Physicochemical Principles of Pharmacy : (Record no. 107492)
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| 000 -LEADER | |
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| fixed length control field | 11285nam a22005053i 4500 |
| 001 - CONTROL NUMBER | |
| control field | EBC4439013 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MiAaPQ |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20240729130338.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS | |
| fixed length control field | m o d | |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | cr cnu|||||||| |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 240724s2015 xx o ||||0 eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9780857112590 |
| Qualifying information | (electronic bk.) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| Canceled/invalid ISBN | 9780857111746 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (MiAaPQ)EBC4439013 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (Au-PeEL)EBL4439013 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (CaPaEBR)ebr11203366 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (OCoLC)947222597 |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | MiAaPQ |
| Language of cataloging | eng |
| Description conventions | rda |
| -- | pn |
| Transcribing agency | MiAaPQ |
| Modifying agency | MiAaPQ |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER | |
| Classification number | RS403 -- .F567 2016eb |
| 082 0# - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 615.19 |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Florence, Alexander T. |
| 245 10 - TITLE STATEMENT | |
| Title | Physicochemical Principles of Pharmacy : |
| Remainder of title | In Manufacture, Formulation and Clinical Use. |
| 250 ## - EDITION STATEMENT | |
| Edition statement | 6th ed. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | London : |
| Name of producer, publisher, distributor, manufacturer | Pharmaceutical Press, |
| Date of production, publication, distribution, manufacture, or copyright notice | 2015. |
| 264 #4 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | ©2015. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 1 online resource (665 pages) |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Content type code | txt |
| Source | rdacontent |
| 337 ## - MEDIA TYPE | |
| Media type term | computer |
| Media type code | c |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | online resource |
| Carrier type code | cr |
| Source | rdacarrier |
| 505 0# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Intro -- Contents -- Preface -- About the authors -- Introduction -- Physical chemistry and pharmacy -- The clinical relevance of physical pharmacy: clinical pharmaceutics -- Adjuvants or excipients -- Arrangement of the book -- Objectives -- 'Reading' structures and formulae -- Chemical structures -- Physical equations -- 1 Solids -- 1.1 Classification of solids -- 1.2 Crystalline solids: structure and properties -- 1.2.1 Crystal structure -- Miller indices -- 1.2.2 Crystal form -- Crystallisation and factors affecting crystal form2 -- Precipitation -- Habit modification -- 1.2.3 Polymorphism4 -- Pharmaceutical implications of polymorphism -- Transformations -- Analytical issues -- Consequences -- 1.2.4 Multicomponent crystals -- Crystal hydrates and solvates -- Pharmaceutical consequences of solvate formation -- Cocrystals -- 1.3 Amorphous solids -- 1.4 Dissolution of solid drugs -- 1.5 Biopharmaceutical importance of particle size -- 1.6 Wetting of powders -- 1.6.1 Contact angle and wettability of solid surfaces -- 1.6.2 Wettability of powders -- 1.7 Freeze drying -- 1.8 Solid-dosage forms: formulation and manufacture -- 1.8.1 Excipients -- Filler/diluent -- Disintegrants -- Binders -- Lubricants -- Glidants -- Flavouring agents and colourants -- 1.8.2 Powder flow -- 1.8.3 Particle size reduction -- 1.8.4 Powder mixing and demixing -- 1.8.5 Granulation -- Wet granulation -- Stage 1: Granule formation -- Extrusion/spheronisation techniques -- Bonding mechanisms in wet granulation -- Stage 2: Drying and milling -- Dry granulation -- Bonding mechanisms in dry granulation -- 1.8.6 Tablet manufacture -- Compression and compaction of powders -- The compression process -- Mechanisms of compression -- Tablet coating -- Film coating -- Film-coating formulations -- Solvent -- Polymer -- Plasticiser -- Colourant -- Surfactant -- Film-coating techniques. |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Drum or pan coating -- Fluidised-bed coating -- Dry coating -- Liquid-assisted coating -- Thermal adhesion -- Electrostatic coating -- 1.8.7 Capsule manufacture -- Chemical and physicochemical properties of gelatin -- Hard-capsule manufacture and filling -- Manufacture -- Filling of powder formulations -- Filling of pellets and tablets -- Filling of liquids and semisolids -- Soft gelatin (softgel) capsule manufacture and filling -- Manufacture and filling -- 1.9 Solid dispersions -- 1.9.1 Eutectic mixtures -- 1.9.2 Solid solutions -- 1.9.3 Eutectics and drug identification -- Summary -- References -- 2 Physicochemical properties of drugs in solution -- 2.1 Concentration units -- 2.1.1 Weight or volume concentration -- 2.1.2 Molarity and molality -- 2.1.3 Milliequivalents -- 2.1.4 Mole fraction -- 2.2 Thermodynamics: a brief introduction -- 2.2.1 Energy -- 2.2.2 Enthalpy -- 2.2.3 Entropy -- 2.2.4 Free energy -- 2.3 Activity and chemical potential -- 2.3.1 Activity and standard states -- 2.3.2 Activity of ionised drugs -- 2.3.3 Solvent activity -- Water activity and inhibition of bacterial growth -- Water activity and assessment of pharmaceutical products -- 2.3.4 Chemical potential -- Chemical potential of a component in solution -- 2.4 Osmotic properties of drug solutions -- 2.4.1 Osmotic pressure -- 2.4.2 Osmolality and osmolarity -- 2.4.3 Clinical relevance of osmotic effects -- Tonicity -- Volatile anaesthetics -- Rehydration solutions -- Oral rehydration therapy -- 2.4.4 Preparation of isotonic solutions -- 2.5 Ionisation of drugs in solution -- 2.5.1 Clinical relevance of drug ionisation -- 2.5.2 Dissociation of weakly acidic and basic drugs and their salts -- 2.5.3 The effect of pH on the ionisation of weakly acidic or basic drugs and their salts -- Weak acids -- Weak bases -- 2.5.4 Ionisation of amphoteric drugs -- Ordinary ampholytes. |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Zwitterionic ampholytes -- Large ΔpKa -- Small ΔpKa -- 2.5.5 Ionisation of polyprotic drugs -- 2.5.6 Microdissociation constants -- 2.5.7 pKa values of proteins -- 2.5.8 Calculation of the pH of drug solutions -- Weakly acidic drugs -- Weakly basic drugs -- Drug salts -- 2.5.9 Buffer solutions -- Buffer capacity -- Physiological regulation of acid-base balance -- Universal buffers -- 2.6 Diffusion of drugs in solution -- Summary -- References -- 3 Drug stability -- 3.1 The chemical decomposition of drugs -- 3.1.1 Hydrolysis -- Drugs susceptible to hydrolytic degradation -- Controlling drug hydrolysis in solution -- Optimisation of formulation -- Modification of chemical structure of drug -- 3.1.2 Oxidation4 -- Oxidation processes -- Drugs susceptible to oxidation -- Stabilisation against oxidation -- Antioxidants -- 3.1.3 Isomerisation -- 3.1.4 Photochemical decomposition10 -- Stabilisation against photochemical decomposition -- 3.1.5 Polymerisation -- 3.2 Kinetics of chemical decomposition in solution -- 3.2.1 Classifying reactions: the order of reaction -- 3.2.2 Zero-order reactions -- 3.2.3 First-order reactions -- 3.2.4 Second-order reactions -- 3.2.5 Third-order reactions -- 3.2.6 Determination of the order of reaction -- 3.2.7 Complex reactions -- Reversible reactions -- Parallel reactions -- Consecutive reactions -- 3.3 Solid-dosage forms: kinetics of chemical decomposition -- 3.3.1 Solids that decompose to give a solid and a gas -- 3.3.2 Solids that decompose to give a liquid and a gas -- 3.4 Factors influencing drug stability -- 3.4.1 Liquid-dosage forms -- pH -- Temperature -- Ionic strength -- Solvent effects -- Oxygen -- Light -- Surfactants -- 3.4.2 Semisolid-dosage forms -- 3.4.3 Solid-dosage forms -- Moisture -- Excipients -- Temperature -- Light and oxygen -- 3.5 Stability testing and prediction of shelf-life. |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | 3.5.1 Effect of temperature on stability -- Suspensions -- Solid state -- 3.5.2 Other environmental factors affecting stability -- Light -- Oxygen -- Moisture content -- 3.5.3 Protocol for stability testing -- Drug substances -- Drug product -- Summary -- Some final points on the stability of drugs -- References -- 4 The solubility of drugs -- 4.1 Definitions -- 4.1.1 Expressions of solubility -- 4.2 Factors influencing solubility -- 4.2.1 Structural features and aqueous solubility -- Size and shape -- Melting point and boiling point -- Substituents -- Steroid solubility -- 4.2.2 Hydration and solvation -- Hydration of non-electrolytes -- Hydration of ionic species: water structure breakers and structure makers -- Hydration numbers -- Hydrophobic hydration -- The solubility of inorganic materials in water -- 4.2.3 The effect of simple additives on solubility -- Solubility products -- Common ion effect -- Salting in and salting out -- 4.2.4 The effect of pH on the solubility of ionisable drugs -- Acidic drugs -- Basic drugs -- Amphoteric drugs -- Rule of thumb -- 4.3 Measurement of solubility -- 4.4 The solubility parameter -- 4.4.1 Solubility parameters and biological processes -- 4.5 Solubility in mixed solvents: use of cosolvents -- Outline placeholder -- Room-temperature ionic liquids -- 4.6 Cyclodextrins as solubilising agents -- Outline placeholder -- Calixarenes -- 4.7 Solubility problems in formulation -- 4.7.1 Mixtures of acidic and basic compounds -- 4.7.2 Choice of drug salt to optimise solubility -- 4.7.3 Drug solubility and biological activity -- 4.8 Partitioning -- 4.8.1 The partition coefficient -- 4.8.2 Free energies of transfer -- 4.8.3 Octanol as a non-aqueous phase -- 4.9 Biological activity and partition coefficients: thermodynamic activity and Ferguson's principle -- 4.10 Using log P. |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | 4.10.1 The relationship between lipophilicity and behaviour of tetracyclines -- 4.10.2 Sorption -- 4.10.3 A chromatographic model for the biophase -- 4.10.4 Calculating log& -- thinsp -- P from molecular structures -- 4.10.5 Drug distribution into human milk -- Summary -- References -- 5 Surfactants -- 5.1 Amphipathic compounds -- 5.2 Surface and interfacial properties of surfactants -- 5.2.1 Effects of amphiphiles on surface and interfacial tension -- 5.2.2 Change of surface tension with surfactant concentration: the critical micelle concentration -- 5.2.3 Gibbs adsorption equation -- Application of the Gibbs equation to surfactant solutions -- 5.2.4 The influence of the surfactant structure on surface activity -- 5.2.5 Surface activity of drugs -- 5.2.6 Insoluble monolayers -- Experimental study of insoluble films -- Monolayer states -- Solid or condensed monolayers -- Gaseous monolayers -- Expanded monolayers -- Factors influencing monolayer state -- Visualisation of monolayer structures -- Polymer monolayers -- Lung surfactant monolayers -- 5.2.7 Pharmaceutical applications of surface film studies -- Study of polymers used as packaging materials and film coatings -- Cell membrane models -- 5.2.8 Adsorption at the solid-liquid interface -- Adsorption isotherms -- Langmuir equation -- Freundlich equation -- Factors affecting adsorption -- Solubility of the adsorbate -- pH -- Nature of the adsorbent -- Temperature -- Some medical and pharmaceutical applications and consequences of adsorption -- Adsorption of poisons/toxins -- Taste masking -- Haemoperfusion -- Adsorption in drug formulation -- 5.3 Micellisation -- 5.3.1 Water structure and hydrophobic bonding -- 5.3.2 Theories of micelle formation -- 5.3.3 Micellar structure -- Critical packing parameter -- Ionic micelles -- Non-ionic micelles. |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | 5.3.4 Factors affecting the critical micelle concentration and micellar size. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | This established textbook covers every aspect of drug properties from the design of dosage forms to their delivery by all routes to sites of action in the body. |
| 588 ## - SOURCE OF DESCRIPTION NOTE | |
| Source of description note | Description based on publisher supplied metadata and other sources. |
| 590 ## - LOCAL NOTE (RLIN) | |
| Local note | Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Pharmaceutical chemistry. |
| 655 #4 - INDEX TERM--GENRE/FORM | |
| Genre/form data or focus term | Electronic books. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Attwood, David. |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Relationship information | Print version: |
| Main entry heading | Florence, Alexander T. |
| Title | Physicochemical Principles of Pharmacy |
| Place, publisher, and date of publication | London : Pharmaceutical Press,c2015 |
| International Standard Book Number | 9780857111746 |
| 797 2# - LOCAL ADDED ENTRY--CORPORATE NAME (RLIN) | |
| Corporate name or jurisdiction name as entry element | ProQuest (Firm) |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://ebookcentral.proquest.com/lib/orpp/detail.action?docID=4439013">https://ebookcentral.proquest.com/lib/orpp/detail.action?docID=4439013</a> |
| Public note | Click to View |
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