Contemporary Treatment of Erectile Dysfunction : A Clinical Guide.

Intro -- Dedication -- Foreword -- Preface -- Contents -- Contributors -- 1: Animal Models for the Study of Erectile Function and Dysfunction -- Prostatectomy Models -- Diabetic Models -- Aging Models -- Metabolic Syndrome Model -- Hypertension Model -- High Cholesterol Model -- Arteriogenic ED Model -- Hypoxia Model -- Drug Induced -- Radiation-Induced ED -- Conclusion -- References -- 2: Normal Erectile Physiology -- Anatomical Review -- Gross Structure -- Corpora -- Glans -- Arterial Supply -- Veins -- Peripheral Innervation -- Hemodynamics of Erection -- Flaccid State -- Tumescence and Erection -- Detumescence -- Local Mechanisms of Erection -- Spinal Control of Erection -- Supraspinal Control of Erection -- Paraventricular Nucleus -- Medial Preoptic Area -- Other Supraspinal Centers -- Central Neurotransmission -- Oxytocin -- Dopamine -- Serotonin -- Nitric Oxide -- ACTH and α-MSH -- Other Neurotransmitters -- References -- 3: Psychological Aspects of Erectile Dysfunction -- Introduction -- The Psychological Assessment -- Individual Factors -- Impact of ED on the Man's Sexual Partner -- Psychological Treatments -- Talking to Patients About Sexual Issues -- Psychological Issues in the Post-­Viagra Era -- Some Thoughts on Sexual and Cultural Diversity -- Case Examples -- Case #1: Bob: A Case of Misunderstanding -- Case #2: Jim: An Example of Combination Treatment -- Case #3: Andrew: A Case of Kinky Desire -- Case #4: Stanley: A Case of ED Following Radical Prostatectomy -- Conclusions -- References -- 4: Epidemiology of Erectile Dysfunction and Key Risk Factors -- Background and Overview -- ED Progression and Remission -- ED Findings from the Boston Area Community Health Survey (Fig. 4.2) -- Discussion -- References -- 5: Erectile Dysfunction: Etiology and Risk Factors -- Introduction -- Physiology of Penile Erection and Detumescence.

Classification and Etiologic Factors in Erectile Dysfunction -- Risk Factors for Erectile Dysfunction -- Cardiovascular Disease and ED -- Diabetes and ED -- Hypertension and ED -- ED and Smoking -- Obesity and Sedentary Lifestyle in Men with ED -- ED and Lower Urinary Tract Symptoms -- Hypogonadism and ED -- ED and Depression -- The Role of Lifestyle Modification in Mitigating the Risk of ED -- Conclusions -- References -- 6: Making the Diagnosis of Erectile Dysfunction -- Introduction -- Diagnosis of ED: Basic Diagnostic Tools -- Sexual History -- Questionnaires -- Medical History -- Sexual Function and Aging -- Physical Examination -- Laboratory Tests -- Establishing Cardiovascular Risk -- Low-Risk Category -- Intermediate-Risk Category -- High-Risk Category -- First Consultation for ED: What Are Our Goals? -- Additional Diagnostic Tools -- Nocturnal Penile Tumescence and Rigidity Test -- Pharmacological Erection Test -- Duplex/Doppler Penile Ultrasound -- Dynamic Infusion Cavernosometry and Cavernosography -- Phalloarteriography -- Summary: Working Toward a Diagnostic Algorithm -- References -- 7: Hormonal Evaluation and Therapy of Erectile Dysfunction -- Introduction -- Prevalence of Hypogonadism -- Prevalence of Hypogonadism Among Patients with Sexual Dysfunction -- Definition of Hypogonadism -- Laboratory Evaluation of Hypogonadism -- Role of Testosterone in the Physiology of Erections -- Association Between Testosterone and Sexual Function in Human Studies -- Testosterone Replacement Alone as Therapy for ED -- Testosterone Replacement as Therapy for ED in Combination with PDE5 Inhibitors -- Society Recommendations for Hypogonadism Screening in All ED Patients -- Therapy for Hypogonadism -- Algorithms for Testosterone Replacement in Hypogonadal Men with ED -- Other Hormones and ED -- Luteinizing Hormone (LH) -- Prolactin -- Estradiol.

Thyroid Hormone -- Future Directions -- Conclusions -- References -- 8: Effects of Lifestyle Changes and Testosterone Therapy on Erectile Function -- Introduction -- Physiology of Erectile Function (EF) and Pathophysiology of Erectile Dysfunction (ED) -- Risk Factors Contributing to ED -- Lifestyle Modification and EF -- Diet -- Exercise -- Weight Loss -- Weight Loss with Diet and Exercise -- Weight Loss via Pharmacotherapy -- Weight Loss via Bariatric Surgery -- Weight Loss via T therapy -- Smoking -- Diabetes Control -- Prescription Medications and ED -- Summary -- Recommendations and Future Developments -- References -- 9: Cardiovascular Issues in the Treatment of Erectile Dysfunction -- Introduction -- Risk Factors -- ED and CVD: Examining the Link -- The Patient's Assessment -- Key Points -- Testosterone: Its Replacement and Cardiovascular Safety -- Key Points -- References -- 10: Alternative and Internet Drugs that Affect Sexual Function -- Introduction -- Epidemiology -- Regulation -- Impact on Men's Sexual Health -- Common Alternative Medications Used to Treat ED -- Ginseng -- Horny Goat Weed -- Yohimbine -- Maca Root (Lepidium Meyenii) -- Ginkgo biloba -- Ptychopetalum olacoides (Muira Puama) -- l-Carnitine -- l-Arginine -- l-Citrulline -- Conclusion -- References -- 11: Prescription Medications that Affect Sexual Function -- Physiologic Control of Erection and Male Sexual Function -- Drug-Induced Sexual Dysfunction and Its Mechanisms (Fig. 11.2) -- Antihypertensive Agents -- Psychotropic Medications -- Hormonal Agents -- 5α-Reductase Inhibitors -- HIV Therapy -- Lipid-Lowering Medication -- Miscellaneous -- Immunomodulators -- Toxins and Recreational Drugs -- Medication-Induced Ejaculatory Dysfunction -- Psychotropic Medications -- BPH/LUTS Medications -- Management of Drug-Induced Sexual Dysfunction -- References.

12: Oral Prescription Therapy for Erectile Dysfunction -- Introduction -- Centrally Acting Agents -- Yohimbine -- Mechanism of Action -- Pharmacology and Dosing -- Side Effects -- Efficacy -- Conclusion -- Apomorphine -- Mechanism of Action -- Pharmacology and Dosing -- Side Effects -- Efficacy -- Conclusion -- Trazodone -- Mechanism of Action -- Pharmacology and Dosing -- Side Effects -- Efficacy -- Conclusion -- Peripherally Acting Agents -- Erectile Physiology -- Phosphodiesterase Type 5 Inhibitors (PDE5i) -- Sildenafil -- Vardenafil -- Tadalafil -- Avanafil -- Side Effects -- Efficacy -- Atypical Drugs -- Arginine -- Ginseng -- Horny Goat Weed -- Ginkgo Biloba -- Practical Considerations in Administration and Use of Phosphodiesterase Inhibitors -- Optimal Intake Strategy -- Cardiovascular Considerations -- Nitrates -- References -- 13: Vacuum Therapy for Erectile Dysfunction -- Introduction -- History -- Mechanism and Design -- Clinical Evidence -- VCDs in Diabetes -- VCD in Spinal Cord Injury -- Combination Therapy -- Other Indications for Vacuum Therapy -- Post-prostatectomy Penile Rehabilitation -- Penile Lengthening -- Penile Straightening -- Cons, Complications, and Contraindications -- Conclusions and the Future of Vacuum Therapy -- References -- 14: Self-Injection, Transurethral, and Topical Therapy in Erectile Dysfunction -- Introduction -- PGE1 (Alprostadil) -- Administration -- Side Effects -- Alprostadil Summary Points -- Papaverine -- Administration -- Side Effects -- Papaverine Summary Points -- Phentolamine -- Side Effects -- Intracavernous Injection Combinations -- Bimix (Papaverine, Phentolamine) -- Trimix (PGE1, Papaverine, Phentolamine) -- Quadmix (PGE1, Papaverine, Phentolamine, Atropine) -- ICI Combination Summary Points -- Selection of Injectable Agents -- Contraindications to ICI -- Management of Side Effects.

Contraindications to ICI and Side Effects Summary Points -- Muse® -- Efficacy -- Administration -- Side Effects -- MUSE® Summary Points -- Emerging Trends in ICI -- Intracavernosal Injection Clinic Visit -- Compounding Pharmacy for ICI Medications -- Intracavernous Injections Summary Points -- Topical Agents -- Efficacy -- Topical Agent Summary -- Treatment of Erectile Dysfunction After Radical Prostatectomy -- Post-prostatectomy Penile Rehabilitation Summary Points -- Conclusion -- References -- 15: Penile Prosthesis -- Introduction -- Models of Penile Prosthesis -- Cylinder -- Reservoir -- Pump -- Preoperative Workup -- Operative Procedure -- Approaches -- Complications of IPP -- Infection -- Mechanical Failure -- Revision Surgery with Scarred Corporal Bodies -- SST -- Distal Extrusion -- Reservoir Herniation -- Postoperative Care -- References -- 16: Endovascular Approaches to Penile Arterial Revascularization for Vasculogenic Erectile Dysfunction -- Introduction -- Vasculogenic Erectile Dysfunction -- Pudendal Artery Basic Science -- ZEN Trial -- Pudendal Artery Stent Restenosis -- Pelvic Arterial Imaging Modalities -- Transluminal Balloon Angioplasty for Penile Arterial Revascularization -- References -- 17: The Effect of Radical Prostatectomy on Sexual Function -- Prevalence of ED After RP -- Review of Literature -- Discrepancies -- Open Versus Laparoscopic Versus Robot-Assisted -- ED Outcomes After RP -- Definition -- Data Acquisition -- Patient Population Studies -- Pathophysiology of ED After RP -- Neurogenic Mechanisms -- Smooth Muscle Damage -- Cavernosal Oxygenation -- Venous Leak -- Non-ED Sexual Dysfunctions After RP -- Sexual Incontinence -- Climacturia -- Arousal Incontinence -- Orgasmic Pain and Other Changes in Orgasm -- References -- 18: The Effect of Radiation on Erectile Function.

Assessing Erectile Function Outcomes After Radiation.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.