Statistical Methods in Genetic Epidemiology. (Record no. 66677)
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| fixed length control field | 08250nam a22004813i 4500 |
| 001 - CONTROL NUMBER | |
| control field | EBC3053710 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MiAaPQ |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20240729124440.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS | |
| fixed length control field | m o d | |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | cr cnu|||||||| |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 240724s2004 xx o ||||0 eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9780199748051 |
| Qualifying information | (electronic bk.) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| Canceled/invalid ISBN | 9780195159394 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (MiAaPQ)EBC3053710 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (Au-PeEL)EBL3053710 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (CaPaEBR)ebr10375313 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (CaONFJC)MIL84530 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (OCoLC)76953042 |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | MiAaPQ |
| Language of cataloging | eng |
| Description conventions | rda |
| -- | pn |
| Transcribing agency | MiAaPQ |
| Modifying agency | MiAaPQ |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER | |
| Classification number | RB155.T468 2004 |
| 082 0# - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 616.042 |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Thomas, Duncan C. |
| 245 10 - TITLE STATEMENT | |
| Title | Statistical Methods in Genetic Epidemiology. |
| 250 ## - EDITION STATEMENT | |
| Edition statement | 1st ed. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | Cary : |
| Name of producer, publisher, distributor, manufacturer | Oxford University Press, Incorporated, |
| Date of production, publication, distribution, manufacture, or copyright notice | 2004. |
| 264 #4 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | ©2004. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 1 online resource (458 pages) |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Content type code | txt |
| Source | rdacontent |
| 337 ## - MEDIA TYPE | |
| Media type term | computer |
| Media type code | c |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | online resource |
| Carrier type code | cr |
| Source | rdacarrier |
| 505 0# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Intro -- Contents -- SUMMARY OF COMMONLY USED NOTATION -- 1. OVERVIEW OF GENETIC EPIDEMIOLOGY -- The Process of Genetic Epidemiology -- Descriptive Epidemiology and Hypothesis Generation -- Familial Aggregation -- Segregation Analysis -- Linkage Analysis -- Fine Mapping and Cloning -- Candidate Gene Association Studies -- Characterizing the Effects of Cloned Genes -- Conclusions -- 2. BASIC CONCEPTS OF MOLECULAR GENETICS -- Chromosomes -- Cell Division -- Cell Cycle -- Mitosis -- Meiosis -- Genetic Recombination -- Meiotic Recombination -- Mitotic Recombination -- DNA -- Gene Expression -- Transcription -- RNA Processing -- Translation -- Post-Translational Modification -- DNA Polymorphism -- Conclusions -- 3. PRINCIPLES OF MENDELIAN INHERITANCE -- Basic Concepts -- Mendelian Inheritance at a Single Locus -- Classical Autosomal Dominant Inheritance -- Classical Autosomal Recessive Inheritance -- Classical X-Linked Inheritance -- Multiallelic Loci -- Mendelian Inheritance at Two Loci -- Conclusions -- 4. BASIC EPIDEMIOLOGIC AND STATISTICAL PRINCIPLES -- Basic Probability Theory -- Basic Epidemiologic Principles -- Study Designs -- Measures of Disease Frequency and Association -- Interpretation of Epidemiologic Associations -- Maximum Likelihood -- Generalized Estimating Equations -- Markov Chain Monte Carlo Methods -- Randomization Procedures -- Conclusions -- 5. FAMILIAL AGGREGATION -- Genetic Relationships and Gene Identity -- Formal Derivation of & -- #966 -- and & -- #916 -- -- Familial Correlations of Continuous Phenotypes -- Familial Risk of Disease -- The Concept of Familial Risk -- Design Principles -- Analytical Approaches -- Other Designs -- Randomization Tests of Familial Clustering -- Twin Studies -- Adoption Studies -- Approaches to Dependent Data -- Genetic Models -- Regressive Models -- Frailty Models. |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Generalized Estimating Equations -- Conclusions -- 6. SEGREGATION ANALYSIS -- Design Issues -- Ascertainment of Families -- Sequential Sampling -- Classical Methods for Sibships -- Ascertainment Correction -- Likelihood Methods for Pedigree Analysis -- General Model -- Polygenic and Mixed Models -- Penetrance Models -- The Elston-Stewart Peeling Algorithm -- Hypothesis Testing -- Alternative Methods -- Gibbs Sampling -- Generalized Estimating Equations -- Applications to Breast Cancer -- Conclusions -- 7. LINKAGE ANALYSIS -- Recombination and Map Functions -- Direct Counting Methods -- Relative Pair Methods -- Identity by State and by Descent -- Affected Sib Pair Methods -- Affected Relative Pair Methods -- Sib Pair Methods for Quantitative Traits -- Generalized Estimating Equation Methods -- Lod Score Methods -- Two-Point Linkage -- Joint Segregation and Linkage Analysis and the Mod Score -- Multipoint Linkage and Ordering Loci -- Genome-Wide Scans -- Genetic Heterogeneity -- Gibbs Sampling Methods -- Design Issues -- Power and Sample Size -- Selection Bias and Misspecification -- Fine Mapping and Cloning of BRCA1 -- Conclusions -- 8. PRINCIPLES OF POPULATION GENETICS -- Distribution of Genes at a Single Locus -- Hardy-Weinberg Equilibrium in Large Populations -- Genetic Drift in Finite Populations -- Effects of Mutation and Selection -- Distribution of Genes at Two Loci -- Origins of Linkage Disequilibrium -- Decay of Linkage Disequilibrium -- Estimation of Linkage Disequilibrium -- Evolution of Haplotypes -- Ancestral Inference -- Coalescent Trees -- Ancestral Recombination Graphs -- Conclusions -- 9. TESTING CANDIDATE GENE ASSOCIATIONS -- Distributions of Genes in Affected and Unaffected Individuals -- Homogeneous Populations -- Ethnically Stratified Populations -- Families -- Design Options for Association Studies -- Cohort Study Designs. |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Case-Control Designs -- Parental Controls and the Transmission/Disequilibrium Test -- Family-Based Association Tests -- Quantitative Traits -- Conclusions -- 10. LINKAGE DISEQUILIBRIUM MAPPING -- Recently Admixed Populations -- Isolated Populations -- Empiric Methods for Estimating the Location of a Disease Gene or Mutation -- Haplotype Sharing Methods -- Parametric Methods Based on the Coalescent -- How Much Linkage Disequilibrium Is There in the Human Genome? -- Haplotype Block Structure -- Conclusions -- 11. GENE CHARACTERIZATION -- Estimation of Genetic Risks -- Cohort and Case-Control Designs Using Unrelated Subjects -- Familial Cohort Study Designs -- Multistage Sampling and Countermatching -- Relative Efficiency of the Alternative Designs -- Gene-Environment and Gene-Gene Interactions -- Case-Control Designs -- Case-Only Studies -- Case-Parent Trios -- Gene-Environment Interactions for Breast Cancer -- Relative Efficiency of Alternative Designs for Interaction Effects -- Estimation of Gene Frequencies and Carrier Probabilities -- Searching for Additional Genes -- Conclusions -- 12. TYING IT ALL TOGETHER: THE GENETIC EPIDEMIOLOGY OF COLORECTAL CANCER -- History, Descriptive Epidemiology, and Familiality -- Mechanistic Hypotheses -- Models of Carcinogenesis -- Cancer Genes -- Genomic Instability -- Familial Cancer Syndromes -- Familial Adenomatous Polyposis -- Hereditary Nonpolyposis Colorectal Cancer -- Sporadic Cancers -- Genetic Alterations in Colorectal Cancer -- Pathways: Suppressor and Mutator -- Metabolic Pathways -- The Relationship Between Polyps and Colorectal Cancer -- Discovery of Novel Colorectal Cancer Genes -- Implications for Clinical Management -- The Future -- Genome-Wide Scans for Association and Interactions -- Gene Expression Assays -- DNA Methylation and Loss of Imprinting -- Conclusions -- GLOSSARY -- A -- B -- C -- D -- E. |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | F -- G -- H -- I -- K -- L -- M -- N -- O -- P -- Q -- R -- S -- T -- V -- W -- X -- REFERENCES -- INDEX -- A -- B -- C -- D -- E -- F -- G -- H -- I -- J -- K -- L -- M -- N -- O -- P -- Q -- R -- S -- T -- U -- V -- W -- X. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | This balanced and well-integrated text gives a lucid overview of the entire process of genetic epidemiology, from familial aggregation through segregation, likage, and association studies. It is illustrated throughout with examples from the literature on cancer genetics. Statistical concepts are developed in depth, but with a focus on applications. Introductory chapters on molecular biology, Mendelian genetics, epidemiology, statistics, and population genetics are included. Oriented to graduate students in biostatistics, epidemiology, and human genetics, the book will also be a useful reference for researchers. It gives equal emphasis to study designs and data analysis. |
| 588 ## - SOURCE OF DESCRIPTION NOTE | |
| Source of description note | Description based on publisher supplied metadata and other sources. |
| 590 ## - LOCAL NOTE (RLIN) | |
| Local note | Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Genetic epidemiology -- Statistical methods. |
| 655 #4 - INDEX TERM--GENRE/FORM | |
| Genre/form data or focus term | Electronic books. |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Relationship information | Print version: |
| Main entry heading | Thomas, Duncan C. |
| Title | Statistical Methods in Genetic Epidemiology |
| Place, publisher, and date of publication | Cary : Oxford University Press, Incorporated,c2004 |
| International Standard Book Number | 9780195159394 |
| 797 2# - LOCAL ADDED ENTRY--CORPORATE NAME (RLIN) | |
| Corporate name or jurisdiction name as entry element | ProQuest (Firm) |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://ebookcentral.proquest.com/lib/orpp/detail.action?docID=3053710">https://ebookcentral.proquest.com/lib/orpp/detail.action?docID=3053710</a> |
| Public note | Click to View |
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