International Textbook of Diabetes Mellitus. (Record no. 44604)
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| fixed length control field | 11154nam a22005173i 4500 |
| 001 - CONTROL NUMBER | |
| control field | EBC1895437 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MiAaPQ |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20240729123257.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS | |
| fixed length control field | m o d | |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | cr cnu|||||||| |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 240724s2015 xx o ||||0 eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9781118387689 |
| Qualifying information | (electronic bk.) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| Canceled/invalid ISBN | 9780470658611 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (MiAaPQ)EBC1895437 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (Au-PeEL)EBL1895437 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (CaPaEBR)ebr11030441 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (CaONFJC)MIL769815 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (OCoLC)906183038 |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | MiAaPQ |
| Language of cataloging | eng |
| Description conventions | rda |
| -- | pn |
| Transcribing agency | MiAaPQ |
| Modifying agency | MiAaPQ |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER | |
| Classification number | RC660.4 -- .I584 2015eb |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | DeFronzo, R. A. |
| 245 10 - TITLE STATEMENT | |
| Title | International Textbook of Diabetes Mellitus. |
| 250 ## - EDITION STATEMENT | |
| Edition statement | 4th ed. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | Newark : |
| Name of producer, publisher, distributor, manufacturer | John Wiley & Sons, Incorporated, |
| Date of production, publication, distribution, manufacture, or copyright notice | 2015. |
| 264 #4 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | ©2015. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 1 online resource (1203 pages) |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Content type code | txt |
| Source | rdacontent |
| 337 ## - MEDIA TYPE | |
| Media type term | computer |
| Media type code | c |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | online resource |
| Carrier type code | cr |
| Source | rdacarrier |
| 505 0# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Cover -- Contents -- Contributors -- Preface -- Section I Epidemiology -- Chapter 1 Classification of diabetes mellitus and other categories of glucose intolerance -- Introduction -- Historical perspective and current classifications -- Previous classifications -- Current classification -- Type 1 process -- Type 2 process -- Other specific types -- Classification of genetic disorders -- Genetic defects of β-cell function -- Genetic defects in insulin action -- Diseases of the exocrine pancreas -- Endocrinopathies -- Drug-or chemical-induced diabetes -- Infections -- Uncommon but specific forms of immune-mediated diabetes mellitus -- Other genetic syndromes associated with diabetes -- Diabetes in children and youth -- Diagnosis of diabetes using HbA1c -- Diagnosis of gestational diabetes mellitus -- Impaired glucose regulation (impaired glucose tolerance and impaired fasting glycemia) -- Normoglycemia -- Summary -- References -- Chapter 2 Epidemiology and risk factors for type 1 diabetes mellitus -- Introduction -- Prevalence and incidence -- Geographic location -- Race and ethnicity -- Age and gender -- Increasing incidence and seasonality -- β-Cell autoimmunity and risk factors -- Family history of T1DM -- HLA class II susceptibility genotypes -- Other genetic factors associated with type 1 diabetes -- Islet autoantibodies -- Autoantibody screening among relatives -- Autoantibody screening in the general population -- Measurement of autoantibodies in adult-onset diabetes -- Measurement of β-cell function -- Environmental factors -- Gene-environment interaction in clinical type 1 diabetes -- Established type 1 diabetes -- Clinical onset -- Remission (honeymoon period) -- Acute complications -- Morbidity and mortality -- References -- Chapter 3 Epidemiology and geography of type 2 diabetes mellitus. |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Age- and sex-specific prevalence of type 2 diabetes in different ethnic groups -- Diagnostic criteria for diabetes -- Conversion factors for glucose concentrations -- Age- and sex-specific plasma glucose concentration -- Age- and sex-specific prevalence of diabetes -- Previously undiagnosed diabetes -- Prevalence of impaired glucose tolerance and impaired fasting glycemia in different ethnic groups -- Europe -- Asia -- Sex differences in prevalence of diabetes, IGT, and IFG -- The ratio of IGT to diabetes -- Secular trends in prevalence of type 2 diabetes -- Type 2 diabetes in children -- Prevalence and incidence -- Characteristics and diagnosis -- Risk factors -- Complications and comorbid conditions -- Modifiable risk factors for type 2 diabetes -- Obesity -- Physical activity -- Dietary factors -- Nontraditional modifiable risk factors for type 2 diabetes -- Inflammation -- Smoking -- References -- Section II Physiology of pancreatic function -- Chapter 4 Development and maintenance of the islet β cell -- Introduction -- Pancreas development -- Induction of the definitive endoderm -- Patterning of the gut tube into organ domains -- Induction of the dorsal and ventral pancreatic buds -- Pancreatic growth and epithelial branching morphogenesis -- Cytodifferentiation in the developing pancreas -- Tip versus trunk domains -- Endocrine versus exocrine cell fate decision -- The endocrine progenitor cell -- What makes a β cell? -- Translating pancreas development into cell-based therapies for diabetes -- Postnatal β-cell growth and maintenance -- Neonatal β-cell turnover -- β-Cell growth with aging -- Compensatory β-cell growth: adaptation to demand -- Origins of new β cells in the adult: neogenesis, transdifferentiation, and replication -- Regulators of β-cell growth: growth factors and cell cycle regulators -- Conclusions and areas of future study. |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | References -- Chapter 5 Pancreatic morphology in normal and diabetic states -- Pancreatic anatomy and morphology -- Islet composition and morphology -- Islet β cell regenerative potential -- Disturbances in pancreas/islet morphology in diabetes -- Type 1 diabetes -- Type 2 diabetes -- Influence of exocrine pancreas abnormalities on islet morphology and function -- Mechanisms of β-cell loss in type 2 diabetes -- Chronically elevated glucose and/or free fatty acids -- Islet amyloid -- Islet inflammation -- Summary and future directions -- Acknowledgments -- References -- Chapter 6 Insulin gene expression and biosynthesis -- Introduction -- Insulin gene expression -- Structure of the insulin gene -- Physiologic regulation of insulin gene expression -- Dysregulation of the insulin gene -- Insulin biosynthesis -- Introduction -- Structure of the insulin molecule -- Proinsulin biosynthesis: translation and translocation -- Proinsulin biosynthesis: effectors and stimulus-response coupling mechanisms -- Proinsulin biosynthesis: translational control mechanism -- Transport of proinsulin from the ER to Golgi apparatus -- Proteolytic enzymes of proinsulin conversion -- Regulation of proinsulin conversion -- The mature β-granule storage pool -- Dysfunctional proinsulin processing in diabetes -- Acknowledgments -- References -- Chapter 7 β-Cell biology of insulin secretion -- Introduction -- β-Cell metabolism -- Glucose sensing glycolysis -- Mitochondrial metabolism -- ATP generation in the respiratory chain -- NADH shuttles -- Lipid metabolism -- Metabolism-secretion coupling -- Triggering pathway -- Metabolic amplifying pathway -- Dynamics of insulin secretion -- Biphasic insulin secretion -- Exocytotic machinery -- Modulation of insulin secretion by various intracellular signals -- Gs-protein-coupled receptor -- Gq-protein-coupled receptor. |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Gi/o-protein-coupled receptors -- Autocrine effect of insulin on insulin secretion -- Pathophysiology of pancreatic β cells -- β-Cell mass and function in type 2 diabetes -- Abnormalities in the dynamics of insulin secretion -- Conclusions -- References -- Chapter 8 Normal β-cell function -- Introduction -- Methods for the assessment of insulin secretion -- Relationship between plasma insulin concentration and insulin secretion -- Insulin secretion indices -- Mathematical models -- β-Cell response to intravenous glucose -- The hyperglycemic clamp -- The intravenous glucose tolerance test -- β-Cell response to oral glucose -- The incretin effect -- Insulin secretion mechanisms during an oral glucose load -- Insulin secretion in normal living conditions -- β-Cell response to nonglucose secretagogues -- Proteins and amino acids -- Lipids and free fatty acids -- Slow β-cell response modes and adaptation mechanisms -- Glucose-induced potentiation of insulin secretion -- Adaptation to insulin sensitivity -- β-Cell response to hormones and the nervous system -- Pulsatile secretion of insulin -- β-Cell mass and function -- Insulin clearance -- Insulin clearance in fasting conditions -- Insulin clearance in the fed state -- β-Cell function and glucose homeostasis -- Conclusions -- References -- Chapter 9 Neuropeptides and islet hormone secretion -- Introduction -- Islet parasympathetic nerves -- Gastrin-releasing polypeptide (GRP) -- Vasoactive intestinal polypeptide (VIP) -- Pituitary adenylate cyclase-activating polypeptide (PACAP) -- Parasympathetic effects and mediation -- Islet sympathetic nerves -- Galanin -- Neuropeptide Y (NPY) -- Sympathetic effects and mediation -- Islet sensory neuropeptides -- Calcitonin gene-related polypeptide (CGRP) -- Substance P -- Summary of present-day knowledge -- Questions for future research. |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | What are the physiologic roles of the islet autonomic nerves? -- What is the contribution of neuropeptides? -- Do the autonomic nerves contribute to development of type 2 diabetes? -- Is islet neurotransmission a therapeutic target for type 2 diabetes? -- Acknowledgments -- References -- Chapter 10 Biosynthesis, secretion, and action of glucagon -- Introduction -- Amino acid composition, extraction, synthesis, and biosynthesis -- Physiologic effects of glucagon -- Other effects of glucagon -- Control of glucagon release -- Some aspects of glucagon physiology and pathophysiology -- Glucagon as a counterregulatory hormone -- Glucagon in exercise -- Glucagon in stress -- Glucagon in starvation -- Glucagon and adaptation to extrauterine life -- Glucagon and diabetes -- The glucagonoma syndrome -- References -- Chapter 11 Incretin physiology in health and disease -- The incretin effect in health -- Secretion of incretin hormones -- Degradation and elimination of incretin hormones -- Physiologic effects of incretin hormones -- GLP-1 -- GIP -- Other gastrointestinal hormones with potential incretin function -- Cholecystokinin (CCK) -- Secretin -- Gastrin -- The incretin effect in patients with diabetes -- Potential mechanisms of incretin dysfunction in type 2 diabetes -- Summary and conclusions -- References -- Section III Normal physiology of insulin action -- Chapter 12 Mechanisms of insulin signal transduction -- Introduction -- Fuel homeostasis -- Changing perspectives of insulin action -- Insulin resistance -- Insulin receptors -- Ligand binding -- Tyrosine kinase activity -- Insulin-like growth factors -- Hybrid receptors -- Insulin receptor mutations -- Insulin receptor substrate molecules -- Receptor substrate/docking proteins -- Insulin receptor substrate (IRS) family of docking proteins -- Other receptor substrates. |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Proteins that dock with receptor substrate molecules. |
| 588 ## - SOURCE OF DESCRIPTION NOTE | |
| Source of description note | Description based on publisher supplied metadata and other sources. |
| 590 ## - LOCAL NOTE (RLIN) | |
| Local note | Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Diabetes -- Popular works. |
| 655 #4 - INDEX TERM--GENRE/FORM | |
| Genre/form data or focus term | Electronic books. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ferrannini, E. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Zimmet, Paul. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Alberti, George. |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Relationship information | Print version: |
| Main entry heading | DeFronzo, R. A. |
| Title | International Textbook of Diabetes Mellitus |
| Place, publisher, and date of publication | Newark : John Wiley & Sons, Incorporated,c2015 |
| International Standard Book Number | 9780470658611 |
| 797 2# - LOCAL ADDED ENTRY--CORPORATE NAME (RLIN) | |
| Corporate name or jurisdiction name as entry element | ProQuest (Firm) |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://ebookcentral.proquest.com/lib/orpp/detail.action?docID=1895437">https://ebookcentral.proquest.com/lib/orpp/detail.action?docID=1895437</a> |
| Public note | Click to View |
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