Neuroendocrinology of Stress.

Intro -- Title Page -- Copyright -- Table of Contents -- List of Contributors -- Series Preface -- Preface -- About the Companion Website -- Chapter 1: Methods and Approaches to Understand Stress Processing Circuitry -- 1.1 Introduction -- 1.2 Assessment of stress activation -- 1.3 Stress circuit connectivity -- 1.4 Lesion, inactivation and stimulation approaches -- 1.5 Perspectives -- Cited references -- Chapter 2: Brain Monoaminergic Systems in Stress Neuroendocrinology -- 2.1 Introduction -- 2.2 Serotonergic systems and HPA axis function -- 2.3 Catecholaminergic systems and HPA axis function -- 2.4 Histaminergic systems and HPA axis function -- 2.5 Organic cation transporters and monoaminergic control of the HPA axis -- 2.6 Conclusions/implications -- Cited references -- Chapter 3: The Synaptic Physiology of the Central Nervous System Response to Stress -- 3.1 The hypothalamic-pituitary-adrenal axis -- 3.2 Corticosteroid signalling: Mineralocorticoid and glucocorticoid receptors -- 3.3 Electrophysiology of hypothalamic circuits controlling the HPA axis -- 3.4 Electrophysiological responses of hippocampal cells to stress -- 3.5 Electrophysiological responses of amygdala cells to stress -- 3.6 Perspective -- Acknowledgements -- Cited references -- Chapter 4: Illuminating the (Electro)physiology of Anterior Pituitary Corticotrophs -- 4.1 Introduction: Stress and the pivotal role of the anterior pituitary corticotroph -- 4.2 How to identify a living corticotroph? -- 4.3 Exploiting labelled corticotrophs to explore ion channels and excitability -- 4.4 Modelling corticotroph excitability -- 4.5 Discussion -- 4.6 Perspectives -- Cited references -- Chapter 5: Stress and Sympathoadrenomedullary Mechanisms -- 5.1 Stress and research on stress -- 5.2 Stress-triggered adrenomedullary catecholamine release.

5.3 Stress-triggered induction of catecholamine biosynthesis -- 5.4 Transcriptional pathways associated with acute and repeated stress -- 5.5 Effects of stress on adrenomedullary peptide gene expression -- 5.6 Microarray analysis of stress-triggered changes in gene expression in adrenal medulla -- 5.7 Neuronal, hormonal or humoral inputs for regulation of catecholamine biosynthesis and release -- 5.8 Prospective -- Acknowledgements -- Cited references -- Chapter 6: Neuroendocrine Mechanisms of Stress Regulation in Humans -- 6.1 A short account of stress research concepts -- 6.2 Systems associated with stress -- 6.3 Measures of stress -- 6.4 The interaction of the stress response systems and the relevance for (psycho)pathology -- Summary and outlook -- Cited references -- Chapter 7: Studying Chronic Stress in Animals: Purposes, Models and Consequences -- 7.1 Introduction -- 7.2 Adaptation to stressors repeated daily -- 7.3 Overall neuroendocrine consequences of daily exposure to stressors -- 7.4 Conclusions and perspectives -- Cited references -- Chapter 8: Modelling Stress-Related Mood Disorders in Animals -- 8.1 Stress-related mood disorders -- 8.2 Animal models for stress-related mood disorders -- 8.3 Tests for assessing symptoms of depression in rodents -- 8.4 Mechanisms of mood disorders: Contributions from animal models -- 8.5 Perspectives -- Cited references -- Chapter 9: Glucocorticoid Involvement in Drug Abuse and Addiction -- 9.1 Drug addiction -- 9.2 Stress, motivation and addiction -- 9.3 Glucocorticoids and addiction -- 9.4 Cocaine: Mechanism of action -- 9.5 The rat intravenous (i.v.) drug self-administration approach for the study of drug abuse/addiction -- 9.6 Preclinical assessment of the involvement of glucocorticoids in addiction -- 9.7 Glucocorticoid-dependent neuroplasticity that contributes to addiction.

9.8 Effects of cocaine self-administration on glucocorticoids -- 9.9 Similarities and differences in glucocorticoid contributions across classes of illicit drugs -- 9.10 Summary -- Cited references -- Chapter 10: The Hypothalamic-Pituitary-Adrenal Axis: Circadian Dysregulation and Obesity -- 10.1 Historical introduction -- 10.2 The daily cortisol/corticosterone rise -- 10.3 Circadian rhythms in the hypothalamic-pituitary-adrenal axis -- 10.4 The food-anticipatory rise in corticosterone secretion -- 10.5 Clock gene rhythms within the adrenal gland -- 10.6 Entrainment of peripheral clocks by glucocorticoids -- 10.7 Glucocorticoids and the metabolic syndrome -- 10.8 Shift work and adrenal corticoids -- 10.9 Conclusions -- Acknowledgements -- Cited references -- Chapter 11: Using Rodent Models to Explore the Role of 11β-Hydroxysteroid Dehydrogenase 2 (11β-HSD2) in Prenatal Programming by Glucocorticoids -- 11.1 Developmental programming -- 11.2 11β-HSD2: The epicentre of developmental programming? -- 11.3 How might deletion of 11β-HSD2 programme affective behaviour? -- 11.4 Don't forget the placenta! -- 11.5 Refining the model: A brain-specific knock-out of 11β-HSD2 during development -- 11.6 Perspectives -- Cited references -- Chapter 12: Early-Life Stress: Rodent Models, Lessons and Challenges -- 12.1 Why study early-life stress? -- 12.2 Vulnerability of the developing brain -- 12.3 The mother is key: ELS models and manipulation of maternal input -- 12.4 Validity and reliability of ELS models -- 12.5 Consequences of chronic early-life stress -- 12.6 Perspectives -- Cited references -- Further recommended reading Reviews of animal models of ELS -- Key primary research papers using rodent ELS models -- Additional related background and conceptual material -- Appendix. Protocol for limited nesting model of ELS.

Chapter 13: Mothering Influences on Offspring Stress Response Mechanisms -- 13.1 Introduction -- 13.2 Maternal behaviour and care of the offspring -- 13.3 Impact of altered maternal care on infant stress responses: General considerations -- 13.4 Development of stress responsiveness in the offspring -- 13.5 Experimental preclinical models used for the study of maternal care and stress responses in offspring -- 13.6 Consequences of altered maternal care on offspring stress responses and behaviour -- 13.7 Potential mediating mechanisms -- 13.8 Conclusions -- Cited references -- Further recommended reading -- Chapter 14: Translational Research in Stress Neuroendocrinology: 11β-Hydroxysteroid Dehydrogenase 1 (11β-HSD1), A Case Study -- 14.1 Introduction -- 14.2 Small molecule drug discovery and development -- 14.3 11β-HSD1 inhibitors -- Cited references -- Glossary -- Index -- End User License Agreement.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.