Molecular Biology of Kinetoplastid Parasites. (Record no. 13412)
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| fixed length control field | 07282nam a22004453i 4500 |
| 001 - CONTROL NUMBER | |
| control field | EBC5897802 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MiAaPQ |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20240724113940.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS | |
| fixed length control field | m o d | |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | cr cnu|||||||| |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 240724s2018 xx o ||||0 eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9781910190722 |
| Qualifying information | (electronic bk.) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| Canceled/invalid ISBN | 9781910190715 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (MiAaPQ)EBC5897802 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (Au-PeEL)EBL5897802 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (OCoLC)1028552451 |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | MiAaPQ |
| Language of cataloging | eng |
| Description conventions | rda |
| -- | pn |
| Transcribing agency | MiAaPQ |
| Modifying agency | MiAaPQ |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER | |
| Classification number | QL368.K5 .M654 2018 |
| 082 0# - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 593.18 |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Majumder, Hemanta K. |
| 245 10 - TITLE STATEMENT | |
| Title | Molecular Biology of Kinetoplastid Parasites. |
| 250 ## - EDITION STATEMENT | |
| Edition statement | 1st ed. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | Norfolk : |
| Name of producer, publisher, distributor, manufacturer | Caister Academic Press, |
| Date of production, publication, distribution, manufacture, or copyright notice | 2018. |
| 264 #4 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | ©2018. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 1 online resource (256 pages) |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Content type code | txt |
| Source | rdacontent |
| 337 ## - MEDIA TYPE | |
| Media type term | computer |
| Media type code | c |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | online resource |
| Carrier type code | cr |
| Source | rdacarrier |
| 505 0# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Intro -- Contents -- Preface -- Current Books of Interest -- About the Editor -- 1. Genome-wide Profiling of Unique Domain Architectures Reveals Novel Epigenetic Regulators of Leishmania infantum -- Introduction -- Results and discussion -- Conclusion -- Materials and methods -- 2. Role of Hypoxia Inducible Factor-1 in Leishmania-Macrophage Interaction: -- Introduction -- Structure of HIF-1 -- Regulation of HIF-1α -- Regulation of HIF-1 activity -- Role of HIF-1 in physiology -- Role of HIF-1 in infection and innate immunity -- HIF-1 as possible drug target in visceral form of leishmaniasis -- 3. Response of B Lymphocytes During Leishmania Infection -- Leishmaniasis -- Immune system elements -- Host immune response -- B-cell development and functions of B-cells -- B-cell pathogenicity during Leishmania infection -- Developmental deregulation of B-cells during pathological condition -- Regulatory B-cells -- Secretion of IL-10 from B-lymphocytes during Leishmania infection -- 4. Cellular Defence of the Leishmania Parasite -- Introduction -- Distribution -- Life cycle -- Treatment -- Challenges in the field of treatment -- Parasite's defence arsenal -- Host manipulation by parasite -- Molecular Regulation of Macrophage Class Switching in Indian Post-kala-azar Dermal Leishmaniasis (PKDL) -- Introduction -- Historical background of PKDL -- Clinical features of PKDL -- Alternative activation of macrophages and disease etiopathogenesis of PKDL -- Status of cytokine milieu in dermal leishmaniasis -- Toll-like receptors in PKDL -- Status of reactive oxygen and nitrogen intermediates in PKDL -- Attenuated phosphorylation of p-38 and ERK in PKDL -- Role of host and parasite arginase 1 in PKDL -- Status of co-stimulatory molecules, CD80/CD 86 in PKDL -- Role of vitamin D in Indian PKDL -- Status of MRC 1 in Indian PKDL. |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | 6. Leishmania Exploits Host's Defence Machineries for Survival: A Tale of Immune Evasion -- Introduction -- Early stages of infection -- Mid stages of infection -- Late stages of infection -- Protecting own niche: prevention of host cell apoptosis -- Ceramide in the Establishment of Visceral Leishmaniasis, an Insight into Membrane Architecture and Pathogenicity -- Introduction -- Pathways of ceramide biosynthesis -- Ceramide an important component of inflammatory response -- Role of ceramide in infectious diseases -- Biphasic role of ceramide during visceral leishmaniasis -- Ceramide-mediated impairment in antigen presentation -- Ceramide mediated regulation of kinases and phosphatises -- Modulation of T-cell subsets through ceramide generation during visceral leishmaniasis -- 8. The Role of Haemproteins in Different Life Cycle Stages of Leishmania -- Introduction -- Haem and haem containing proteins -- Leishmania need haem for survival -- Source of haem and its acquisition systems in Leishmania -- Role of different types of haemproteins in eukaryotes and prokaryotes -- Conclusions -- Future trends -- 9. Pre-adaptation of Leishmania Promastigotes to Intracellular Life: Ensuring a Successful Infection -- Introduction -- Membrane and cytoskeleton-sensing the changes -- Parasite exoproteome-modulating the host -- Cytosolic proteins: a pool of stress busters -- The metabolic adaptations -- The global picture of parasite preadaptation -- Concluding remarks -- 10. DNA Topoisomerases of Kinetoplastid Parasites: Brief Overview and Recent Perspectives -- Introduction -- Different topoisomerases of kinetoplastid parasites -- Exploiting the topoisomerases of kinetoplastid parasites for therapeutic interventions -- Conclusion and future perspectives. |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | 11. Host-Kinetoplastid Parasite Interaction at the Immune System Interface: Immune Evasion and Immunotherapy -- Introduction -- Molecular host-parasite interaction and strategies of immune evasion by the parasite -- Morphological characterization of kinetoplastids -- Leishmania -- Trypanosoma -- Development of immunotherapeuetics -- Vaccination using parasite derived immunogenic components -- Conclusion -- 12. Extracellular Matrix Interacting Proteins of Trypanosomatids: Adhesion and Invasion of Host Tissues -- Introduction -- General overview of extracellular matrix components -- Mechanism of extracellular matrix interaction by the extracellular matrix interacting proteins -- Synopsis -- 13. Effects of Phospholipid Analogues on Trypanosomatids -- Introduction -- Phospholipids and their importance for the cell -- Phospholipids biosynthetic pathways in mammalian cells and in trypanosomatids -- Design and synthesis of phospholipid analogues -- Effect of phospholipid analogues on the growth and morphology of trypanosomatids -- Cell death processes and immunomodulatory effects induced by phospholipid analogues -- A critical view of the use of miltefosine for treatment of leishmaniasis -- Index. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Written by a team of authors active in the field of Leishmania and Trypanosoma research, this volume reviews the current research in kinetoplastid parasites. With an emphasis on cellular and molecular biology, areas covered include epigenetic regulation, cellular defence, manipulation of host macrophages, B lymphocyte response, adhesion and invasion of host tissues, immune evasion, immunotherapy, hemeproteins, phospholipids biosynthesis and DNA topoisomerases. A common theme throughout the book is the identification of new therapeutic targets for drug development. This timely and up-to-date volume is essential reading for anyone working on kinetoplastid parasites and will also be of interest to parasitologists, immunologists and drug development researchers. All parasitology laboratories should have a copy of this important reference volume. |
| 588 ## - SOURCE OF DESCRIPTION NOTE | |
| Source of description note | Description based on publisher supplied metadata and other sources. |
| 590 ## - LOCAL NOTE (RLIN) | |
| Local note | Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Kinetoplastida. |
| 655 #4 - INDEX TERM--GENRE/FORM | |
| Genre/form data or focus term | Electronic books. |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Relationship information | Print version: |
| Main entry heading | Majumder, Hemanta K. |
| Title | Molecular Biology of Kinetoplastid Parasites |
| Place, publisher, and date of publication | Norfolk : Caister Academic Press,c2018 |
| International Standard Book Number | 9781910190715 |
| 797 2# - LOCAL ADDED ENTRY--CORPORATE NAME (RLIN) | |
| Corporate name or jurisdiction name as entry element | ProQuest (Firm) |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://ebookcentral.proquest.com/lib/orpp/detail.action?docID=5897802">https://ebookcentral.proquest.com/lib/orpp/detail.action?docID=5897802</a> |
| Public note | Click to View |
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