Functions by Bacterial Protein Toxins and Effectors -- Introduction -- Evasion of phagocytosis by macrophages -- Modulation of cytoplasmic immune signalling pathways -- Interference with autophagy -- Interference with cell death signalling -- Conclusion and future perspective -- 4 Manipulation of Autophagy by Bacterial Pathogens Impacts Host Immunity -- Introduction -- Autophagosome formation, elongation and maturation is a complex process involving conserved host factors -- Cross-talk between autophagy and the innate immune response -- Autophagy cross-talks with adaptive immune responses -- Autophagy regulates cytokine production during bacterial infection.

Intracellular bacteria modulate autophagy in the infected cell -- Autophagy subversion by pathogenic bacteria shapes host immunity -- Concluding remarks -- 5 Inflammasome-dependent Mechanisms Involved in Sensing and Restriction of Bacterial Replication -- Introduction -- Canonical and non-canonical inflammasomes -- Inflammasome activation during bacterial infections -- Concluding remarks -- 6 Molecular Mechanisms Used by Salmonella to Evade the Immune System -- Introduction -- Overview of mechanisms of immune defence -- Evasion of the innate immune system -- Mechanisms to escape adaptive immunity -- Persistence -- Concluding remarks -- 7 Immune-evasion Strategies of Mycobacteria and their Implications for the Protective Immune Response -- Introduction -- Mycobacteria use redundant strategies to inhibit the microbicidal activity of myeloid cells -- Mycobacteria modulate the microenvironment to subvert infected-cell death pathways and recruit permissive macrophages -- Delayed T-cell priming during mycobacterial infections -- The impact of the inflammatory environment in accumulating T cells -- The impact of chronic infection in T-cell function and granuloma formation -- Mycobacterium ulcerans infection: an extreme among mycobacteria -- Conclusion -- Role of Cyclic di-GMP in the Bacterial Virulence and Evasion of the Plant Immunity -- An overview of bacterial plant diseases -- Innate versus adaptive immunity in plants -- Cyclic di-GMP: a relevant secondary messenger in pathogen-host interactions -- Cyclic di-GMP controls the expression of the type III secretion system -- Cyclic di-GMP coordinates exopolysaccharide production -- Conclusions and future perspectives -- Index.

In this volume expert authors critically review the most important current research in this exciting field. Topics include: the seven most important bacterial secretion systems; within-host envelope remodelling; subversion of macrophages; pathogen manipulation of host autophagy; mechanisms involved in sensing and restriction of bacterial replication; mechanisms of evasion by Salmonella; evasion strategies of mycobacteria; and role of Cyclic di-GMP in virulence and evasion of plant immune systems. This text is essential reading for everyone involved in bacterial pathogenesis research and an invaluable reference work for those working in fields as diverse as medicine, biotechnology, agriculture, food and industry. A recommended acquisition for all microbiology laboratories.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.