Telomeres : (Record no. 59768)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 07770nam a22004693i 4500 |
| 001 - CONTROL NUMBER | |
| control field | EBC3018589 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MiAaPQ |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20240729124104.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS | |
| fixed length control field | m o d | |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | cr cnu|||||||| |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 240724s2009 xx o ||||0 eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9781608767205 |
| Qualifying information | (electronic bk.) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| Canceled/invalid ISBN | 9781606923504 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (MiAaPQ)EBC3018589 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (Au-PeEL)EBL3018589 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (CaPaEBR)ebr10660450 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (OCoLC)923659016 |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | MiAaPQ |
| Language of cataloging | eng |
| Description conventions | rda |
| -- | pn |
| Transcribing agency | MiAaPQ |
| Modifying agency | MiAaPQ |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER | |
| Classification number | QH600.3 -- .T456 2009eb |
| 082 0# - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 572.8/7 |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Mancini, Leonardo. |
| 245 10 - TITLE STATEMENT | |
| Title | Telomeres : |
| Remainder of title | Function, Shortening and Lengthening. |
| 250 ## - EDITION STATEMENT | |
| Edition statement | 1st ed. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | New York : |
| Name of producer, publisher, distributor, manufacturer | Nova Science Publishers, Incorporated, |
| Date of production, publication, distribution, manufacture, or copyright notice | 2009. |
| 264 #4 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | ©2009. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 1 online resource (498 pages) |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Content type code | txt |
| Source | rdacontent |
| 337 ## - MEDIA TYPE | |
| Media type term | computer |
| Media type code | c |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | online resource |
| Carrier type code | cr |
| Source | rdacarrier |
| 505 0# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Intro -- Telomeres: Function, Shortening and Lengthening -- Contents -- Preface -- Telomere Dynamics and Biology in Human Progeroid Syndromes -- Abstract -- 1. Introduction -- 2. Telomere Structure and Biology -- 3. Telomeres in Replicative Senescence and Whole Body Ageing -- 4. Human Progeroid Syndromes -- 5. Progeroid Syndromes Not Associated with Telomere Dysfunction -- Discussion -- Conclusion -- References -- The Role of Telomere-Telomerase System in Age-Related Fitness Decline, a Tameable Process -- Abstract -- Behind the Scenes: Introduction -- The Protagonist: Telomere-Telomerase System -- The Other Protagonist: Programmed Cell Death -- The Main Scene: Cell Turnover -- Two Wrong Performances: Dyskeratosis Congenita and Werner Syndrome -- The Main Action: Aging in Man -- A Badly Interpreted Cue: Telomere-Telomerase System as Oncogenic Factor -- An Equivocal Cue: The Confusion between Age-Related Fitness Decline in the Wild and Mortality Increase in Laboratory Conditions -- A Surprising Cue: Animals with Negligible Senescence -- A Poorly Understood Cue: Aging as Distinct Entity -- Ancient and Current Scenery: Toward a Socio-Medical Nightmare -- A Possible Alternative Scenery: Toward the Taming of Senescence -- The Need of a New Dramaturgy: Conclusion -- Acknowledgment -- References -- Cytogenetic Evaluation of Telomere Dysfunction: Chromosomal Aberrations Involving Telomeres and Interstitial Telomeric Sequences -- Abstract -- 1. Introduction -- 2. Cytogenetic Evaluation of Telomere Dysfunction -- Conclusion -- References -- Telomeres - Telomerase Biology and Their Role in Renal and Other Chronic Diseases -- Abstract -- 1. Introduction -- 2. Telomere Biology -- 3. Telomerase -- 4. Alternative Lengthening of Telomeres (ALT) -- 5. Telomeres and Telomerase Status in Certain Cell Types -- 6. Oxidative Stress. |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | 7. Telomeres and Molecular Senescence -- 8. Telomeres and Ageing -- 9. Telomeres and Disease -- 10. Therapeutics -- Conclusion -- References -- Telomerase and Telomere Dynamics in Cancer: Clinical Application for Cancer Diagnosis -- Abstract -- Abbreviations -- Introduction -- Telomere and Telomerase in Cancer Development -- Detecting Methods of Human Telomerase/Tert in Clinical Materials of Human Cancers -- Telomerase/Tert for Cancer Diagnosis -- Telomerase/Tert Detection in Clinical Materials -- Conclusion -- References -- Telomeres and Chromosome Segregation -- Abstract -- 1. Introduction -- 2. Telomere-Associated Proteins -- 3. Defective Telomere Structure and Consequences -- 4. Mitotic Chromosome Segregation and Telomeres -- Conclusion -- Acknowledgments -- References -- Telomere-Based Genome-Protective Responses: A Mammalian Improvement on the Bacterial SOS Response? -- Abstract -- Nature's Approach to Genome Protection: The SOS Response -- Evidence for a Telomere-Based Mammalian SOS Response -- Why Base the Mammalian SOS Response in the Telomere? -- Molecular Mechanism of Telomere Sequence-Initiated Signaling -- Harnessing the SOS Response: Pre-Clinical Experience -- Conclusion -- Conflict of Interest Disclosure -- References -- Telomere Lengthening from Oocyte to Embryonic Stem Cell -- Abstract -- Introduction -- Telomere Lengthening during Gametogenesis -- Telomere Lengthening during Preimplantation Development -- Telomere Length in Cloned and Manipulated Embryos -- Telomere Length in Male and Female Blastocysts -- Telomere Lengthening from Blastocyst to ES Cell -- References -- Transcriptional Activity at the Telomeres of Chironomus (Diptera). Its Possible Role in the Lengthening of the Telomeres -- Abstract -- 1. Introduction -- 2. The Organization of Chironomus Telomeres -- 3. Transcription at Chironomus Telomeres. |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | 4. The Possible Role of Telomeric Transcription in the Elongation Mechanism in Chironomus -- Acknowledgments -- References -- Telomerase Activity: Application to Diagnosis of Human Carcinoma -- Abstract -- Introduction -- Telomerase Activity -- Telomerase Detection Methods -- Telomerase and Cancer -- Conclusion -- References -- Telomere Shortening in Diabetes Mellitus -- Abstract -- Introduction -- Telomere Attrition in Diabetes Mellitus -- Mechanisms Linking Telomere Attrition with Diabetes Mellitus -- Telomere Attrition and Diabetic Complications -- Conclusion -- References -- Do Alterations in the Three-Dimensional Organization of Telomeres Indicate Malignant Transformation? -- Abstract -- The 3D Organization of the Nucleus -- Non-Random Organization of Telomeres in the Nucleus -- Functional Significance of Telomere Organization -- Telomeres and Cancer -- Telomeric Aggregates and Malignant Transformation -- 3D Telomere Organization in Hodgkin and Reed-Sternberg Cells of Hodgkin's Lymphoma: A Powerful Tool to Advance Knowledge of Lymphoma Biology -- Perspectives -- Acknowledgments -- References -- Telomeres: Function, Shortening, and Lengthening -- Abstract -- References -- Telomerase Regulation in Stem Cells- How to Flip the Switch? -- References -- Telomere Maintenance Mechanisms in Bone and Soft Tissue Tumors -- Abstract -- Introduction -- ALT Telomere Maintenance Mechanisms in Sarcomas -- Giant Cell Tumor of Bone -- Desmoid Tumor -- Osteosarcoma -- Ewing's Sarcoma -- Chondrosarcoma -- Malignant Fibrous Histiocytoma (MFH) -- Liposarcoma -- Summary and Perspective -- References -- Genetic Polymorphisms of Human Telomerase Reverse Transcriptase (hTERT). Mini Review -- Abstract -- Introduction -- Conclusion -- References -- Genetic Inhibition of Telomere Lengthening in Cancer Prevention and Treatment -- Abstract -- Introduction. |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Telomerase Inhibition in Cancer Therapy -- Deletion of the Telomerase Genes as a Preemptive Measure against Cancer -- Alternative Functions of Telomerase -- Technical Feasibility of hTERT Gene Targeting -- Replenishment of Stem Cells -- Alternative Lengthening of Telomeres -- Conclusion -- References -- Telomeres: Function, Shortening, and Lengthening -- Abstract -- References -- Clinical Implications of Telomerase Activity in Human Brain Tumors -- Abstract -- Introduction -- Glial Cell Tumors -- Conclusion -- References -- Index. |
| 588 ## - SOURCE OF DESCRIPTION NOTE | |
| Source of description note | Description based on publisher supplied metadata and other sources. |
| 590 ## - LOCAL NOTE (RLIN) | |
| Local note | Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Telomere. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Telomerase. |
| 655 #4 - INDEX TERM--GENRE/FORM | |
| Genre/form data or focus term | Electronic books. |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Relationship information | Print version: |
| Main entry heading | Mancini, Leonardo |
| Title | Telomeres |
| Place, publisher, and date of publication | New York : Nova Science Publishers, Incorporated,c2009 |
| International Standard Book Number | 9781606923504 |
| 797 2# - LOCAL ADDED ENTRY--CORPORATE NAME (RLIN) | |
| Corporate name or jurisdiction name as entry element | ProQuest (Firm) |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://ebookcentral.proquest.com/lib/orpp/detail.action?docID=3018589">https://ebookcentral.proquest.com/lib/orpp/detail.action?docID=3018589</a> |
| Public note | Click to View |
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