Osteoimmunology : (Record no. 100608)
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| fixed length control field | 11234nam a22005653i 4500 |
| 001 - CONTROL NUMBER | |
| control field | EBC4003868 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MiAaPQ |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20240729130020.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS | |
| fixed length control field | m o d | |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | cr cnu|||||||| |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 240724s2015 xx o ||||0 eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9780128006276 |
| Qualifying information | (electronic bk.) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| Canceled/invalid ISBN | 9780128005712 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (MiAaPQ)EBC4003868 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (Au-PeEL)EBL4003868 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (CaPaEBR)ebr11096467 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (CaONFJC)MIL277000 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (OCoLC)927490178 |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | MiAaPQ |
| Language of cataloging | eng |
| Description conventions | rda |
| -- | pn |
| Transcribing agency | MiAaPQ |
| Modifying agency | MiAaPQ |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER | |
| Classification number | QP88.2 -- .O884 2016eb |
| 082 0# - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 616.07/9 |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Lorenzo, Joseph. |
| 245 10 - TITLE STATEMENT | |
| Title | Osteoimmunology : |
| Remainder of title | Interactions of the Immune and Skeletal Systems. |
| 250 ## - EDITION STATEMENT | |
| Edition statement | 2nd ed. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | San Diego : |
| Name of producer, publisher, distributor, manufacturer | Elsevier Science & Technology, |
| Date of production, publication, distribution, manufacture, or copyright notice | 2015. |
| 264 #4 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | ©2016. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 1 online resource (380 pages) |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Content type code | txt |
| Source | rdacontent |
| 337 ## - MEDIA TYPE | |
| Media type term | computer |
| Media type code | c |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | online resource |
| Carrier type code | cr |
| Source | rdacarrier |
| 505 0# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Cover -- Title Page -- Copyright Page -- Contents -- List of Contributors -- Foreword -- Preface -- Chapter 1 - Overview: The Developing Field of Osteoimmunology -- References -- Chapter 2 - The Origins of the Osteoclast -- First descriptions of the osteoclast -- Early controversies: are osteoclasts capable of bone resorption? -- Early controversies: hematopoietic or mesenchymal origin of the osteoclast? -- Osteoclast: a hematopoietic cell -- Osteoclasts: cells of the myeloid lineage -- Advancing the field: culturing osteoclasts in vitro -- Identification of RANKL and OPG -- Defining osteoclast precursors within myeloid cell development -- Heterogeneity among osteoclasts -- Origins of the osteoclast through the lens of evolution -- Osteoclast-Like Activity in Invertebrates -- Osteoclasts in Fish -- Conclusions -- Acknowledgments -- References -- Chapter 3 - Trafficking of Osteoclast Precursors -- Introduction -- A century-long search for the identity of osteoclast precursors -- Intravital two-photon imaging of bone tissues -- Osteoclast precursors are motile and circulate throughout the body -- Guidance cues sensed by osteoclast precursors in bone marrow -- S1P-dependent migratory control of osteoclast precursors -- Differences between osteoclast precursor and mature osteoclast migration mechanisms -- Control of osteoclast migration and function by Rho GTPases -- Role of integrins in osteoclast precursor migration -- Control of osteoclast precursor differentiation by GPCR-mediated inhibition of cell migration -- Unanswered questions in osteoclast precursor trafficking and differentiation -- References -- Chapter 4 - Osteoclast Biology: Regulation of Formation and Function -- Introduction -- RANKL and RANK: an osteoclastogenic cytokine and its receptor -- TRAF6: the multifunctional signaling molecule activated by RANK. |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | What happens downstream of TRAF6? -- The role of NF-kB in osteoclast differentiation -- The critical role of AP-1 transcription factors -- MAPKs activated by RANKL -- NFATc1 is a master transcription factor of osteoclast differentiation -- Autoamplification of NFATc1 and its epigenetic regulation -- Inhibition of NFATc1 induction -- Transcriptional control governed by NFATc1 -- Costimulatory receptor signals for RANK: FcRg and DAP12 -- The ligands for the costimulatory receptors -- Importance of ITAM costimulatory signals in humans: Nasu-Hakola disease -- Additional costimulatory signals involved in osteoclastogenesis -- Receptors signaling through DAP12 -- The inhibitory signals for costimulatory signals -- Src family kinases: activation of ITAM signaling -- Syk kinase: downstream of DAP12/FcRg? -- PLCg2: enzyme and adaptor molecule -- Tec kinases: integrating RANK and ITAM signaling -- Negative regulatory role of DAP12 -- M-CSF and c-Fms: a road to proliferation and survival -- M-CSF signaling -- Erk, PI3K, and c-Fos signaling -- The osteoclast's job: bone resorption -- Osteoclast cytoskeleton: the podosomes and the sealing zone -- Osteoclast cytoskeleton: the microtubules and the sealing zone -- Osteoclast functional structure: the ruffled border -- Osteoclast and bone matrix: role of αvβ3 integrin -- Integrin-associated proteins -- M-CSF and the osteoclast cytoskeleton -- Coupling factors released in osteoclastic bone resorption -- Stimulation of bone formation by clastokines -- Inhibition of bone formation by clastokines -- Coupling by cell-cell interaction between osteoclasts and osteoblasts -- Conclusions -- References -- Chapter 5 - Osteoimmunology and the Osteoblast -- Advantages of immune-osteoblast interaction -- Immune-osteoblast interaction in fracture repair -- Immune Cells Set the Order and Tempo of Fracture Repair. |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Dual role for TNF-α -- TNF is an inhibitor of Wnt signaling -- Coupling of skeletal homeostasis with innate and acquired immunity -- Normal Bone Remodeling -- Osteoblast support of hematopoiesis -- Osteoblast support of B cell differentiation -- Osteoblasts support hematopoietic stem cells -- Conclusions -- References -- Chapter 6 - The Variety of Osteocyte Function -- Introduction -- The osteocyte network -- New tools to study osteocyte function -- Osteocytes and bone remodeling -- Osteocytes and mineral homeostasis -- Osteocytes as mechanosensors -- Osteocytes and hematopoiesis -- Conclusions -- References -- Chapter 7 - Bone Marrow Hematopoietic Niches -- Introduction -- Hematopoiesis occurs within the bone marrow and is closely linked to skeletal development -- A role for the osteoblast lineage in supporting hematopoietic stem cells -- A perivascular niche for HSCs involves mesenchymal progenitors -- Signaling pathways implicated in microenvironment-HSC communication -- CXCL12/CXCR4 -- SCF -- Angiopoietin-1/Tie2 -- Thrombopoietin/Mpl -- Osteopontin -- Calcium-Sensing Receptor -- N-Cadherin -- Parathyroid Hormone Receptor Signaling -- Notch Signaling -- Wnt Signaling -- Prostaglandin E2 -- TGFβ1 -- Perivascular osteoblast precursors support hematopoiesis -- Other components of the hematopoietic niche -- Macrophages -- Endothelial Cells -- Sympathetic Neurons -- Adipocytes -- Clinical implications -- HSC Engraftment After Transplantation -- Microenvironment and Disease -- Effect of Aging-Related Bone Loss on Hematopoiesis -- The bone marrow HSC microenvironment is complex -- References -- Chapter 8 - RANK and RANKL of Bones, T Cells, and the Mammary Glands -- RANK and RANKL in bone -- Downstream signaling of RANK/RANKL -- Rank/Rankl mutations in human patients -- Osteoimmunology -- RANK and RANKL in the organogenesis of the immune system. |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Immunotolerance -- RANK/RANKL and metastases -- RANK/RANKL and the mammary gland -- RANK and RANKL and their function in mammary stem cell biology -- Breast cancer -- Is there even more? -- Denosumab, a rational treatment for bone loss -- Conclusions -- References -- Chapter 9 - The Effects of Immune Cell Products (Cytokines and Hematopoietic Cell Growth Factors) on Bone Cells -- Receptor activator of nuclear factor-kB ligand (RANKL), receptor activator of nuclear factor-kB (RANK) and osteoprotegerin ... -- Colony-stimulating factor-1 -- Additional colony stimulating factors -- Interleukin-1 -- Tumor necrosis factor -- Additional TNF superfamily members -- Fas-Ligand -- TNF-Related Apoptosis Inducing Ligand (TRAIL) -- CD40-ligand -- Interleukin-6 -- Additional interleukin-6 family members -- Interleukin-11 -- Leukemia Inhibitory Factor -- Oncostatin M -- Interleukin-7 -- Interleukin-8 and other chemokines -- Interleukin-8 -- CCL2 -- CCL3 -- CCL9 -- CXCL12 and CXCR4 -- CX3CR1 -- CCR1 -- CCR2 -- Interleukin-10 -- Interleukin 12 -- Interleukin 15 -- Interleukin 17, Interleukin 23, and Interleukin 27 -- Interleukin 18 and interleukin 33 -- Interferons -- Additional cytokine -- Conclusions -- References -- Chapter 10 - Coupling: The Influences of Immune and Bone Cells -- Introduction: bone remodeling and the concept of coupling -- Modeling and remodeling in anabolic therapy for the skeleton -- Osteoclast-derived factors that promote osteoblast differentiation -- Matrix-Derived Signals Released During Resorption -- Factors Secreted by the Osteoclast That Promote Bone Formation -- Do Macrophages Also Stimulate Bone Formation in the BMU? -- Other Contributions of Macrophages to Bone Formation in Remodeling -- Proteins Expressed on the Osteoclast Cell Membrane That Stimulate Osteoblast Differentiation. |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Summary of Section II: Multiple Cell Types Promote Bone Formation During the Remodeling Process -- What is the target cell of osteoclast-derived factors that may promote bone formation? -- How do osteocytes contribute to coupling? -- Promotion of bone formation in the BMU during the reversal phase -- The influences of T and B lymphocytes on the coupling process -- Signals between the bone surface and the vasculature -- Isolation of the remodeling site by the bone remodeling canopy -- Conclusions -- References -- Chapter 11 - The Role of the Immune System in the Development of Osteoporosis and Fracture Risk -- Introduction -- Connections between bone and the immune system -- Bone remodeling -- Periarticular bone structure and bone loss in inflammatory arthritis -- Bone involvement in rheumatic diseases -- Bone Changes in Rheumatic Diseases -- Bone Erosions -- Bone Marrow Edema (BME) -- Local Peri-Inflammatory Bone Changes -- Generalized Bone Changes -- Fracture Healing -- Methods for quantifying changes in bone in inflammatory rheumatic diseases -- CR -- High-resolution CR -- Radiogrammetry and DXR -- Photonabsorptiometry -- Magnetic resonance imaging (MRI) -- Quantitative ultrasound (QUS) of the bone -- Musculoskeletal ultrasound (MSUS) -- Quantitative computed tomography (QCT) -- High resolution peripheral quantitative computed tomography (HRpQCT) -- Bone and inflammation markers -- Clinical risk factors for low BMD, falls, and fractures -- From fracture risk evaluation to fracture prevention: a 5-step plan -- Case Finding -- Risk Evaluation -- Clinical Risk Factors -- Measurements and Imaging Tools -- Biomarkers -- Risk of falls in RA -- Differential diagnosis -- Fracture prevention in inflammatory joint diseases -- General Measures -- Calcium and Vitamin D -- Treatment of Glucocorticoid Osteoporosis. |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Antirheumatic Drugs and the Effect on Bone Metabolism and BMD. |
| 588 ## - SOURCE OF DESCRIPTION NOTE | |
| Source of description note | Description based on publisher supplied metadata and other sources. |
| 590 ## - LOCAL NOTE (RLIN) | |
| Local note | Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Bone -- Physiology. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Immunology. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Musculoskeletal system. |
| 655 #4 - INDEX TERM--GENRE/FORM | |
| Genre/form data or focus term | Electronic books. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Horowitz, Mark. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Choi, Yongwon. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Takayanagi, Hiroshi. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Schett, Georg. |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Relationship information | Print version: |
| Main entry heading | Lorenzo, Joseph |
| Title | Osteoimmunology |
| Place, publisher, and date of publication | San Diego : Elsevier Science & Technology,c2015 |
| International Standard Book Number | 9780128005712 |
| 797 2# - LOCAL ADDED ENTRY--CORPORATE NAME (RLIN) | |
| Corporate name or jurisdiction name as entry element | ProQuest (Firm) |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://ebookcentral.proquest.com/lib/orpp/detail.action?docID=4003868">https://ebookcentral.proquest.com/lib/orpp/detail.action?docID=4003868</a> |
| Public note | Click to View |
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