Horizons in World Cardiovascular Research.

Intro -- HORIZONS IN WORLD CARDIOVASCULAR RESEARCH -- HORIZONS IN WORLD CARDIOVASCULAR RESEARCH -- CONTENTS -- PREFACE -- ELECTRICAL RESTITUTION AND VENTRICULAR TACHYARRHYTHMIA: PATHOPHYSIOLOGICAL AND CLINICAL IMPLICATIONS -- Abstract -- Introduction -- Original Studies -- Follow-Ups -- Restitution Hypothesis: Formulation and the First Evidence to Support -- APD Alternans -- Methodological Issues -- APD Restitution Curve: Reconstruction and Analysis -- Which Stimulation Protocol Is Better? -- Pacing Cycle Length -- APD during Steady-State Pacing -- Location of Pacing Site -- Temperature-Dependent changes -- Effects of Multiple Premature Extrastimuli -- Cellular Mechanisms of Electrical Restitution -- Incomplete Recovery of Ionic Currents -- Inward Currents (INa and ICa) -- The Delayed Rectifier (IK) -- The Transient Outward K+ Current (Ito) -- The Inward Na+-Ca2+ Exchange Current (INa-Ca) -- Which Ionic Current Is the Most Important for APD Restitution? -- Changes in Intracellular and Extracellular Ion Concentrations -- Spatial Heterogeneities in Electrical Restitution -- Tissue-Specific Heterogeneities of APD Restitution: Ventricular Muscle vs. Purkinje Fibers -- Electrical Restitution Properties In Cardiac Disease -- Electrical Restitution Properties: the Impact of Various Pathophysiological Factors -- Sympathetic stimulation -- Parasympathetic stimulation -- Myocardial ischemia -- Myocardial stretch -- Changes in extracellular ions concentration -- Extracellular K+ -- Extracellular Ca2+ -- Pharmacological Modulation of Electrical Restitution: Computational and Experimental Studies -- Ca2+ Channel Antagonists -- Na+ Channel Antagonists -- Class III Antiarrhythmic Agents (IK Blockers) -- Antiarrhythmic Drugs with Complex Mechanism of Action -- K+ Channel Openers -- Excitation-Contraction Uncoupling Agents.

Sarcoplasmic Reticulum Ca2+ Store-Depleting Agents -- Nitric Oxide (NO) Donors -- The Restitution Hypothesis: Shortcomings and Criticism -- Conduction Velocity Restitution -- Cardiac Memory -- Electrotonic Effects -- Cardiac Anatomy -- Spatial Repolarization Gradients -- The Size of the Central Core around which the Spiral Wave is Rotated -- Spiral Wave Collisions -- Abnormal Ca2+ Cycling -- Electrical Restitution and Vulnerability to Reentry -- Slope Values: Are They Always Measured Correctly? -- Conclusion -- References -- SURGICAL MANAGEMENT OF CHRONIC ISCHEMIC MITRAL REGURGITATION -- Abstract -- Introduction -- Consequences of Ischemic Mitral Regurgitation -- Evidence for More Aggressive Management of Ischemic Mitral Regurgitation -- Mechanisms of Ischemic MR -- Outcomes of Repair in Ischemic Mitral Regurgitation -- Types of Repair for Ischemic Mitral Regurgitation -- Conclusions -- References -- PLATELET BIOLOGY IN PATHOPHYSIOLOGY OF CARDIOVASCULAR DISEASES: CLINICAL RISK CONSIDERATIONS -- Abstract -- Background -- Platelets in Pathogenesis of Atherosclerosis -- Platelets and Inflammation -- Platelets and Dyslipidemia -- Platelets and Diabetes -- Platelets and Smoking -- Platelets and Hypertension -- Platelets and OSA -- Platelets and Coronary Artery Disease -- Platelets and Ischemic Cerebrovascular Disease -- Platelets and PAD -- Conclusion -- References -- HOME HOSPITAL CARE FOR CONGESTIVE HEART FAILURE: PORTLAND VA MEDICAL CENTER PROGRAM @ HOME -- Abstract -- Introduction -- Development of Program at Home and Process of Care for Patients with CHF -- Results -- Discussion -- Recommendations -- Acknowledgment -- References -- A REVIEW OF INTRAOPERATIVE TRANSESOPHAGEAL ECHOCARDIOGRAPHY FOR NONCARDIAC SURGERY -- Abstract -- Introduction -- Indications -- Comparison of Pulmonary Artery Catheter and TEE -- Complications -- Training and Proficiency.

The Role of Transthoracic Echocardiography -- Conclusion -- References -- THE INCIDENCE OF SECONDARY HEART TUMOURS IN DOGS AND CATS -- Abstract -- Introduction -- Material and Methods -- Cases -- Post-mortem Examination and Specimens -- Histopathology and Immunohistochemistry (IHC) -- Results -- Cardiac Neoplasms in Dogs -- Clinical Findings -- Pathological Findings -- Cardiac Neoplasms in Cats -- Clinical Findings -- Pathological Findings -- Discussion -- References -- THE ROLE OF HMGB1 IN CARDIAC DYSFUNCTION DURING SEPTIC SHOCK -- Abstract -- Introduction -- Mechanism of Sepsis-Related Cardiac Dysfunction -- The Role of HMGB1 in Sepsis and as a Potential Therapeutic Target -- Conclusion -- References -- IMAGE-DRIVEN COMPUTATIONAL MODELS OF THE HEART FOR TETRALOGY OF FALLOT -- Abstract -- 1.Introduction -- 2.QuantifyingCardiacDeformationfromImages -- 2.1.Background -- 2.2.Physiologically-ConstrainedImageRegistrationMethod -- 2.2.1.EfficientDiffeomorphicImageRegistrationwithLog-DomainDemons -- 2.2.2.IntegrationofCardiacElasticityConstraint -- 2.2.3.IntegrationofCardiacNear-IncompressibilityConstraint -- 2.2.4.EstimationofMyocardiumStrain -- 2.3.ResultonaPatientwithRepairedTetralogyofFallot -- 2.4.Discussion -- 3.StatisticalModelofRightVentricleGrowthandRemodelling -- 3.1.EstimationofaRepresentativeTemplateoftheRightVentricle -- 3.1.1.ClinicalDataoftheStudy -- 3.1.2.UnbiasedTemplateoftheRightVentricle -- 3.2.AGenerativeModelofRightVentricleGrowthandRemodelling -- 3.2.1.ModelDimensionReduction -- 3.2.2.CorrelationAnalysis -- 3.3.GeneralisationoftheRightVentricleGrowthModel -- 3.4.Discussion -- 4.PersonalisedSimulationofPulmonaryValveReplacement -- 4.1.PersonalisedModelofCardiacElectromechanicsinrToF -- 4.1.1.CardiacAnatomyModel -- 4.1.2.CardiacElectrophysiologyModel -- 4.1.3.CardiacBiomechanicsModel.

4.1.4.CardiacHemodynamicsModelandBoundaryConditions -- 4.2.Real-TimeSimulationofPulmonaryValveReplacement -- 4.3.ExperimentandResults -- 4.3.1.ElectromechanicalModelPersonalisation -- 4.3.2.PreoperativeSimulation -- 4.3.3.SimulationofPVRwithRVVolumeReduction -- 4.4.Discussion -- 5.Conclusion -- Acknowledgement -- References -- DIETARY INTERVENTION FOR ACUTE CORONARY SYNDROME -- 1. Synopsis -- 2. Introduction -- 2.1. Prevalence of Risk Factors for ACS -- Inflammation And ACS -- 2.2. ACS and Autoimmunity -- 3. Macronutrients -- 3.1. Energy -- 3.2. Dietary Fats -- Total Fat -- Poly-Unsatrurated Fats -- Trans Fatty Acids -- Saturated Fat -- Cholesterol -- Alpha-Lipoic Acid -- 3.3. Proteins -- 3.4. Carbohydrates -- Dietary Fiber -- Fruit and Vegetables -- The Mediterranean Diet -- 4. Micronutrients -- 4.1. Antioxidants -- 4.2. Antioxidant Vitamins -- 4.3. Lycopene -- 4.4. Carnitine -- 4.5. Coenzyme Q10 -- 4.6. Trace Elements -- 5. Phytochemicals -- Resveratrol -- 6. Dairy Foods and Calcium -- 7. Red Palm Oil -- 8. Curcumin -- Conclusion -- References -- INDEX.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.