Advances in Cardiovascular Research. Volume 1.
Schmitt, Lukas.
Advances in Cardiovascular Research. Volume 1. - 1st ed. - 1 online resource (480 pages) - Advances in Cardiovascular Research ; v.1 . - Advances in Cardiovascular Research .
Intro -- ADVANCES IN CARDIOVASCULAR RESEARCH, VOLUME 1 -- ADVANCES IN CARDIOVASCULAR RESEARCH, VOLUME 1 -- Contents -- Preface -- Chapter I The Mitral Valve: Development, Structure, Pathology & -- Tissue Engineering -- Abstract -- I. Development of the Mitral Valve Apparatus -- II. Histological Anatomy of the Mitral Valve -- III. Surface Topographical and Ultrastructural Anatomy of the Mitral Valve -- III.I. Surface Topography of the Mitral Valve -- III.II. Ultrastructure of the Mitral Valve -- III.II.I. Endocardial endothelium (EE) -- III.II.II. Valvar interstitial cells (VIC) -- III.II.III. Extracellular matrix (ECM) -- III.II.IV. Neural elements -- IV. Myxomatous Mitral Valve Disease (Canine Model) -- IV.I. Clinical Features and Natural Disease Progression -- IV.II. Pathology of Myxomatous Mitral Valve Disease -- IV.III. Pathogenesis and Pathophysiology of Myxomatous Mitral Valve Disease -- V. Mitral Valve Regeneration & -- Tissue Engineering -- V.I. Cell Sourcing for Mitral Valve Tissue Engineering -- V.II. Scaffold Development for Mitral Valve Tissue Engineering -- V.III. Bioreactor Development for Mitral Valve Tissue Engineering -- V.IV. Challenges in the Field of Mitral Valve Tissue Engineering -- References -- Chapter II Review of Treatment of Ventricular Fibrillation -- Abstract -- Cardiopulmonary Resuscitation -- Drug Therapy of Ventricular Fibrillation -- Introduction -- Amiodarone -- Sotalol -- Non anti-arrhythmic drugs that reduce risk of SCD -- Angiotensin Converting Enzyme (ACE) Inhibitors -- Aldosterone antagonists -- Statins -- Fish Oils -- Beta blockers -- Use of β blockers post myocardial infarction -- Use of β blockers in heart failure -- CIBIS I -- CIBIS II -- MERIT HF -- US Carvedilol Heart Failure Study -- COPERNICUS -- COMET (& -- BEST) Trial -- Automated External Defibrillators &. Public Access Defibrillation -- Introduction -- The Modern AED -- Public Access Defibrillation (PAD) -- Forms of PAD -- Site Specific -- Airline studies -- Airport studies -- Casino studies -- Community Based -- Public Access Defibrillation Trial -- Hybrid approaches -- Recent CPR vs CPR & -- AED Meta-analysis -- Cost effectiveness of public access defibrillation in public places -- Home Programmes -- Early AED at Home trials -- Home AED Trial (HAT) -- Summary of public access defibrillation -- The Implantable Cardioverter-Defibrillator -- Introduction -- Primary Prevention -- MADIT I -- MUSTT -- MADIT II -- DINAMIT -- CABG-PATCH -- DEFINITE -- ScD-HeFT -- META-ANALYSIS -- Summary -- Secondary Prevention -- Introduction -- Early and DUTCH Trials -- CASH -- CIDS -- AVID -- META-ANALYSIS -- Summary -- Cost effectiveness of ICDs -- Summing up and Future Directions -- VF ABLATION -- Abbreviations -- References -- Chapter III A Historical View of Advances in the Resuscitation of Patients in Ventricular Fibrillation from the Perspective of Emergency Medical Services -- Abstract -- Introduction -- A Brief History of the Development of Modern Day Cardiopulmonary Resuscitation and Defibrillation -- Cardiovascular Disease and Sudden Cardiac Death: The Demographics and Survival Rates of Patient in VF -- Mechanism of Sudden Cardiac Death and Ventricular Fibrillation: The Arrhythmogenicity of Myocardial Ischaemia -- The Management of Out-of-Hospital Cardiac Arrest: Evolution of Emergency Medical Services -- The Evolution of Advanced Life Support -- Establishment of the International Liason Committee on Resuscitation to Develop a Concerted International Approach -- The 2005 ILCOR Guidelines for Resuscitation: CPR before Defirbillation in VF Cardiac Arrest -- Conclusion: A Look to the Future -- References. Chapter IV The Ambiguous Role of Epinephrine in Ventricular Fibrillation -- Abstract -- Introduction -- Epinephrine in CPR -- Epinephrine in the Human Organism -- Adrenergic Receptor Classification -- Epinephrine's Actions -- Pathophysiology of CA -- Reperfusion Injury & -- Post-Resuscitation Myocardial Dysfunction -- Three-Phase Ventricular Fibrillation Model -- Adverse Effects of Epinephrine -- Coronary Vasoconstriction -- Increase in Myocardial Oxygen Consumption -- Increased Ventricular Ectopic Activity -- Pulmonary Ventilation Perfusion Defects -- Increase in Defibrillation Energy Requirements -- Platelet Aggregation -- Catecholamine Oxidation -- Mast Cell Degranulation -- Increase of the Severity of Post-Resuscitation Myocardial Dysfunction -- Factors Influencing Epinephrine's Effectiveness -- Epinephrine's Activity in VF Setting -- Receptor Desensitization -- CPR Quality -- Time to Drug Administration -- Epinephrine's Dose -- Epinephrine in CPR Research -- Epinephrine vs Placebo -- Alternative Pharmacologic Agents -- Vasopressin -- Vasopressin vs Epinephrine in Animal Studies -- Vasopressin vs Epinephrine in Clinical Studies -- Vasopressin Combined with Epinephrine vs Epinephrine Alone -- Adrenergic Agents -- Selective α 2-adrenoreceptor Agonists -- α-Methylnorepinephrine (α -ΜΝΕ) -- Norepinephrine -- Epinephrine and β-Blockers -- Epinephrine Combined with Vasopressin and Nitroglycerin -- Epinephrine Combined with Cariporide -- Epinephrine Combined with Levosimendan -- Causes of Discrepancies between Laboratory and Clinical Trials in CPR -- Laboratory CPR and Manual CPR -- Time and Route of Epinephrine Administration -- Subjects' Health Status -- End Points in CPR Trials -- Conclusion -- References -- Chapter V Defibrillation: Mechanisms, Waveforms, Energy Levels, Transthoracic Impedance and Automated External Defibrillators. Abstract -- Definition and Mechanisms -- Waveforms and Energy Levels -- One Versus 3 Shock Protocol -- Transthoracic Impedance and Optimal Defibrillation -- Electrode Position -- Automated External Defibrillators -- Conclusion -- References -- Chapter VI Acute Kidney Injury after Coronary Artery Bypass -- Abstract -- Introduction -- Incidence and Prognosis of Acute Kidney Injuries after Bypass Surgery -- Risk Factors Associated with Acute Kidney Injury -- A. The Patient -- B. Surgical Procedure -- C. CPB -- D. Post-Operative Period -- Mechanisms Leading to Acute Kidney Injury -- A. Specificity of Renal Vascularisation -- B. Hemodynamic Effects and Microcirculatory Disruption -- C. Systemic Inflammation and Ischemia-Reperfusion -- D. Embolism -- E. Toxicity -- Diagnosis of Acute Kidney Injury after Coronary Artery Bypass -- How Can We Prevent Acute Kidney Injury after Coronary Artery Bypass? -- A. General Measures -- B. Pharmacological Interventions -- C. Management of CPB -- Conclusion -- References -- Chapter VII Rheumatic Valvulopathy: Current Understanding of Pathogenesis and Perspective of Immunobiological Treatments -- Abstract -- Introduction -- Epidemiology and Etiologic Agent -- Genetic Susceptibility and Pathogenesis -- Diagnosis and Clinical Manifestations -- Carditis -- Arthritis -- Erythema Marginatum -- Subcutaneous Nodules -- Chorea -- Other Manifestations -- Laboratory Investigation -- Evidence of a Recent Streptococcal Infection -- Inflammatory Markers -- Synovial Fluid Analysis -- Differential Diagnosis -- Treatment -- Treatment of the Clinical Manifestations -- Surgical Treatment -- Vaccine -- Future Perspectives -- References -- Chapter VIII Microstructure of the Aortic Valve: Implications for Valvular Mechanics and Function -- Abstract -- Introduction -- Fibrosa -- Ventricularis -- Spongiosa -- Endothelium. Future Directions -- Determining the Effect of the Hydrated Nature of the Spongiosa on Leaflet Mechanical Behavior in Tension and Compression -- Characterizing the Composition, Density, and Location of Interconnecting Fibers in the Spongiosa -- Determining the Effect of the Layered Structure on Diffusion through the Aortic Valve -- Determining the Effect of the Layered Structure on VIC Phenotype and Function -- Determining the Influence of GAGs and PGs on Matrix Organization and Mechanical Properties -- Conclusion -- References -- Chapter IX Morphological Aspects in Analysis of Postoperative Remodeling of Left Ventricle in Patients with Icmp -- Abstract -- Introduction -- Materials and Methods -- Results and Discussion -- Conclusion -- References -- Chapter X Functional and Ischemic Mitral Regurgitation -- Abstract -- Introduction -- Ischemic Mitral Regurgitation -- Etiology and Epidemiology -- Pathophysiology and Diagnostic Assessment -- Experimental IMR -- Inferior and anterior infarction -- Annular dilatation -- Left ventricular dyssynchrony -- Dynamic IMR -- Echocardiographic measurements -- Surgical Technique -- Annuloplasty -- Procedures on the mitral leaflets -- Posterior mitral valve restoration -- Anterior leaflet augmentation -- Posterior leaflet extension -- Edge-to-edge -- Procedures on the subvalvular apparatus and papillary muscles -- Chordal cutting -- Papillary muscle sling -- Posterior papillary muscle relocation -- Ring plus String suture -- Procedures at the ventricular level -- Papillary muscle approximation - imbrication -- Left ventricular infarct transversal plication -- Left ventricular infarct longitudinal plication -- Coapsys and CorCap devices -- Minimally invasive and transcatheter procedures -- Current Attitudes and Indications for Surgery -- Conclusion -- References. Chapter XI Confounding of Genetic and Environmental Factors in Pregnancy-Induced Hypertension.
9781612092133
Cardiovascular system -- Diseases.
Internal medicine.
Electronic books.
RC667 -- .A35 2010eb
362.196/10072
Advances in Cardiovascular Research. Volume 1. - 1st ed. - 1 online resource (480 pages) - Advances in Cardiovascular Research ; v.1 . - Advances in Cardiovascular Research .
Intro -- ADVANCES IN CARDIOVASCULAR RESEARCH, VOLUME 1 -- ADVANCES IN CARDIOVASCULAR RESEARCH, VOLUME 1 -- Contents -- Preface -- Chapter I The Mitral Valve: Development, Structure, Pathology & -- Tissue Engineering -- Abstract -- I. Development of the Mitral Valve Apparatus -- II. Histological Anatomy of the Mitral Valve -- III. Surface Topographical and Ultrastructural Anatomy of the Mitral Valve -- III.I. Surface Topography of the Mitral Valve -- III.II. Ultrastructure of the Mitral Valve -- III.II.I. Endocardial endothelium (EE) -- III.II.II. Valvar interstitial cells (VIC) -- III.II.III. Extracellular matrix (ECM) -- III.II.IV. Neural elements -- IV. Myxomatous Mitral Valve Disease (Canine Model) -- IV.I. Clinical Features and Natural Disease Progression -- IV.II. Pathology of Myxomatous Mitral Valve Disease -- IV.III. Pathogenesis and Pathophysiology of Myxomatous Mitral Valve Disease -- V. Mitral Valve Regeneration & -- Tissue Engineering -- V.I. Cell Sourcing for Mitral Valve Tissue Engineering -- V.II. Scaffold Development for Mitral Valve Tissue Engineering -- V.III. Bioreactor Development for Mitral Valve Tissue Engineering -- V.IV. Challenges in the Field of Mitral Valve Tissue Engineering -- References -- Chapter II Review of Treatment of Ventricular Fibrillation -- Abstract -- Cardiopulmonary Resuscitation -- Drug Therapy of Ventricular Fibrillation -- Introduction -- Amiodarone -- Sotalol -- Non anti-arrhythmic drugs that reduce risk of SCD -- Angiotensin Converting Enzyme (ACE) Inhibitors -- Aldosterone antagonists -- Statins -- Fish Oils -- Beta blockers -- Use of β blockers post myocardial infarction -- Use of β blockers in heart failure -- CIBIS I -- CIBIS II -- MERIT HF -- US Carvedilol Heart Failure Study -- COPERNICUS -- COMET (& -- BEST) Trial -- Automated External Defibrillators &. Public Access Defibrillation -- Introduction -- The Modern AED -- Public Access Defibrillation (PAD) -- Forms of PAD -- Site Specific -- Airline studies -- Airport studies -- Casino studies -- Community Based -- Public Access Defibrillation Trial -- Hybrid approaches -- Recent CPR vs CPR & -- AED Meta-analysis -- Cost effectiveness of public access defibrillation in public places -- Home Programmes -- Early AED at Home trials -- Home AED Trial (HAT) -- Summary of public access defibrillation -- The Implantable Cardioverter-Defibrillator -- Introduction -- Primary Prevention -- MADIT I -- MUSTT -- MADIT II -- DINAMIT -- CABG-PATCH -- DEFINITE -- ScD-HeFT -- META-ANALYSIS -- Summary -- Secondary Prevention -- Introduction -- Early and DUTCH Trials -- CASH -- CIDS -- AVID -- META-ANALYSIS -- Summary -- Cost effectiveness of ICDs -- Summing up and Future Directions -- VF ABLATION -- Abbreviations -- References -- Chapter III A Historical View of Advances in the Resuscitation of Patients in Ventricular Fibrillation from the Perspective of Emergency Medical Services -- Abstract -- Introduction -- A Brief History of the Development of Modern Day Cardiopulmonary Resuscitation and Defibrillation -- Cardiovascular Disease and Sudden Cardiac Death: The Demographics and Survival Rates of Patient in VF -- Mechanism of Sudden Cardiac Death and Ventricular Fibrillation: The Arrhythmogenicity of Myocardial Ischaemia -- The Management of Out-of-Hospital Cardiac Arrest: Evolution of Emergency Medical Services -- The Evolution of Advanced Life Support -- Establishment of the International Liason Committee on Resuscitation to Develop a Concerted International Approach -- The 2005 ILCOR Guidelines for Resuscitation: CPR before Defirbillation in VF Cardiac Arrest -- Conclusion: A Look to the Future -- References. Chapter IV The Ambiguous Role of Epinephrine in Ventricular Fibrillation -- Abstract -- Introduction -- Epinephrine in CPR -- Epinephrine in the Human Organism -- Adrenergic Receptor Classification -- Epinephrine's Actions -- Pathophysiology of CA -- Reperfusion Injury & -- Post-Resuscitation Myocardial Dysfunction -- Three-Phase Ventricular Fibrillation Model -- Adverse Effects of Epinephrine -- Coronary Vasoconstriction -- Increase in Myocardial Oxygen Consumption -- Increased Ventricular Ectopic Activity -- Pulmonary Ventilation Perfusion Defects -- Increase in Defibrillation Energy Requirements -- Platelet Aggregation -- Catecholamine Oxidation -- Mast Cell Degranulation -- Increase of the Severity of Post-Resuscitation Myocardial Dysfunction -- Factors Influencing Epinephrine's Effectiveness -- Epinephrine's Activity in VF Setting -- Receptor Desensitization -- CPR Quality -- Time to Drug Administration -- Epinephrine's Dose -- Epinephrine in CPR Research -- Epinephrine vs Placebo -- Alternative Pharmacologic Agents -- Vasopressin -- Vasopressin vs Epinephrine in Animal Studies -- Vasopressin vs Epinephrine in Clinical Studies -- Vasopressin Combined with Epinephrine vs Epinephrine Alone -- Adrenergic Agents -- Selective α 2-adrenoreceptor Agonists -- α-Methylnorepinephrine (α -ΜΝΕ) -- Norepinephrine -- Epinephrine and β-Blockers -- Epinephrine Combined with Vasopressin and Nitroglycerin -- Epinephrine Combined with Cariporide -- Epinephrine Combined with Levosimendan -- Causes of Discrepancies between Laboratory and Clinical Trials in CPR -- Laboratory CPR and Manual CPR -- Time and Route of Epinephrine Administration -- Subjects' Health Status -- End Points in CPR Trials -- Conclusion -- References -- Chapter V Defibrillation: Mechanisms, Waveforms, Energy Levels, Transthoracic Impedance and Automated External Defibrillators. Abstract -- Definition and Mechanisms -- Waveforms and Energy Levels -- One Versus 3 Shock Protocol -- Transthoracic Impedance and Optimal Defibrillation -- Electrode Position -- Automated External Defibrillators -- Conclusion -- References -- Chapter VI Acute Kidney Injury after Coronary Artery Bypass -- Abstract -- Introduction -- Incidence and Prognosis of Acute Kidney Injuries after Bypass Surgery -- Risk Factors Associated with Acute Kidney Injury -- A. The Patient -- B. Surgical Procedure -- C. CPB -- D. Post-Operative Period -- Mechanisms Leading to Acute Kidney Injury -- A. Specificity of Renal Vascularisation -- B. Hemodynamic Effects and Microcirculatory Disruption -- C. Systemic Inflammation and Ischemia-Reperfusion -- D. Embolism -- E. Toxicity -- Diagnosis of Acute Kidney Injury after Coronary Artery Bypass -- How Can We Prevent Acute Kidney Injury after Coronary Artery Bypass? -- A. General Measures -- B. Pharmacological Interventions -- C. Management of CPB -- Conclusion -- References -- Chapter VII Rheumatic Valvulopathy: Current Understanding of Pathogenesis and Perspective of Immunobiological Treatments -- Abstract -- Introduction -- Epidemiology and Etiologic Agent -- Genetic Susceptibility and Pathogenesis -- Diagnosis and Clinical Manifestations -- Carditis -- Arthritis -- Erythema Marginatum -- Subcutaneous Nodules -- Chorea -- Other Manifestations -- Laboratory Investigation -- Evidence of a Recent Streptococcal Infection -- Inflammatory Markers -- Synovial Fluid Analysis -- Differential Diagnosis -- Treatment -- Treatment of the Clinical Manifestations -- Surgical Treatment -- Vaccine -- Future Perspectives -- References -- Chapter VIII Microstructure of the Aortic Valve: Implications for Valvular Mechanics and Function -- Abstract -- Introduction -- Fibrosa -- Ventricularis -- Spongiosa -- Endothelium. Future Directions -- Determining the Effect of the Hydrated Nature of the Spongiosa on Leaflet Mechanical Behavior in Tension and Compression -- Characterizing the Composition, Density, and Location of Interconnecting Fibers in the Spongiosa -- Determining the Effect of the Layered Structure on Diffusion through the Aortic Valve -- Determining the Effect of the Layered Structure on VIC Phenotype and Function -- Determining the Influence of GAGs and PGs on Matrix Organization and Mechanical Properties -- Conclusion -- References -- Chapter IX Morphological Aspects in Analysis of Postoperative Remodeling of Left Ventricle in Patients with Icmp -- Abstract -- Introduction -- Materials and Methods -- Results and Discussion -- Conclusion -- References -- Chapter X Functional and Ischemic Mitral Regurgitation -- Abstract -- Introduction -- Ischemic Mitral Regurgitation -- Etiology and Epidemiology -- Pathophysiology and Diagnostic Assessment -- Experimental IMR -- Inferior and anterior infarction -- Annular dilatation -- Left ventricular dyssynchrony -- Dynamic IMR -- Echocardiographic measurements -- Surgical Technique -- Annuloplasty -- Procedures on the mitral leaflets -- Posterior mitral valve restoration -- Anterior leaflet augmentation -- Posterior leaflet extension -- Edge-to-edge -- Procedures on the subvalvular apparatus and papillary muscles -- Chordal cutting -- Papillary muscle sling -- Posterior papillary muscle relocation -- Ring plus String suture -- Procedures at the ventricular level -- Papillary muscle approximation - imbrication -- Left ventricular infarct transversal plication -- Left ventricular infarct longitudinal plication -- Coapsys and CorCap devices -- Minimally invasive and transcatheter procedures -- Current Attitudes and Indications for Surgery -- Conclusion -- References. Chapter XI Confounding of Genetic and Environmental Factors in Pregnancy-Induced Hypertension.
9781612092133
Cardiovascular system -- Diseases.
Internal medicine.
Electronic books.
RC667 -- .A35 2010eb
362.196/10072