Safe Nanotechnology in the Workplace.

Intro -- SAFE NANOTECHNOLOGY IN THE WORKPLACE -- SAFE NANOTECHNOLOGY IN THE WORKPLACE -- CONTENTS -- PREFACE -- FOREWORD -- EXECUTIVE SUMMARY -- NANOTECHNOLOGY RESEARCH CENTER -- 1. DETERMINE WHETHER NANOPARTICLES AND NANOMATERIALS POSE RISKS OF INJURIES AND ILLNESSES FOR WORKERS -- 2. CONDUCT RESEARCH ON APPLYING NANOTECHNOLOGY TO THE PREVENTION OF WORK-RELATED INJURIES AND ILLNESSES -- PROMOTE HEALTHY WORKPLACES THROUGH INTERVENTIONS, RECOMMENDATIONS, AND CAPACITY BUILDING -- 4. ENHANCE GLOBAL WORKPLACE SAFETY AND HEALTH THROUGH NATIONAL AND INTERNATIONAL COLLABORATIONS ON NANOTECHNOLOGY RESEARCH AND GUIDANCE -- STEPS TO ADDRESSING OCCUPATIONAL SAFETY AND HEALTH IMPLICATIONS -- NIOSH RESOURCE LIMITATIONS -- ABBREVIATIONS -- ACKNOWLEDGMENTS -- INTRODUCTION -- BACKGROUND -- THE NIOSH ROLE IN OCCUPATIONAL SAFETY AND HEALTH OF NANOTECHNOLOGY WORKERS -- CRITICAL TOPIC AREAS -- 1. Toxicity And Internal Dose -- 2. Risk Assessment -- 3. Epidemiology and Surveillance -- 4. Engineering Controls and PPE -- 5. Measurement Methods -- 6. Exposure Assessment -- 7. Fire and Explosion Safety -- 8. Recommendations and Guidance -- 9. Communication and Education -- 10. Applications -- TOXICITY AND INTERNAL DOSE -- BACKGROUND -- NTRC TOXICOLOGY AND INTERNAL DOSE PROJECTS -- COLLABORATIONS AND PARTNERSHIPS -- ACCOMPLISHMENTS -- ADDITIONAL RESEARCH NEEDS AND FUTURE DIRECTION -- RISK ASSESSMENT -- BACKGROUND -- NTRC RISK ASSESSMENT PROJECTS -- COLLABORATIONS AND PARTNERSHIPS -- ACCOMPLISHMENTS -- ADDITIONAL RESEARCH NEEDS AND FUTURE DIRECTION -- EPIDEMIOLOGY AND SURVEILLANCE -- BACKGROUND -- NTRC EPIDEMIOLOGY AND SURVEILLANCE PROJECTS -- COLLABORATIONS AND PARTNERSHIPS -- ACCOMPLISHMENTS -- ADDITIONAL RESEARCH NEEDS AND FUTURE DIRECTION -- ENGINEERING CONTROLS AND PERSONAL PROTECTIVE EQUIPMENT -- BACKGROUND -- NTRC ENGINEERING CONTROLS AND PPE PROJECTS.

Engineering Controls -- Respirators and other PPE -- COLLABORATIONS AND PARTNERSHIPS -- Engineering Controls -- RESPIRATORS AND OTHER PPE -- ACCOMPLISHMENTS -- Engineering Controls -- Respirators and other PPE -- ADDITIONAL RESEARCH NEEDS AND FUTURE DIRECTION -- MEASUREMENT METHODS -- BACKGROUND -- NTRC MEASUREMENT METHODS PROJECTS -- COLLABORATIONS AND PARTNERSHIPS -- ACCOMPLISHMENTS -- ADDITIONAL RESEARCH NEEDS AND FUTURE DIRECTION -- EXPOSURE ASSESSMENT -- BACKGROUND -- NTRC EXPOSURE ASSESSMENT PROJECTS -- COLLABORATIONS AND PARTNERSHIPS -- ACCOMPLISHMENTS -- ADDITIONAL RESEARCH NEEDS AND FUTURE DIRECTION -- FIRE AND EXPLOSION SAFETY -- BACKGROUND -- FIRE AND EXPLOSION -- NTRC SAFETY PROJECTS -- COLLABORATIONS AND PARTNERSHIPS -- ACCOMPLISHMENTS -- ADDITIONAL RESEARCH NEEDS AND FUTURE DIRECTION -- RECOMMENDATIONS AND GUIDANCE -- BACKGROUND -- NTRC RECOMMENDATIONS AND GUIDANCE PROJECTS -- COLLABORATIONS AND PARTNERSHIPS -- ACCOMPLISHMENTS -- ADDITIONAL RESEARCH NEEDS AND FUTURE DIRECTION -- COMMUNICATION AND EDUCATION -- BACKGROUND -- NTRC COMMUNICATION AND EDUCATION PROJECTS -- COLLABORATIONS AND PARTNERSHIPS -- ACCOMPLISHMENTS -- ADDITIONAL RESEARCH NEEDS AND FUTURE DIRECTION -- APPLICATIONS -- BACKGROUND -- NTRC APPLICATION PROJECTS -- COLLABORATIONS AND PARTNERSHIPS -- ACCOMPLISHMENTS -- ADDITIONAL RESEARCH NEEDS AND FUTURE DIRECTION -- APPENDIX A PROJECT-SPECIFIC PROGRESS REPORTS -- RESEARCH PROGRAM (PROJECTS 1-10): NANOTECHNOLOGY SAFETY AND HEALTH RESEARCH PROGRAM -- PROJECT 1. GENERATION AND CHARACTERIZATION OF OCCUPATIONALLY RELEVANT AIRBORNE NANOPARTICLES -- Accomplishments -- Publications and Abstracts -- Invited Presentations -- PROJECT 2. PULMONARY TOXICITY OF CARBON NANOTUBE PARTICLES -- Accomplishments -- Publications and Abstracts -- Invited Presentations.

PROJECT 3. ROLE OF CARBON NANOTUBES IN CARDIOPULMONARY INFLAMMATION AND COPD-RELATED DISEASES -- Accomplishments -- Publications and Abstracts -- Invited Presentations -- PROJECT 4. PARTICLE SURFACE AREA AS A DOSE METRIC -- Accomplishments -- Publications and Abstracts -- Invited Presentations -- PROJECT 5. ULTRAFINE AEROSOLS FROM DIESEL-POWERED EQUIPMENT -- Accomplishments -- Publications and Abstracts -- PROJECT 6. NANOTECHNOLOGY SAFETY AND HEALTH RESEARCH COORDINATION -- Accomplishments -- PROJECT 7. SYSTEMIC MICROVASCULAR DYSFUNCTION-EFFECT OF ULTRAFINE VERSUS FINE PARTICLES -- Accomplishments -- Publications and Abstracts -- Invited Presentations -- PROJECT 8. PULMONARY DEPOSITION AND TRANSLOCATION OF NANOMATERIALS -- Accomplishments -- Publications and Abstracts -- Invited Presentations -- PROJECT 9. DERMAL EFFECTS OF NANOPARTICLES -- Accomplishments -- Publications and Abstracts -- PROJECT 10. NEUROTOXICITY AFTER PULMONARY EXPOSURE TO WELDING FUMES CONTAINING MANGANESE -- Accomplishments -- Publications and Abstracts -- Invited Presentations -- NANOTECHNOLOGY SAFETY AND HEALTH RESEARCH PROGRAM (PROJECTS 1-10) -- National and International Activities and Conferences -- Dissemination (Interviews and Articles in Lay Press) -- Partnerships and Collaborations -- NTRC Critical Research Topic Areas Addressed -- RESEARCH PROJECT 11. NANOPARTICLES IN THE WORKPLACE PRINCIPAL INVESTIGATOR: MARK HOOVER, PH.D., DRDS/NIOSH/ CDC, PROJECT DURATION: FY 2004-FY 2009 -- Background -- Accomplishments -- Invited Presentations -- Future Presentations -- National and International Activities -- Dissemination (Interviews And Articles in Lay Press) -- Partnerships and Collaborations -- NTRC Critical Research Topic Areas Addressed.

RESEARCH PROJECT 12. NANOPARTICLES-DOSIMETRY AND RISK ASSESSMENT PRINCIPAL INVESTIGATOR: EILEEN D. KUEMPEL, PH.D., EID/ NIOSH/CDC PROJECT DURATION: FY 2004-FY 2009 -- Background -- Accomplishments -- Publications and Abstracts -- Invited Presentations -- National and International Activities and Conferences -- Dissemination (Interviews and Articles in the Lay Press) -- Partnerships and Collaborations -- NTRC Critical Research Topic Areas Addressed -- RESEARCH PROJECT 13. THE MEASUREMENT AND CONTROL OF WORKPLACE NANOMATERIALS PRINCIPAL INVESTIGATORS: DOUG EVANS PH.D., AND KEVIN DUNN M.S., CIH, DART/NIOSH/CDC CO-INVESTIGATORS: EILEEN BIRCH, KEITH CROUCH, BON-KI KU, AND PAUL BARON PROJECT DURATION: FY 2006-FY 2009 -- Background -- Accomplishments (FY 2006) -- Publications and Abstracts -- Invited Presentations -- National And International Activities and Conferences -- Dissemination (Interviews and Articles in the Lay Press) -- Partnerships and Collaborations -- NTRC Critical Research Topic Areas Addressed -- RESEARCH PROJECT 14. TIO2 EXPOSURE ASSESSMENT STUDY PRINCIPLE INVESTIGATOR: BRIAN CURWIN, DSHEFS/NIOSH/CDC PROJECT DURATION: FY 2006-FY 2009 -- Background -- Accomplishments -- Publications and Abstracts -- Invited Presentations -- National or International Activities and Conferences -- Dissemination (Interviews and Articles in the Lay Press) -- Partnerships and Collaborations -- NTRC Critical Research Topic Areas Addressed -- RESEARCH PROJECT 15. EVALUATION OF NANOPARTICLE PENETRATION THROUGH RESPIRATOR FILTER MEDIA PRINCIPLE INVESTIGATOR: SAMY RENGASAMY, PH.D., NPPTL/ NIOSH/CDC PROJECT DURATION: FY 2005-FY 2008 -- Background -- Accomplishments -- Publications and Abstracts -- National and International Activities and Conferences -- Dissemination (Interviews and Articles in The Lay Press) -- Partnerships and Collaborations.

NTRC Critical Research Topic Areas Addressed -- RESEARCH PROJECT 16. DEVELOPMENT OF BENCH AND MIST PROTOCOLS FOR PARTICULATE PENETRATION MEA- SUREMENTS OF PROTECTIVE CLOTHING AND ENSEMBLES PRINCIPLE INVESTIGATOR: PENGFEI GAO, PH.D., C.I.H., NPPTL/ NIOSH/CDC PROJECT DURATION: FY 2006-FY 2009 -- Background -- Accomplishments -- Publications and Abstracts -- Invited Presentations -- Partnerships and Collaborations -- NTRC Critical Research Topic Areas Addressed -- RESEARCH PROJECT 17: WEB-BASED NANOPARTICLE INFORMATION LIBRARY IMPLEMENTATION PRINCIPAL INVESTIGATOR: ARTHUR MILLER, PH.D., SRL/NIOSH/ CDC PROJECT DURATION: FY 2004-FY 2008 -- Background -- Accomplishments -- Publications and Abstracts -- Papers Submitted for Publication -- Posters -- Invited Presentations -- National and International Activities and Conferences -- Dissemination (Interviews and Articles in the Lay Press) -- Partnerships and Collaborations -- NTRC Critical Research Topic Areas Addressed -- APPENDIX B FIELD RESEARCH TEAM PROGRESS REPORT -- Evaluation of Carbon Nanofiber Composite Material at a Polymer Research Facility -- Preliminary Screening Survey Using Handheld Direct Reading Instrumentation and Air Filter/Wipe Samples at A Quantum Dot Research and Development Laboratory -- Evaluation of Nanoscale Metal Oxide Release at a Commercial Technology Development and Powder Production Facility -- Evaluation of Nanoscale Nylon 6 Fiber Deposition and Potential Release During Engine Filter Media Manufacturing -- Preliminary Evaluation of Nanomaterial Handling Practices at a Research Facility Engaged In State-of-the-Art Materials Characterization -- Assessment of Work Practices in a Facility Developing Specially Formulated Fullerenes for Biomedical Applications -- Assessment of Work Practices at Universities Engaged in Research on Nanomaterials.

Evaluation of the Performance of the State-of-the-Art Nanoparticle Sampling Equipment in a Nanoparticle Aerosol Generation Laboratory.

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