The GnRH Neuron and Its Control.
Herbison, Allan E.
The GnRH Neuron and Its Control. - 1st ed. - 1 online resource (536 pages) - Wiley-INF Masterclass in Neuroendocrinology Series . - Wiley-INF Masterclass in Neuroendocrinology Series .
Cover -- Title Page -- Copyright -- Contents -- List of Contributors -- Series Preface -- Preface -- About the Companion Website -- Part I Historical Introduction to the GnRH Neuron -- Chapter 1 The Framework Upon Which Current Research on the GnRH Neuron and its Control is Built -- Abstract -- 1.1 Introduction -- 1.2 Approaches taken to study the GnRH neuron -- 1.3 The future -- References -- Part II GnRH Neuron Development -- Chapter 2 Prenatal Development of GnRH Neurons -- Abstract -- 2.1 Introduction -- 2.2 GnRH -- 2.3 The migratory track -- 2.4 Migration mechanics -- 2.5 Perspectives -- 2.6 Protocols -- Acknowledgments -- Glossary -- References -- Chapter 3 Fetal/perinatal Programming Causing Sexual Dimorphism of the Kisspeptin-GnRH Neuronal Network -- Abstract -- 3.1 Discovery of perinatal programming of the GnRH/gonadotropin‐releasing system by sex steroids in rodents -- 3.2 Critical periods responsible for sexual dimorphism of the GnRH/gonadotropin‐releasing system -- 3.3 Sexual dimorphism of kisspeptin neurons and the GnRH‐releasing system in rodents -- 3.4 Potential mechanisms mediating fetal/perinatal programming of the kisspeptin-GnRH neuronal network in rodents -- 3.5 Species difference in programming of the kisspeptin-GnRH neuronal network -- 3.6 Perspectives -- Acknowledgments -- References -- Chapter 4 Postnatal Development of GnRH Neuronal Function -- Abstract -- 4.1 Introduction -- 4.2 Historical perspectives -- 4.3 Postnatal development of the GnRH system -- 4.4 The mechanism of the pubertal increase in GnRH release -- 4.6 Perspectives -- Acknowledgments -- References -- Part III GnRH Neuron Biology -- Chapter 5 Regulation of GnRH Gene Expression -- Abstract -- 5.1 The Gnrh1 gene and its transcript -- 5.2 Regulation of Gnrh1 transcription -- 5.3 Transcription factors regulating Gnrh1 transcription. 5.4 Gnrh1 chromatin structure is critical for increased transcription of Gnrh1 during GnRH neuron development -- 5.5 Gnrh1 transcription regulation by noncoding RNAs -- 5.6 Perspectives -- Acknowledgments -- Appendices -- References -- Chapter 6 Morphology of the Adult GnRH Neuron -- Abstract -- 6.1 Introduction -- 6.2 Immunolabeling of GnRH peptide -- 6.3 Transgenics pave the way toward the bigger picture -- 6.4 Putting the pieces together: visualizing the whole GnRH neuron -- 6.5 Perspectives -- Acknowledgments -- Glossary -- References -- Chapter 7 The Anatomy of the GnRH Neuron Network in the Human -- Abstract -- 7.1 Ethical considerations -- 7.2 IHC studies of developing human GnRH neurons -- 7.3 Studying GnRH neuron anatomy in adults with ISH -- 7.4 IHC studies of human GnRH neurons in adults -- 7.5 Perspectives -- Acknowledgments -- References -- Chapter 8 Electrophysiology of Rodent GnRH Neurons -- Abstract -- 8.1 Historical perspective -- 8.2 Experimental models and recording configurations used for GnRH neuron electrophysiology -- 8.3 Overview of the intrinsic properties of GnRH neurons -- 8.4 Neurotransmission and neuromodulation -- 8.5 Perspectives -- Acknowledgement -- References -- Chapter 9 Anatomy and Physiology of GnRH Neurons and Their Control of Pituitary Function in Fish -- Abstract -- 9.1 Introduction -- 9.2 Anatomy and ontogeny of GnRH neurons, with special reference to the hypophysiotropic GnRH1 neurons -- 9.3 Electrophysiology of hypophysiotropic GnRH1 neurons in fish -- 9.4 Physiological functions of teleost GnRH1 neurons: implications from gene KO animals -- 9.5 Perspectives -- Acknowledgments -- References -- Part IV Regulation of GnRH Neuron Function -- Chapter 10 Unveiling the Importance of Glia and Vascular Endothelial Cells in the Control of GnRH Neuronal Function -- Abstract. 10.1 Defining the functional microunit in the GnRH neuroendocrine network -- 10.2 Visualizing morphological interactions between GnRH neurons and glial cells -- 10.3 Evidence for gliotransmission in the GnRH neural network -- 10.4 Probing function‐related structural plasticity in the GnRH neural network -- 10.5 Deciphering the cell‐to‐cell communication processes underlying structural plasticity -- 10.6 Perspectives -- Acknowledgments -- Glossary -- References -- Chapter 11 Genetic Strategies Examining Kisspeptin Regulation of GnRH Neurons -- Abstract -- 11.1 Introduction -- 11.2 The ARC kisspeptin neuron population -- 11.3 The AVPV/PeN kisspeptin neurons -- 11.4 Steroidogenic control of GnRH neurons via kisspeptin neurons -- 11.5 Interrogation of kisspeptin neurobiology -- 11.6 How comparable is the rodent to the human? -- 11.7 Perspectives -- Acknowledgments -- Glossary -- References -- Chapter 12 KNDy Hypothesis for Generation of GnRH Pulses: Evidence from Sheep and Goats -- Abstract -- 12.1 Introduction -- 12.2 Anatomical approaches -- 12.3 Functional approaches: local administration of receptor agonists and antagonists and assessment of MUA -- 12.4 Integration: the KNDy hypothesis in ruminants and rodents -- 12.5 Perspectives -- Acknowledgments -- Appendices -- References -- Chapter 13 Generation of the GnRH Surge and LH Surge by the Positive Feedback Effect of Estrogen -- Abstract -- 13.1 Introduction -- 13.2 Historical perspective on the concept of positive feedback and models in rodents -- 13.3 ER‐expressing neurons in the brain and positive feedback -- 13.4 Progesterone and positive feedback -- 13.5 Circadian rhythm and positive feedback -- 13.6 Special aspects of positive feedback in non‐rodent species -- 13.7 Strength and duration of the E2 signal and positive feedback -- 13.8 Multi‐unit recording of neurons and positive feedback. 13.9 Positive feedback at the level of the pituitary gonadotropes -- 13.10 Perspectives -- Acknowledgments -- Glossary -- References -- Chapter 14 Influence of Stress on the GnRH Neuronal Network -- Abstract -- 14.1 Introduction -- 14.2 Neuroendocrine mechanisms underlying the effects of stress on the GnRH system -- 14.3 Effects of stress on reproductive health -- 14.4 Perspectives -- Appendix: a selection of common stress paradigms -- References -- Chapter 15 Metabolic Regulation of GnRH Neurons -- Abstract -- 15.1 Introduction -- 15.2 Hormonal metabolic cues to GnRH neurons -- 15.3 Identifying neuronal targets of metabolic hormones -- 15.4 Functional assessment of putative metabolic pathways to the GnRH neuron -- 15.5 Animal models of infertility due to nutritional excess -- 15.6 Perspectives -- Acknowledgments -- References -- Chapter 16 Seasonal Control of the GnRH Neuronal Network as a Means of Uncovering Novel Central Mechanisms Governing Mammalian Reproduction -- Abstract -- 16.1 Introduction -- 16.2 Photoperiodic changes in melatonin and the seasonal control of reproduction -- 16.3 Methods for the analysis of seasonal changes in the hypothalamus -- 16.4 Pharmacological approaches to the study of the regulation of seasonal reproduction -- 16.5 Perspectives -- References -- Part V GnRH in the Clinic -- Chapter 17 Human Genetics of GnRH Neuron Function -- Abstract -- 17.1 Introduction -- 17.2 Human phenotypes of early and late pubertal development -- 17.3 KNDy neurons as the GnRH pulse generator -- 17.4 Genome‐wide association studies on the age of menarche -- 17.5 Finding new puberty genes -- 17.6 Challenges in finding new puberty genes -- 17.7 Perspectives -- Glossary -- Acknowledgement -- References -- Chapter 18 Modulators of GnRH Secretion and Therapeutic Applications -- Abstract -- 18.1 Introduction -- 18.2 GnRH analogs. 18.3 Kisspeptin analogs -- 18.4 NKB analogs -- 18.5 Perspectives -- Acknowledgments -- Glossary -- References -- Index -- EULA.
9781119233268
Neurons-Physiology.
Electronic books.
QP363 .G574 2018
The GnRH Neuron and Its Control. - 1st ed. - 1 online resource (536 pages) - Wiley-INF Masterclass in Neuroendocrinology Series . - Wiley-INF Masterclass in Neuroendocrinology Series .
Cover -- Title Page -- Copyright -- Contents -- List of Contributors -- Series Preface -- Preface -- About the Companion Website -- Part I Historical Introduction to the GnRH Neuron -- Chapter 1 The Framework Upon Which Current Research on the GnRH Neuron and its Control is Built -- Abstract -- 1.1 Introduction -- 1.2 Approaches taken to study the GnRH neuron -- 1.3 The future -- References -- Part II GnRH Neuron Development -- Chapter 2 Prenatal Development of GnRH Neurons -- Abstract -- 2.1 Introduction -- 2.2 GnRH -- 2.3 The migratory track -- 2.4 Migration mechanics -- 2.5 Perspectives -- 2.6 Protocols -- Acknowledgments -- Glossary -- References -- Chapter 3 Fetal/perinatal Programming Causing Sexual Dimorphism of the Kisspeptin-GnRH Neuronal Network -- Abstract -- 3.1 Discovery of perinatal programming of the GnRH/gonadotropin‐releasing system by sex steroids in rodents -- 3.2 Critical periods responsible for sexual dimorphism of the GnRH/gonadotropin‐releasing system -- 3.3 Sexual dimorphism of kisspeptin neurons and the GnRH‐releasing system in rodents -- 3.4 Potential mechanisms mediating fetal/perinatal programming of the kisspeptin-GnRH neuronal network in rodents -- 3.5 Species difference in programming of the kisspeptin-GnRH neuronal network -- 3.6 Perspectives -- Acknowledgments -- References -- Chapter 4 Postnatal Development of GnRH Neuronal Function -- Abstract -- 4.1 Introduction -- 4.2 Historical perspectives -- 4.3 Postnatal development of the GnRH system -- 4.4 The mechanism of the pubertal increase in GnRH release -- 4.6 Perspectives -- Acknowledgments -- References -- Part III GnRH Neuron Biology -- Chapter 5 Regulation of GnRH Gene Expression -- Abstract -- 5.1 The Gnrh1 gene and its transcript -- 5.2 Regulation of Gnrh1 transcription -- 5.3 Transcription factors regulating Gnrh1 transcription. 5.4 Gnrh1 chromatin structure is critical for increased transcription of Gnrh1 during GnRH neuron development -- 5.5 Gnrh1 transcription regulation by noncoding RNAs -- 5.6 Perspectives -- Acknowledgments -- Appendices -- References -- Chapter 6 Morphology of the Adult GnRH Neuron -- Abstract -- 6.1 Introduction -- 6.2 Immunolabeling of GnRH peptide -- 6.3 Transgenics pave the way toward the bigger picture -- 6.4 Putting the pieces together: visualizing the whole GnRH neuron -- 6.5 Perspectives -- Acknowledgments -- Glossary -- References -- Chapter 7 The Anatomy of the GnRH Neuron Network in the Human -- Abstract -- 7.1 Ethical considerations -- 7.2 IHC studies of developing human GnRH neurons -- 7.3 Studying GnRH neuron anatomy in adults with ISH -- 7.4 IHC studies of human GnRH neurons in adults -- 7.5 Perspectives -- Acknowledgments -- References -- Chapter 8 Electrophysiology of Rodent GnRH Neurons -- Abstract -- 8.1 Historical perspective -- 8.2 Experimental models and recording configurations used for GnRH neuron electrophysiology -- 8.3 Overview of the intrinsic properties of GnRH neurons -- 8.4 Neurotransmission and neuromodulation -- 8.5 Perspectives -- Acknowledgement -- References -- Chapter 9 Anatomy and Physiology of GnRH Neurons and Their Control of Pituitary Function in Fish -- Abstract -- 9.1 Introduction -- 9.2 Anatomy and ontogeny of GnRH neurons, with special reference to the hypophysiotropic GnRH1 neurons -- 9.3 Electrophysiology of hypophysiotropic GnRH1 neurons in fish -- 9.4 Physiological functions of teleost GnRH1 neurons: implications from gene KO animals -- 9.5 Perspectives -- Acknowledgments -- References -- Part IV Regulation of GnRH Neuron Function -- Chapter 10 Unveiling the Importance of Glia and Vascular Endothelial Cells in the Control of GnRH Neuronal Function -- Abstract. 10.1 Defining the functional microunit in the GnRH neuroendocrine network -- 10.2 Visualizing morphological interactions between GnRH neurons and glial cells -- 10.3 Evidence for gliotransmission in the GnRH neural network -- 10.4 Probing function‐related structural plasticity in the GnRH neural network -- 10.5 Deciphering the cell‐to‐cell communication processes underlying structural plasticity -- 10.6 Perspectives -- Acknowledgments -- Glossary -- References -- Chapter 11 Genetic Strategies Examining Kisspeptin Regulation of GnRH Neurons -- Abstract -- 11.1 Introduction -- 11.2 The ARC kisspeptin neuron population -- 11.3 The AVPV/PeN kisspeptin neurons -- 11.4 Steroidogenic control of GnRH neurons via kisspeptin neurons -- 11.5 Interrogation of kisspeptin neurobiology -- 11.6 How comparable is the rodent to the human? -- 11.7 Perspectives -- Acknowledgments -- Glossary -- References -- Chapter 12 KNDy Hypothesis for Generation of GnRH Pulses: Evidence from Sheep and Goats -- Abstract -- 12.1 Introduction -- 12.2 Anatomical approaches -- 12.3 Functional approaches: local administration of receptor agonists and antagonists and assessment of MUA -- 12.4 Integration: the KNDy hypothesis in ruminants and rodents -- 12.5 Perspectives -- Acknowledgments -- Appendices -- References -- Chapter 13 Generation of the GnRH Surge and LH Surge by the Positive Feedback Effect of Estrogen -- Abstract -- 13.1 Introduction -- 13.2 Historical perspective on the concept of positive feedback and models in rodents -- 13.3 ER‐expressing neurons in the brain and positive feedback -- 13.4 Progesterone and positive feedback -- 13.5 Circadian rhythm and positive feedback -- 13.6 Special aspects of positive feedback in non‐rodent species -- 13.7 Strength and duration of the E2 signal and positive feedback -- 13.8 Multi‐unit recording of neurons and positive feedback. 13.9 Positive feedback at the level of the pituitary gonadotropes -- 13.10 Perspectives -- Acknowledgments -- Glossary -- References -- Chapter 14 Influence of Stress on the GnRH Neuronal Network -- Abstract -- 14.1 Introduction -- 14.2 Neuroendocrine mechanisms underlying the effects of stress on the GnRH system -- 14.3 Effects of stress on reproductive health -- 14.4 Perspectives -- Appendix: a selection of common stress paradigms -- References -- Chapter 15 Metabolic Regulation of GnRH Neurons -- Abstract -- 15.1 Introduction -- 15.2 Hormonal metabolic cues to GnRH neurons -- 15.3 Identifying neuronal targets of metabolic hormones -- 15.4 Functional assessment of putative metabolic pathways to the GnRH neuron -- 15.5 Animal models of infertility due to nutritional excess -- 15.6 Perspectives -- Acknowledgments -- References -- Chapter 16 Seasonal Control of the GnRH Neuronal Network as a Means of Uncovering Novel Central Mechanisms Governing Mammalian Reproduction -- Abstract -- 16.1 Introduction -- 16.2 Photoperiodic changes in melatonin and the seasonal control of reproduction -- 16.3 Methods for the analysis of seasonal changes in the hypothalamus -- 16.4 Pharmacological approaches to the study of the regulation of seasonal reproduction -- 16.5 Perspectives -- References -- Part V GnRH in the Clinic -- Chapter 17 Human Genetics of GnRH Neuron Function -- Abstract -- 17.1 Introduction -- 17.2 Human phenotypes of early and late pubertal development -- 17.3 KNDy neurons as the GnRH pulse generator -- 17.4 Genome‐wide association studies on the age of menarche -- 17.5 Finding new puberty genes -- 17.6 Challenges in finding new puberty genes -- 17.7 Perspectives -- Glossary -- Acknowledgement -- References -- Chapter 18 Modulators of GnRH Secretion and Therapeutic Applications -- Abstract -- 18.1 Introduction -- 18.2 GnRH analogs. 18.3 Kisspeptin analogs -- 18.4 NKB analogs -- 18.5 Perspectives -- Acknowledgments -- Glossary -- References -- Index -- EULA.
9781119233268
Neurons-Physiology.
Electronic books.
QP363 .G574 2018