Leishmania : (Record no. 13414)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 07771nam a22004573i 4500 |
| 001 - CONTROL NUMBER | |
| control field | EBC5897804 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MiAaPQ |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20240724113940.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS | |
| fixed length control field | m o d | |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | cr cnu|||||||| |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 240724s2015 xx o ||||0 eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9781908230539 |
| Qualifying information | (electronic bk.) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| Canceled/invalid ISBN | 9781908230522 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (MiAaPQ)EBC5897804 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (Au-PeEL)EBL5897804 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (OCoLC)896842821 |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | MiAaPQ |
| Language of cataloging | eng |
| Description conventions | rda |
| -- | pn |
| Transcribing agency | MiAaPQ |
| Modifying agency | MiAaPQ |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER | |
| Classification number | QL368.K5 .L457 2015 |
| 082 0# - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 593.18 |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Adak, Subrata. |
| 245 10 - TITLE STATEMENT | |
| Title | Leishmania : |
| Remainder of title | Current Biology and Control. |
| 250 ## - EDITION STATEMENT | |
| Edition statement | 1st ed. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | Norfolk : |
| Name of producer, publisher, distributor, manufacturer | Caister Academic Press, |
| Date of production, publication, distribution, manufacture, or copyright notice | 2015. |
| 264 #4 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | ©2015. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 1 online resource (258 pages) |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Content type code | txt |
| Source | rdacontent |
| 337 ## - MEDIA TYPE | |
| Media type term | computer |
| Media type code | c |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | online resource |
| Carrier type code | cr |
| Source | rdacarrier |
| 505 0# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Intro -- Contents -- Contributors -- Current Books of Interest -- Preface -- 1: Modulation of Host Cell miRNA Expression During Leishmania Infection and Emergence of miRNA as a New Therapeutic Molecule -- miRNA-mediated gene regulation in metazoan animals -- miRNA as regulator of cholesterol metabolism in mammals -- Cholesterol regulates pathogenesis of Leishmania donovani -- Leishmania-mediated changes in cholesterol production in mammals -- miRNA expression affected by parasite -- Mechanism of miRNA alteration by Leishmania -- Factors important for host cell miRNA alteration during infection -- miRNA as therapeutic agent -- Future of miRNA as a therapeutic agent against visceral leishmaniasis -- 2: Heat Shock Proteins of Leishmania: Chaperones in the Driver's Seat -- Introduction: heat shock proteins -- Heat shock proteins in Leishmania spp. -- Leishmania and the cell stress -- The pitfalls of analogy-based assumptions -- The chaperone machinery and signal transduction in Leishmania -- Open questions -- Future trends -- Acknowledgements -- 3: Role of Iron in Leishmania-Macrophage Interaction -- Introduction -- Aqueous chemistry and toxicity of iron -- Role of iron in physiology -- Role of iron in the host-parasite interaction -- Special need of iron for Leishmania -- Mammalian iron homeostasis components important for sequestering iron -- Regulation of cellular iron metabolism of mammalian host -- Source of host iron and its acquisition systems in Leishmania -- Summary and future aspects -- 4: Oxidative and Nitrosative Stress Response in Leishmania -- Introduction -- Sources of superoxide and hydrogen peroxide in Leishmania -- Targets of reactive oxygen species in Leishmania -- Defence against reactive oxygen species -- Nitrosative stress in Leishmania -- Generation of reactive nitrogen species. |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Targets of reactive nitrogen species (RNS) in Leishmania -- Cellular defences against nitrosative stress in Leishmania -- Conclusion -- Future perspectives -- 5: Cell Death in a Kinetoplastid Parasite, the Leishmania spp. -- Introduction -- Life cycle of Leishmania spp. -- Treatment of leishmaniasis -- Programmed cell death (PCD) -- Programmed cell death in protozoan parasites -- Relevance of studying cell death in Leishmania -- Apoptosis in Leishmania -- Natural cell death during cell cycle -- Induction of cell death by anti-leishmanial drugs -- Oxidative stress induced cell death -- Role of apoptotic mimicry and apoptosis in Leishmania -- Autophagy in Leishmania -- Future trends -- Conclusion -- 6: Elucidating the Strategies of Immune Evasion by Leishmania -- Introduction -- Defying recognition by the host: modulation of Toll-like receptor-mediated signalling -- Deactivation of host signalling: mitogen-activated protein (MAP) kinases and phosphatases -- Disarming the enemy: inhibition of host microbicidal molecules -- Delaying phagosome maturation: buying time for promastigote to amastigote conversion -- Creating a favourable environment: polarization of Th (T-helper cell) response -- Suppression of antigen presentation: escaping cytotoxic T-cell response -- Protection of niche: inhibition of macrophage apoptosis by Leishmania parasites -- Conclusion -- 7: Role of STAT Signalling in Immunity to Leishmaniasis -- Introduction -- STAT1 and leishmaniasis -- STAT2 and leishmaniasis -- STAT3 and leishmaniasis -- STAT4 and leishmaniasis -- STAT6 and leishmaniasis -- Conclusion -- 8: Leishmania Modulates Toll-like Receptor Signalling in Macrophages -- Introduction -- Innate immune receptors on antigen-presenting cell, macrophage -- Toll-like receptors: structure and its agonists -- Interaction of Leishmania and macrophages. |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Toll-like receptor signalling upon stimulation with Leishmania surface antigen -- The cumulative effect of Leishmania infection on Toll-like receptors and intra-pattern recognition receptor signalling -- Changes in cytokine synthesis upon synergy within Toll-like receptor stimulations -- Toll-like receptor-Toll-like receptor cross-talk -- Conclusion and future trends -- 9: Role of T-cells in Leishmania Infection -- Introduction -- The widening horizons of T-helper subsets -- CD8+ T-cells response -- T-reg cells as master regulators of immunosuppression -- Evolution of the concept of T-regs in leishmaniasis - a time line -- Contra-regulation -- T-reg biology: lesson learned from leishmaniasis -- T-reg targeting in anti-leishmanial immunotherapy -- Unanswered questions and future perspectives -- Concluding remarks -- 10: Vaccine Biology of Leishmania Infection -- Introduction -- Immunology of Leishmania infection -- Challenges in vaccine development against leishmaniasis -- Rationale of vaccine development against leishmaniasis -- General methods to evaluate vaccine potentials against leishmaniasis -- Antigenic components of Leishmania vaccine -- Vaccine for canine leishmaniasis -- Therapeutic vaccines -- Adjuvants and delivery system -- Summary -- 11: Inhibitors of DNA Topoisomerases as Potential Anti-leishmanial Agents -- Introduction -- Kinetoplastid protozoans express two different kinds of topoisomerases -- Evolutionary aspects of kinetoplastid topoisomerase I and topoisomerase II -- Topoisomerases as therapeutic targets -- Classification of topoisomerase inhibitors -- Topoisomerases as targets for antiparasitic agents -- Conclusion -- 12: Mechanism of Drug Resistance in Visceral Leishmaniasis -- Introduction -- Mechanism of drug resistance -- Conclusion and future trends -- Index. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | In this timely book respected Leismania experts distil the important current research highlighting the most insightful discoveries in the field. Topics covered include: modulation of host miRNA; heat shock proteins; Iron in the Leishmania-macrophage interaction; oxidative and nitrosative stress response; cell death; strategies for immune evasion; STAT signalling; parasite modulation of toll-like receptors in macrophages; T cells in Leishmania infection; vaccine biology; inhibitors of Leishmania DNA topoisomerases; and mechanism of drug resistance in visceral Leishmaniasis. An essential text for everyone in the Leishmania community and recommended for researchers working in related fields. |
| 588 ## - SOURCE OF DESCRIPTION NOTE | |
| Source of description note | Description based on publisher supplied metadata and other sources. |
| 590 ## - LOCAL NOTE (RLIN) | |
| Local note | Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Leishmania. |
| 655 #4 - INDEX TERM--GENRE/FORM | |
| Genre/form data or focus term | Electronic books. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Datta, Rupak. |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Relationship information | Print version: |
| Main entry heading | Adak, Subrata |
| Title | Leishmania |
| Place, publisher, and date of publication | Norfolk : Caister Academic Press,c2015 |
| International Standard Book Number | 9781908230522 |
| 797 2# - LOCAL ADDED ENTRY--CORPORATE NAME (RLIN) | |
| Corporate name or jurisdiction name as entry element | ProQuest (Firm) |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://ebookcentral.proquest.com/lib/orpp/detail.action?docID=5897804">https://ebookcentral.proquest.com/lib/orpp/detail.action?docID=5897804</a> |
| Public note | Click to View |
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