Enteroviruses : Omics, Molecular Biology, and Control.
Jackson, William T.
Enteroviruses : Omics, Molecular Biology, and Control. - 1st ed. - 1 online resource (164 pages)
Intro -- Contents -- Current Books of Interest -- Preface -- 1 Enteroviruses Future -- Introduction -- Curiouser and curiouser -- Viral eradication and control by vaccination -- Antivirals: crucial for post eradication of poliovirus and needed for all Enteroviruses -- Enteroviruses in 10 years -- 2 Enterovirus Receptors and Entry -- Introduction -- The Enterovirus capsid -- Attachment to a cellular receptor -- Use of multiple receptors -- Uncoating: formation of expanded A-particles -- Uncoating: RNA release -- Where does uncoating occur? -- Introduction to endocytosis -- Other forms of endocytosis -- Post-internalization events -- Concluding thoughts -- 3 Hijacking Host Functions for Translation and RNA Replication by Enteroviruses -- Introduction -- Viral proteinase disruption of host machinery -- Use and abuse of host cell functions for viral translation and RNA replication -- Evasion of host antiviral and stress response pathways and mRNA surveillance -- Summary -- 4 The Omics of Rhinoviruses -- The Rhinoviruses -- How RV taxa are defined -- Making an informative alignment -- Prediction of an RV-C capsid -- Statistical prediction of immunogenicity -- Other uses for RV sequences -- 5 Viral Population Dynamics and Sequence Space -- Quasispecies dynamics of Enteroviruses: model RNA viruses -- Mutation rates and RdRp fidelity -- Recombination -- Sequence space and fitness landscapes -- Viral adaptation dynamics: step-wise walks along the landscape -- Intra-population interactions: complementation and interference -- Group contribution of minority variants to phenotype -- The genomics era: challenges and prospects of high-throughput sequencing technologies -- Final conclusions -- 6 Enterovirus Control of Cytoplasmic RNA Granules -- Cytoplasmic RNA granules -- Mechanisms of stress granule assembly. Enterovirus relationships with stress granules: antagonism rules -- How does G3BP cleavage block stress granule assembly? -- Enterovirus relationships with P-bodies: rapid destruction -- Why Enteroviruses must antagonize RNA granules -- Future directions -- 7 The Autophagic Pathway and Enterovirus Infection -- Autophagy was first identified in Enterovirus infections through electron microscopy -- Basics of autophagy -- The relationship between Enteroviruses and autophagy -- Release of Enteroviruses without lysis -- Enterovirus proteins promote autophagic signalling and degradation -- Triggering of autophagy upon virus entry -- Coxsackievirus regulation of the autophagy pathway -- Enterovirus 71 -- Rhinovirus -- The dual nature of autophagy -- The current model -- 8 The Lipid Blueprints of Replicating Viral Genomes -- Introduction -- Membranes facilitate replication -- Convergence on a common lipid blueprint -- Advantages of enriching for PI4P lipids in replication organelles -- Mechanisms and consequences of viral induction of PI4P lipid production -- Phosphatidylethanolamine -- Cholesterol: co-factor to stabilize PI4P and phosphatidylethanolamine domains -- Viral mechanisms of obtaining cholesterol -- Therapeutic potential of targeting lipids and future directions -- Index.
This book represents a comprehensive tour of the current most important enterovirus research. The editors, Dr. Jackson and Dr. Coyne, have assembled a group of enteroviral experts who cover topics including viral entry and the hijacking of host functions; the dynamic analysis of ever-evolving virus genomes; the cellular membrane changes promoting virus assembly and release. This volume is a must-read for anyone with an interest in this family of viruses and an important acquisition for all microbiology libraries.
9781910190746
Enteroviruses.
Electronic books.
QR410.2.E55 .E584 2018
576.6484
Enteroviruses : Omics, Molecular Biology, and Control. - 1st ed. - 1 online resource (164 pages)
Intro -- Contents -- Current Books of Interest -- Preface -- 1 Enteroviruses Future -- Introduction -- Curiouser and curiouser -- Viral eradication and control by vaccination -- Antivirals: crucial for post eradication of poliovirus and needed for all Enteroviruses -- Enteroviruses in 10 years -- 2 Enterovirus Receptors and Entry -- Introduction -- The Enterovirus capsid -- Attachment to a cellular receptor -- Use of multiple receptors -- Uncoating: formation of expanded A-particles -- Uncoating: RNA release -- Where does uncoating occur? -- Introduction to endocytosis -- Other forms of endocytosis -- Post-internalization events -- Concluding thoughts -- 3 Hijacking Host Functions for Translation and RNA Replication by Enteroviruses -- Introduction -- Viral proteinase disruption of host machinery -- Use and abuse of host cell functions for viral translation and RNA replication -- Evasion of host antiviral and stress response pathways and mRNA surveillance -- Summary -- 4 The Omics of Rhinoviruses -- The Rhinoviruses -- How RV taxa are defined -- Making an informative alignment -- Prediction of an RV-C capsid -- Statistical prediction of immunogenicity -- Other uses for RV sequences -- 5 Viral Population Dynamics and Sequence Space -- Quasispecies dynamics of Enteroviruses: model RNA viruses -- Mutation rates and RdRp fidelity -- Recombination -- Sequence space and fitness landscapes -- Viral adaptation dynamics: step-wise walks along the landscape -- Intra-population interactions: complementation and interference -- Group contribution of minority variants to phenotype -- The genomics era: challenges and prospects of high-throughput sequencing technologies -- Final conclusions -- 6 Enterovirus Control of Cytoplasmic RNA Granules -- Cytoplasmic RNA granules -- Mechanisms of stress granule assembly. Enterovirus relationships with stress granules: antagonism rules -- How does G3BP cleavage block stress granule assembly? -- Enterovirus relationships with P-bodies: rapid destruction -- Why Enteroviruses must antagonize RNA granules -- Future directions -- 7 The Autophagic Pathway and Enterovirus Infection -- Autophagy was first identified in Enterovirus infections through electron microscopy -- Basics of autophagy -- The relationship between Enteroviruses and autophagy -- Release of Enteroviruses without lysis -- Enterovirus proteins promote autophagic signalling and degradation -- Triggering of autophagy upon virus entry -- Coxsackievirus regulation of the autophagy pathway -- Enterovirus 71 -- Rhinovirus -- The dual nature of autophagy -- The current model -- 8 The Lipid Blueprints of Replicating Viral Genomes -- Introduction -- Membranes facilitate replication -- Convergence on a common lipid blueprint -- Advantages of enriching for PI4P lipids in replication organelles -- Mechanisms and consequences of viral induction of PI4P lipid production -- Phosphatidylethanolamine -- Cholesterol: co-factor to stabilize PI4P and phosphatidylethanolamine domains -- Viral mechanisms of obtaining cholesterol -- Therapeutic potential of targeting lipids and future directions -- Index.
This book represents a comprehensive tour of the current most important enterovirus research. The editors, Dr. Jackson and Dr. Coyne, have assembled a group of enteroviral experts who cover topics including viral entry and the hijacking of host functions; the dynamic analysis of ever-evolving virus genomes; the cellular membrane changes promoting virus assembly and release. This volume is a must-read for anyone with an interest in this family of viruses and an important acquisition for all microbiology libraries.
9781910190746
Enteroviruses.
Electronic books.
QR410.2.E55 .E584 2018
576.6484