Developmental Gene Expression Regulation.

Intro -- DEVELOPMENTAL GENE EXPRESSION REGULATION -- DEVELOPMENTAL GENE EXPRESSION REGULATION -- Contents -- Preface -- Chapter I Gene Regulation and Early Developmental Gene Expression in Vertebrate -- Abstract -- Introduction -- Gene Regulation in Germ Cell Specification -- VASA: A Germplasmic Determinant for Germ Cell Formation and Migration -- Stem Cells and ES Cells -- Cytokine LIF In ES Cell Culture -- Factors Maintain Self-Renewal and Pluripotency of Mouse ES Cells -- Transcription Factors Specify Human ES Cells -- Gene Regulation of Sex Determination in Vertebrate -- Dynamic Expression of Factors Involved In Sexual Development -- Gene Regulation in Sexual Development -- Alternative Splicing to Regulate the Gonadal Fates -- Signaling Networks and Crosstalk in Gene Regulation -- Conclusion -- References -- Chapter II Regulation of Gene Expression during Aging -- Abstract -- Introduction -- Aging and Genetic Regulation of Aging: The Debate -- Evolutionary Senescence Theory of Aging -- Nutrition in Development and Aging -- Insulin /IGF -Insulin like Growth Factor- Signaling (IIS) -- Biological Functions of IIS -- IIS and Longevity -- Forkhead Transcription Factors -- FoxOs -- Biological Functions of FoxOs -- Foxos and Longevity -- Post-Translational Modifications of Foxo Proteins -- FoxAs -- Biological Functions of FoxAs -- FoxAs and Longevity -- TOR: Nutrition Sensing Pathway -- Biological Functions of TOR -- TOR Pathway and Longevity -- Stress-Responsive Jun-N-Terminal Kinase (JNK) Pathway -- Biological Functions of JNK -- JNK Pathway and Longevity -- Conclusion -- References -- Chapter III Developmental Regulation of Sensory Receptor Gene Expression -- Abstract -- Introduction -- 1. Regulation of Sensory Receptor Genes in the Olfactory System -- 1.1. Mouse Olfactory System.

1.1.1. Maintained Neurogenesis in the Olfactory System -- 1.1.2. The Mouse OR Genes -- 1.1.3. Evidence for Mutually Exclusive Monoallelic Expression of OR Genes -- 1.1.4. ORs and Axonal Targeting -- 1.1.5. Gene Choice and Regulation of OR Gene Expression -- 1.2. Fly Olfactory Systems -- 1.2.1. Co-Expression of Or83b with other OR Genes -- 1.2.2. Choice of OR Gene Expression -- 2. Regulation of Sensory Receptor Genes in the Visual System -- 2.1 The Mouse Retina -- 2.2. Human Visual System -- 2.3. Fly Visual System -- 2.3.1 Anatomy of the Fly Eye -- 2.3.2 Characteristics of Rhodopsin Regulatory Regions -- 2.3.3. Different Ommatidia Subtypes -- 2.3.4. Specification Inner PRs -- 2.3.5. Specification Inner PRs Subtypes -- 2.3.6. Alternative Mechanisms of Specifying the Same Set of Rhodopsin Fates -- 2.3.7. A Genetic Program Altering Sensory Specificity by Switching Rhodopsin Expression -- 2.3.8. Genetic Regulation of Sensory Receptor Gene Co-Expression in the Fly Eye -- 3. Conclusion -- Acknowledgments -- References -- Chapter IV Normal and Injury-Induced Gene Expression in the Developing Postnatal Rat Inner Ear -- Abstract -- Introduction -- Material and Methods -- Explant Cultures -- RNA Isolation and Quantification -- Cdna Microarray Analysis -- Statistical Analysis of Microarray Data -- Results -- Cellular Injury Characterization -- Genes Involved in Damaging Mechanisms -- Genes Involved in Cell Death Processes -- Genes Involved in Cell Protective Processes -- Discussion -- Damaging Processes Associated With the Preparation Of Organotypic Cultures -- Endogenous Mechanisms to Maintain Cell Survival In Culture -- Consequences of the Changed Gene Expression -- Conclusion -- References -- Chapter V The TGF-Β Superfamily: A Multitask Signalling Pathway for the Animal Kingdom -- Abstract -- 1. Introduction -- 2. TGF-β Pathway.

3. TGF-β and Regeneration -- 3.1. Overview -- 3.2. TGF-Β Homologs in Regenerating Invertebrates -- 4. Myostatin (GDF8) and Muscle Development -- 4.1. Overview -- 4.2. Myostatin and Fish Development -- 4.3. Myostatin and Bird Development -- 4.4. Myostatin and Mammalian Development -- 4.5. Myostatin Expression in Co-Culture, Exercise Training and NMES Experiments -- 5. Conclusive Remarks -- Acknowledgments -- References -- Chapter VI Alpha-Foetoprotein: It's all About Timing -- Abstract -- AFP: A Brief Introduction -- AFP Gene Regulation -- The AFP Knock-Out Mouse -- Link between AFP and Fertility: Estrogens -- References -- Chapter VII Molecular Mechanisms of Cell-Specific Expression of Neuropeptide Hormone Genes, DH-PBAN and PTTH in the Silkworm, Bombyx Mori -- Abstract -- 1. Neuropeptide Hormones and Neurosecretory Cells Involved in Diapause and Metamorphosis of the Silkworm, Bombyx Mori -- 2. Acnpv-Mediated Gene Transfer System in the Central Nervous System of the Silkworm, Bombyx Mori -- 3. EGFP Expression in a Specific Set of Neuropeptide Hormone-Producing Neurosecretory Cells of the CNS -- 4. Cis-Regulatory Elements Participating with DH-PBAN Expression -- 5. Function of the Pitx Homeobox Gene in the Central Nervous System of Bombyx -- 6. Regulatory Mechanisms of PTTH Expression -- 6. Conclusion -- 7. References -- Chapter VIII Gene Expression Analysis during Development by High-Throughput Methods -- Abstract -- Introduction -- Gene Expression Profiling with Microarrays -- Application of Microarrays to Embryogenomics -- Gene Expression Profiling in Mouse Embryos -- Bioinformatics and Computational Biology -- In Silico Analysis of Genes Promoters -- Conclusions -- Acknowledgements -- References -- Chapter IX Gene Expression Regulation in the Developing Brain -- Abstract -- Introduction -- Sexual Dimorphism of the Brain.

Brain-Sex Differentiation in the Development of Brain Neurotransmitter Systems -- Brain-Sex-Biased Gene Expression in the Sex-Differentiating Brain -- The Development of Brain Neural Circuitry -- Conclusion -- References -- Chapter X Expression and Action of SRY during Gonadal Sex Differentiation in the Mouse -- Abstract -- Introduction -- B6.YTIR (B6.YDOM) Sex Reversal -- Development of Ovotestes and Ovaries in the B6.YTIR Gonad -- The Molecular Mechanism of Sex Reversal in the B6.YTIR Mouse Gonad (Hypothesis) -- Mechanism of Sex Reversal (Hypothesis) -- Sry Transcript Levels during Gonadal Sex Differentiation -- Effects of Genetic Backgrounds on Sry Transcript Levels -- Expression of the SRY Protein during Gonadal Sex Differentiation -- Efficiency of SRY Proteins in Transactivation -- Considerations on the Mechanism of Testicular Differentiation -- Considerations on the Mechanism of Ovarian Differentiation -- References -- Chapter XI The Fibroblast Growth Factor (FGF) Gene Families of Japanese Medaka (Oryzias latipes) -- Abstract -- Introduction -- Methods -- Results -- 3.1. Phylogenetic Analysis of the Medaka fgf Genes -- 3.2. Conserved Synteny Analysis -- 3.2.1. Chromosomal Loci of fgf Genes in Medaka -- 3.2.1. 2. Conserved Gene Order Analysis -- Subfamily fgf1 -- Subfamily fgf4 -- Subfamily fgf7 -- Subfamily fgf8 -- Subfamily fgf9 -- Subfamily fgf11 -- Subfamily fgf19 -- Discussion -- 5. Acknowledgements -- References -- Chapter XII The Role of Internal Fluid Invironment for Regulation of Germ Genes Expression in Early Development of Some Cyprinid Fishes and their Intergeneric F1 Hybrids -- Abstract -- Introduction -- Materials and Methods -- Results and Discussion -- Lipovitellin Identification -- Lipovitellin as Regulator of Early Development -- Conclusion -- References.

Short Communication Cloning and Expression Analysis of the Homeobox Gene Abdominal-A in the Isopod Asellus Aquaticus -- Abstract -- Introduction -- Results and Discussion -- Cloning and Sequence Analysis of the Homeobox Gene Abd-A from Asellus Aquaticus -- Embryonic Development and Gene Expression Pattern of Abd-A in Asellus Aquaticus -- Conclusions -- Material and Methods -- Animals and Embryos -- Whole-Mount in Situ Hybridization and Histological Analysis -- Accession Number -- References -- Index.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.