Bioreactors : Design, Operation and Novel Applications.

Intro -- Title Page -- Copyright -- Table of Contents -- Preface -- List of Contributors -- Chapter 1: Challenges for Bioreactor Design and Operation -- 1.1 Introduction -- 1.2 Biotechnology Milestones with Implications on Bioreactor Design -- 1.3 General Features of Bioreactor Design -- 1.4 Recent Trends in Designing and Operating Bioreactors -- 1.5 The Systems Biology Approach -- 1.6 Using Conceptual Design Methodology -- 1.7 An Outlook on Challenges for Bioreactor Design and Operation -- References -- Chapter 2: Design and Operation of Microbioreactor Systems for Screening and Process Development -- 2.1 Introduction -- 2.2 Key Engineering Parameters and Properties in Microbioreactor Design and Operation -- 2.3 Design of Novel Stirred and Bubble Aerated Microbioreactors -- 2.4 Robotics for Microbioreactors -- 2.5 Fed-Batch and Continuous Operation of Microbioreactors -- 2.6 Monitoring and Control of Microbioreactors -- 2.7 Conclusion -- References -- Chapter 3: Bioreactors on a Chip -- 3.1 Introduction -- 3.2 Advantages of Microsystems -- 3.3 Scaling Down the Bioreactor to the Microfluidic Format -- 3.4 Microfabrication Methods for Bioreactors-On-A-Chip -- 3.5 Fabrication Materials -- 3.6 Integrated Sensors for Key Bioreactor Parameters -- 3.7 Model Organisms Applied to BRoCs -- 3.8 Applications of Microfluidic Bioreactor Chip -- 3.9 Scale Up -- 3.10 Conclusion -- References -- Chapter 4: Scalable Manufacture for Cell Therapy Needs -- 4.1 Introduction -- 4.2 Requirements for Cell Therapy -- 4.3 Stem Cell Types and Products -- 4.4 Paradigms in Cell Therapy Manufacture -- 4.5 Cell Therapy Manufacturing Platforms -- 4.6 Microcarriers and Stirred-Tank Bioreactors -- 4.7 Future Trends for Microcarrier Culture -- 4.8 Preservation of Cell Therapy Products -- 4.9 Conclusions -- References -- Chapter 5: Artificial Liver Bioreactor Design.

5.1 Need for Innovative Liver Therapies -- 5.2 Requirements to Liver Support Systems -- 5.3 Bioreactor Technologies Used in Clinical Trials -- 5.4 Optimization of Bioartificial Liver Bioreactor Designs -- 5.5 Improvement of Cell Biology in Bioartificial Livers -- 5.6 Bioreactors Enabling Cell Production for Transplantation -- 5.7 Cell Sources for Bioartificial Liver Bioreactors -- 5.8 Outlook -- References -- Chapter 6: Bioreactors for Expansion of Pluripotent Stem Cells and Their Differentiation to Cardiac Cells -- 6.1 Introduction -- 6.2 Culture Technologies for Pluripotent Stem Cell Expansion -- 6.3 3D Suspension Culture -- 6.4 Autologous Versus Allogeneic Cell Therapies: Practical and Economic Considerations for hPSC Processing -- 6.5 Upscaling hPSC Cardiomyogenic Differentiation in Bioreactors -- 6.6 Conclusion -- References -- Chapter 7: Culturing Entrapped Stem Cells in Continuous Bioreactors -- 7.1 Introduction -- 7.2 Materials Used in Stem Cell Entrapment -- 7.3 Synthetic Materials -- 7.4 Natural Materials -- 7.5 Manufacturing and Regulatory Constraints -- 7.6 Mass Transfer in the Entrapment Material -- 7.7 Continuous Bioreactors for Entrapped Stem Cell Culture -- 7.8 Future Perspectives -- References -- Chapter 8: Coping with Physiological Stress During Recombinant Protein Production by Bioreactor Design and Operation -- 8.1 Major Physiological Stress Factors in Recombinant Protein Production Processes -- 8.2 Monitoring Physiological Stress and Metabolic Load as a Tool for Bioprocess Design and Optimization -- 8.3 Design and Operation Strategies to Minimize/Overcome Problems Associated with Physiological Stress and Metabolic Load -- 8.4 Bioreactor Design Considerations to Minimize Shear Stress -- Acknowledgments -- References -- Chapter 9: Design, Applications, and Development of Single-Use Bioreactors -- 9.1 Introduction.

9.2 Design Challenges of Single-Use Bioreactors -- 9.3 Cell Culture Application -- 9.4 Microbial Application of Single-Use Bioreactors -- 9.5 Outlook -- References -- Chapter 10: Computational Fluid Dynamics for Bioreactor Design -- 10.1 Introduction -- 10.2 Multiphase Flows -- 10.3 Turbulent Flow -- 10.4 CFD Simulations -- 10.5 Case Studies for Application of CFD in Modeling of Bioreactors -- Summary -- References -- Chapter 11: Scale-Up and Scale-Down Methodologies for Bioreactors -- 11.1 Introduction -- 11.2 Bioprocess Scale-Down Approaches -- 11.3 Characterization of the Large Scale -- 11.4 Computational Methods to Describe the Large Scale -- 11.5 Scale-Down Experiments and Physiological Responses -- 11.6 Outlook -- References -- Chapter 12: Integration of Bioreactors with Downstream Steps -- 12.1 Introduction -- 12.2 Improvements in Cell-Culture -- 12.3 Interactions with Centrifugation Steps -- 12.4 Interactions with Filtration Steps -- 12.5 Interactions with Chromatographic Steps -- 12.6 Integrated Processes -- 12.7 Integrated Models -- 12.8 Conclusions -- References -- Chapter 13: Multivariate Modeling for Bioreactor Monitoring and Control -- 13.1 Introduction -- 13.2 Analytical Measurement Methods for Bioreactor Monitoring -- 13.3 Multivariate Modeling Approaches -- 13.4 Case Studies -- 13.5 Conclusions -- Acknowledgments -- References -- Chapter 14: Soft Sensor Design for Bioreactor Monitoring and Control -- 14.1 Introduction -- 14.2 The Process Analytical Technology Perspective on Soft Sensors -- 14.3 Conceptual Design of Soft Sensors for Bioreactors -- 14.4 "Hardware Sensor" Alternatives -- 14.5 The Modeling Part of Soft Sensors -- 14.6 Strategy for Using Soft Sensors -- 14.7 Applications of Soft Sensors in Bioreactors -- 14.8 Concluding Remarks and Outlook -- References.

Chapter 15: Design-of-Experiments for Development and Optimization of Bioreactor Media -- 15.1 Introduction -- 15.2 Fundamentals of Design-of-Experiments Methodology -- 15.3 Optimization of Culture Media by Design-of-Experiments -- 15.4 Conclusions and Outlook -- References -- Chapter 16: Operator Training Simulators for Bioreactors -- 16.1 Introduction -- 16.2 Simulators in the Process Industry -- 16.3 Training Simulators -- 16.4 Requirements on Training Simulators -- 16.5 Architecture of Training Simulators -- 16.6 Tools and Development Strategies -- 16.7 Process Models and Simulation Technology -- 16.8 Training Simulator Examples -- 16.9 Concluding Remarks -- References -- Index -- End User License Agreement.

Description based on publisher supplied metadata and other sources.

Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.