Bioseparations Science and Engineering. (Record no. 45787)
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| 000 -LEADER | |
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| fixed length control field | 11641nam a22006013i 4500 |
| 001 - CONTROL NUMBER | |
| control field | EBC1911965 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MiAaPQ |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20240729123340.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS | |
| fixed length control field | m o d | |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | cr cnu|||||||| |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 240724s2015 xx o ||||0 eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9780190213732 |
| Qualifying information | (electronic bk.) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| Canceled/invalid ISBN | 9780195391817 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (MiAaPQ)EBC1911965 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (Au-PeEL)EBL1911965 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (CaPaEBR)ebr11000834 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (CaONFJC)MIL688367 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (OCoLC)899942202 |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | MiAaPQ |
| Language of cataloging | eng |
| Description conventions | rda |
| -- | pn |
| Transcribing agency | MiAaPQ |
| Modifying agency | MiAaPQ |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER | |
| Classification number | TP248.25.S47.B567 2 |
| 082 0# - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 660/.2842 |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Harrison, Roger G. |
| 245 10 - TITLE STATEMENT | |
| Title | Bioseparations Science and Engineering. |
| 250 ## - EDITION STATEMENT | |
| Edition statement | 2nd ed. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | Oxford : |
| Name of producer, publisher, distributor, manufacturer | Oxford University Press, Incorporated, |
| Date of production, publication, distribution, manufacture, or copyright notice | 2015. |
| 264 #4 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | ©2015. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 1 online resource (577 pages) |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Content type code | txt |
| Source | rdacontent |
| 337 ## - MEDIA TYPE | |
| Media type term | computer |
| Media type code | c |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | online resource |
| Carrier type code | cr |
| Source | rdacarrier |
| 490 1# - SERIES STATEMENT | |
| Series statement | Topics in Chemical Engineering Series |
| 505 0# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Cover -- Bioseparations Science and Engineering -- Copyright -- Dedication -- Contents -- Preface -- 1 Introduction to Bioproducts and Bioseparations -- 1.1 Instructional Objectives -- 1.2 Broad Classification of Bioproducts -- 1.3 Small Biomolecules -- 1.3.1 Primary Metabolites -- 1.3.2 Secondary Metabolites -- 1.3.3 Summary of Small Biomolecules -- 1.4 Macromolecules: Proteins -- 1.4.1 Primary Structure -- 1.4.2 Secondary Structure -- 1.4.3 Tertiary Structure -- Example 1.1 Effect of a Reducing Agent on Protein Structure and Mobility -- 1.4.4 Quaternary Structure -- 1.4.5 Prosthetic Groups and Hybrid Molecules -- 1.4.6 Functions and Commercial Uses of Proteins -- 1.4.7 Stability of Proteins -- 1.4.8 Recombinant Protein Expression -- 1.5 Macromolecules: Nucleic Acids and Oligonucleotides -- 1.6 Macromolecules: Polysaccharides -- 1.7 Particulate Products -- 1.8 Introduction to Bioseparations: Engineering Analysis -- 1.8.1 Stages of Downstream Processing -- Example 1.2 Initial Selection of Purification Steps -- 1.8.2 Basic Principles of Engineering Analysis -- 1.8.3 Process and Product Quality -- 1.8.4 Criteria for Process Development -- 1.9 The Route to Market -- 1.9.1 The Chemical and Applications Range of the Bioproduct -- 1.9.2 Documentation of Pharmaceutical Bioproducts -- 1.9.3 GLP and cGMP -- 1.9.4 Formulation -- 1.10 Summary -- Nomenclature -- Problems -- References -- 2 Analytical Methods and Bench Scale Preparative Bioseparations -- 2.1 Instructional Objectives -- 2.2 Specifications -- 2.3 Assay Attributes -- 2.3.1 Precision -- 2.3.2 Accuracy -- 2.3.3 Specificity -- 2.3.4 Linearity, Limit of Detection, and Limit of Quantitation -- 2.3.5 Range -- 2.3.6 Robustness -- 2.4 Analysis of Biological Activity -- 2.4.1 Animal Model Assays -- 2.4.2 Cell-Line-Derived Bioassays -- 2.4.3 In vitro Biochemical Assays. |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Example 2.1 Coupled Enzyme Assay for Alcohol Oxidase -- 2.5 Analysis of Purity -- 2.5.1 Electrophoretic Analysis -- Example 2.2 Estimation of the Maximum Temperature in an Electrophoresis Gel -- 2.5.2 High-Performance Liquid Chromatography (HPLC) -- 2.5.3 Mass Spectrometry -- 2.5.4 Coupling of HPLC with Mass Spectrometry -- 2.5.5 Ultraviolet Absorbance -- Example 2.3 Determination of Molar Absorptivity -- 2.5.6 CHNO/Amino Acid Analysis (AAA) -- Example 2.4 Calculations Based on CHNO Analysis -- 2.5.7 Protein Assays -- 2.5.8 Enzyme-Linked Immunosorbent Assay -- 2.5.9 Gas Chromatography -- 2.5.10 DNA Hybridization -- 2.5.11 ICP/MS (AES) -- 2.5.12 Dry Weight -- 2.6 Microbiology Assays -- 2.6.1 Sterility -- 2.6.2 Bioburden -- 2.6.3 Endotoxin -- 2.6.4 Virus, Mycoplasma, and Phage -- 2.7 Bench Scale Preparative Separations -- 2.7.1 Preparative Electrophoresis -- 2.7.2 Magnetic Bioseparations -- 2.8 Summary -- Nomenclature -- Problems -- References -- 3 Cell Lysis and Flocculation -- 3.1 Instructional Objectives -- 3.2 Some Elements of Cell Structure -- 3.2.1 Prokaryotic Cells -- 3.2.2 Eukaryotic Cells -- 3.3 Cell Lysis -- 3.3.1 Osmotic and Chemical Cell Lysis -- 3.3.2 Mechanical Methods of Lysis -- 3.4 Flocculation -- 3.4.1 The Electric Double Layer -- Example 3.1 Dependence of the Debye Radius on the Type of Electrolyte -- 3.4.2 Forces Between Particles and Flocculation by Electrolytes -- Example 3.2 Sensitivity of Critical Flocculation Concentration to Temperature and Counterion Charge Number -- 3.4.3 The Schulze-Hardy Rule -- 3.4.4 Flocculation Rate -- 3.4.5 Polymeric Flocculants -- 3.5 Summary -- Nomenclature -- Problems -- References -- 4 Filtration -- 4.1 Instructional Objectives -- 4.2 Filtration Principles -- 4.2.1 Conventional Filtration -- Example 4.1 Batch Filtration -- 4.2.2 Crossflow Filtration. |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Example 4.2 Concentration Polarization in Ultrafiltration -- Example 4.3 Comparison of Mass Transfer Coefficient Calculated by Boundary Layer Theory Versus by Shear-Induced Diffusion Theory -- 4.3 Filter Media and Equipment -- 4.3.1 Conventional Filtration -- 4.3.2 Crossflow Filtration -- 4.4 Membrane Fouling -- 4.5 Scale-up and Design of Filtration Systems -- 4.5.1 Conventional Filtration -- Example 4.4 Rotary Vacuum Filtration -- Example 4.5 Washing of a Rotary Vacuum Filter Cake -- 4.5.2 Crossflow Filtration -- Example 4.6 Diafiltration Mode in Crossflow Filtration -- 4.6 Summary -- Nomenclature -- Problems -- References -- 5 Sedimentation -- 5.1 Instructional Objectives -- 5.2 Sedimentation Principles -- 5.2.1 Equation of Motion -- 5.2.2 Sensitivities -- 5.3 Methods for Analysis of Sedimentation -- 5.3.1 Equilibrium Sedimentation -- 5.3.2 Sedimentation Coefficient -- Example 5.1 Application of the Sedimentation Coefficient -- 5.3.3 Equivalent Time -- Example 5.2 Scale-up Based on Equivalent Time -- 5.3.4 Sigma Analysis -- 5.4 Production Centrifuges: Comparison and Engineering Analysis -- 5.4.1 Tubular Bowl Centrifuge -- Example 5.3 Complete Recovery of Bacterial Cells in a Tubular Bowl Centrifuge -- 5.4.2 Disk Centrifuge -- 5.5 Ultracentrifugation -- 5.5.1 Determination of Molecular Weight -- 5.6 Flocculation and Sedimentation -- 5.7 Sedimentation at Low Accelerations -- 5.7.1 Diffusion, Brownian Motion -- 5.7.2 Isothermal Settling -- 5.7.3 Convective Motion and Péclet Analysis -- 5.7.4 Inclined Sedimentation -- 5.7.5 Field-Flow Fractionation -- 5.8 Centrifugal Elutriation -- 5.9 Summary -- Nomenclature -- Problems -- References -- 6 Extraction -- 6.1 Instructional Objectives -- 6.2 Extraction Principles -- 6.2.1 Phase Separation and Partitioning Equilibria -- 6.2.2 Countercurrent Stage Calculations. |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Example 6.1 Separation of a Bioproduct and an Impurity by Countercurrent Extraction -- Example 6.2 Effect of Solvent Rate in Countercurrent Staged Extraction of an Antibiotic -- 6.3 Scale-up and Design of Extractors -- 6.3.1 Reciprocating-Plate Extraction Columns -- Example 6.3 Scale-up of a Reciprocating-Plate Extraction Column -- 6.3.2 Centrifugal Extractors -- Example 6.4 Increase in Feed Rate to a Podbielniak Centrifugal Extractor -- 6.4 Summary -- Nomenclature -- Problems -- References -- 7 Liquid Chromatography and Adsorption -- 7.1 Instructional Objectives -- 7.2 Adsorption Equilibrium -- 7.3 Adsorption Column Dynamics -- 7.3.1 Fixed-Bed Adsorption -- Example 7.1 Determination of the Mass Transfer Coefficient from Adsorption Breakthrough Data -- 7.3.2 Agitated-Bed Adsorption -- 7.4 Chromatography Column Dynamics -- 7.4.1 Plate Models -- 7.4.2 Moment Analysis -- 7.4.3 Chromatography Column Mass Balance with Negligible Dispersion -- Example 7.2 Chromatographic Separation of Two Solutes -- Example 7.3 Calculation of the Shock Wave Velocity for a Nonlinear Isotherm -- Example 7.4 Calculation of the Elution Profile -- 7.4.4 Dispersion Effects in Chromatography -- 7.4.5 Computer Simulation of Chromatography Considering Axial Dispersion, Fluid-Phase Mass Transfer, Intraparticle Diffusion, and Nonlinear Equilibrium -- 7.4.6 Gradients and Modifiers -- Example 7.5 Equilibrium for a Protein Anion in the Presence of Chloride Ion -- 7.5 Membrane Chromatography -- Example 7.6 Comparison of Time for Diffusion Mass Transfer in Conventional Chromatography and Membrane Chromatography -- 7.6 Simulated Moving Bed Chromatography -- 7.7 Adsorbent Types -- 7.7.1 Silica-Based Resins -- 7.7.2 Polymer-Based Resins -- 7.7.3 Ion Exchange Resins -- 7.7.4 Reversed-Phase Chromatography -- 7.7.5 Hydrophobic Interaction Chromatography. |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | 7.7.6 Affinity Chromatography -- 7.7.7 Immobilized Metal Affinity Chromatography (IMAC) -- 7.7.8 Size Exclusion Chromatography -- 7.8 Particle Size and Pressure Drop in Fixed Beds -- 7.9 Equipment -- 7.9.1 Columns -- 7.9.2 Chromatography Column Packing Procedures -- 7.9.3 Detectors -- 7.9.4 Chromatography System Fluidics -- 7.10 Scale-up -- 7.10.1 Adsorption -- Example 7.7 Scale-up of the Fixed-Bed Adsorption of a Pharmaceutical Product -- 7.10.2 Chromatography -- Example 7.8 Scale-up of a Protein Chromatography -- Example 7.9 Scale-up of Protein Chromatography Using Standard Column Sizes -- Example 7.10 Scale-up of Elution Buffer Volumes in Protein Chromatography -- Example 7.11 Consideration of Pressure Drop in Column Scaling -- 7.11 Summary -- Nomenclature -- Problems -- References -- 8 Precipitation -- 8.1 Instructional Objectives -- 8.2 Protein Solubility -- 8.2.1 Structure and Size -- 8.2.2 Charge -- 8.2.3 Solvent -- Example 8.1 Salting Out of a Protein with Ammonium Sulfate -- 8.3 Precipitate Formation Phenomena -- 8.3.1 Initial Mixing -- 8.3.2 Nucleation -- 8.3.3 Growth Governed by Diffusion -- Example 8.2 Calculation of Concentration of Nuclei in a Protein Precipitation -- Example 8.3 Diffusion-Limited Growth of Particles -- 8.3.4 Growth Governed by Fluid Motion -- Example 8.4 Growth of Particles Limited by Fluid Motion -- 8.3.5 Precipitate Breakage -- 8.3.6 Precipitate Aging -- 8.4 Particle Size Distribution in a Continuous-Flow Stirred Tank Reactor -- Example 8.5 Dependence of Population Density on Particle Size and Residence Time in a CSTR -- 8.5 Methods of Precipitation -- 8.6 Design of Precipitation Systems -- 8.7 Summary -- Nomenclature -- Problems -- References -- 9 Crystallization -- 9.1 Instructional Objectives -- 9.2 Crystallization Principles -- 9.2.1 Crystals -- 9.2.2 Nucleation -- 9.2.3 Crystal Growth. |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | 9.2.4 Crystallization Kinetics from Batch Experiments. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | An updated edition of a comprehensive and authoritative chemical engineering textbook on bioseparations science, updated to include new information on topics like moment analysis, chromatography, and evaporation. |
| 588 ## - SOURCE OF DESCRIPTION NOTE | |
| Source of description note | Description based on publisher supplied metadata and other sources. |
| 590 ## - LOCAL NOTE (RLIN) | |
| Local note | Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Biomolecules -- Separation. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Biochemical engineering. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Separation (Technology). |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Extraction (Chemistry). |
| 655 #4 - INDEX TERM--GENRE/FORM | |
| Genre/form data or focus term | Electronic books. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Todd, Paul W. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rudge, Scott R. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Petrides, Demetri P. |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Relationship information | Print version: |
| Main entry heading | Harrison, Roger G. |
| Title | Bioseparations Science and Engineering |
| Place, publisher, and date of publication | Oxford : Oxford University Press, Incorporated,c2015 |
| International Standard Book Number | 9780195391817 |
| 797 2# - LOCAL ADDED ENTRY--CORPORATE NAME (RLIN) | |
| Corporate name or jurisdiction name as entry element | ProQuest (Firm) |
| 830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE | |
| Uniform title | Topics in Chemical Engineering Series |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://ebookcentral.proquest.com/lib/orpp/detail.action?docID=1911965">https://ebookcentral.proquest.com/lib/orpp/detail.action?docID=1911965</a> |
| Public note | Click to View |
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