Lashley's Essentials of Clinical Genetics in Nursing Practice.

Cover -- Title -- Copyright -- Contents -- Contributors -- Editor's Note -- Preface -- Reference -- Share Lashley's Essentials of Clinicals Genetics in Nursing Practice: Second Edition -- Part I: The Basics -- Chapter 1: Genomics in Health Care -- Human Genome Project -- Increasing Genetic Literacy -- Nursing Roles in a Genomic Era -- Summary -- Key Points -- References -- Bibliography -- Chapter 2: Basic Concepts in Molecular Biology -- Chromosomes -- Cell Division -- Chromosomes and Inheritance -- Genes and DNA -- Gene Expression -- The Genetic Code -- Gene Action and Expression -- Mutations -- Molecular Techniques and Tools for Detection and Diagnosis of Genetic Diseases -- Key Points -- References -- Bibliography -- Chapter 3: Human Diversity and Variation -- We are Not All Genetically Identical -- Genetic Individuality -- Variations and Polymorphisms in Proteins -- Variations and Polymorphisms in DNA -- Maintenance of Variation and Polymorphism in Populations -- Other Examples of Human Genetic Variation -- Key Points -- References -- Bibliography -- Chapter 4: Inheritance Patterns in Human Phenotypes and Types of Genetic Disorders -- Inheritance Patterns of Human Phenotypes -- Nontraditional Inheritance -- Single Gene Inherited Biochemical Disorders -- Chromosomal Abnormalities -- Factors in Numerical Chromosome Errors -- Multifactorial Disorders -- Environmental Disorders -- Factors Affecting the Expression of the Phenotype -- Summary -- Questions for Discussion -- References -- Bibliography -- Chapter 5: Prevention, Genetic Testing, and Treatment of Genetic Disease -- Prevention -- Genetic and Genomic Testing -- Therapeutic Strategies Employed in Genetic Disorders -- Key Points -- References -- Bibliography -- Part II: The Integration of Genetics Into Nursing Curricula -- Chapter 6: The Application of Genomics to Pharmacology.

Common Gene Mutations and Variations Affecting Drug Metabolism -- Less Common Single Gene Disorders with Pharmacogenetic Implications -- Ethical, Legal, and Social Issues Related to Pharmacogenomics -- Summary -- Key Points and Questions for Discussion -- Bibliography -- Resources -- Chapter 7: Assessing Patients With a Genetic "Eye": Family History and Physical Assessment -- Family History -- Pedigrees -- Developmental and Physical Assessment -- Suspecting a Genetic Component and Referral to a Geneticist -- Key Points -- Reference -- Bibliography -- Chapter 8: Maternal-Child Nursing: Obstetrics -- Preconception or Prepregnancy Counseling -- Pregnancy -- The Vulnerable Fetus and Teratogenesis -- Prenatal Detection and Diagnosis -- Assisted Reproductive Techniques -- Screening Gamete Donors -- Newborn Screening -- Conclusions -- Social and Ethical Issues Associated with Screening -- The Future -- Key Points -- Bibliography -- Chapter 9: Maternal-Child Nursing: Pediatrics -- Birth Defects -- Chromosome Disorders -- Inborn Errors of Metabolism -- Selected Genetic Disorders Commonly Seen in Childhood -- Hemoglobin and Its Inherited Variants -- Key Points -- Bibliography -- Chapter 10: Adult Health and Illness and Medical-Surgical Nursing -- Single Gene Inherited Biochemical Disorders Typically Manifesting in Adulthood -- Common/Complex Diseases of Adulthood -- Issues in Adult Health: Genetic Screening and Genetic Testing -- Ecogenetics and Public Health Genomics -- Problems in Associating Effects with Environmental Agents -- Hazardous Exposures in the Environment and Workplace -- Testing, Surveillance, and Genetic Monitoring -- Workplace Screening and Testing -- Surveillance -- Key Points -- References -- Bibliography -- Chapter 11: The Genetic Basis of Cancer -- Genomic Mechanisms in Cancer: An Overview.

Genomic Mutations that Disrupt Cell Differentiation and Function in Cancer -- Genomics of Childhood Cancers -- Leukemias -- Acute Myelogenous Leukemia (AML) -- Brain Tumors -- Neuroblastoma (Chromosomal Gene Fusions) -- Wilms Tumor -- Rhabdomyosarcoma -- Ewing Sarcoma -- Osteosarcoma -- Genomic Mechanisms in Adult Cancers -- Hereditary Cancer Syndromes in Adults -- Epigenome Biochemical Modifications in Cancer Etiology -- Summary -- References -- Bibliography -- Chapter 12: Genetic Elements of Behavioral Disorders -- Genetics and Mental Health -- Schizophrenia -- Mood Disorders -- Behavior and Genetics -- Alcoholism, Smoking, and Addiction -- Nurses and Risk Reduction -- Summary -- Key Points -- References -- Bibliography -- Chapter 13: Ethical and Policy Issues in Clinical Genetics and Genomics -- The History of Eugenics -- Informed Consent -- Issues of Privacy, Confidentiality, and Disclosure -- Ownership and Future Use of Samples Taken for Testing/Screening -- Genetic Discrimination -- Direct-to-Consumer Genome Testing and Genome Test Regulation -- Genetic Testing in Minors -- Incidental Findings -- Summary -- References -- Bibliography -- Appendix A: Resources for Professionals -- Appendix B: Websites Providing Information, Products, and Services for Genetic Conditions -- Groups Providing Genetic Support Group Information -- Groups Providing Support Information on Specific Genetic Disorders -- Glossary -- Index.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.