Clinical Trials in Psychiatry.

Intro -- Clinical Trials in Psychiatry -- Contents -- Preface to the first edition -- Preface to the second edition -- 1 Treatments, good, bad or worthless - and how do we tell? -- 1.1 Treatments worthless - and worse -- 1.2 A brief history of treating the mentally ill -- 1.3 Summary -- 2 The randomized clinical trial -- 2.1 Introduction -- 2.2 The clinical trial -- 2.3 Ethical issues in clinical trials -- 2.4 Informed consent -- 2.5 Compliance -- 2.6 Summary -- 3 Design issues in clinical trials -- 3.1 Introduction -- 3.2 Clinical trial designs -- 3.3 Methods of randomization -- 3.4 Methods of masking treatments -- 3.5 The size of a clinical trial -- 3.6 Interim analysis -- 3.7 Summary -- 4 Special problems of trials in psychiatry -- 4.1 Introduction -- 4.2 Explanatory versus pragmatic trials -- 4.3 Complex interventions -- 4.4 Outcome measures in psychiatry -- 4.5 Summary -- 5 Some statistical issues in the analysis of psychiatric trials -- 5.1 Introduction -- 5.2 P-values and confidence intervals -- 5.3 Using baseline data -- 5.4 Longitudinal data -- 5.5 Missing values and dropouts in longitudinal data -- 5.6 Multiple outcome measures -- 5.7 Intention-to-treat -- 5.8 Economic evaluation of trials -- 5.9 Number needed to treat -- 5.10 Summary -- 6 Analysing data from a psychiatric trial: an example -- 6.1 Introduction -- 6.2 Beating the Blues -- 6.3 Analysis of the post-treatment BDI scores -- 6.4 Graphical displays and summary measure analysis of longitudinal data -- 6.5 Random effects models for the BtB data -- 6.6 The dropout problem in the BtB data -- 6.7 Summary -- 7 Systematic reviews and meta-analysis -- 7.1 Introduction -- 7.2 Study selection -- 7.3 Publication bias -- 7.4 The statistics of meta-analysis -- 7.5 Some examples of meta-analysis of psychiatric trials -- 7.6 Summary -- 8 RCTs in psychiatry: threats, challenges and the future.

8.1 Introduction -- 8.2 Can randomized clinical trials in psychiatry be justified? -- 8.3 Are randomized clinical trials really necessary? -- 8.4 Conflicts of interest -- 8.5 Scandals, trials and tribulations -- 8.6 The future of psychiatric trials -- 8.7 Defending the clinical trial -- 8.8 Summary -- Appendix A Issues in the management of clinical trials - 'howto do it' -- A.1 Introduction -- A.2 Clinical trial protocols -- A.3 Getting the costs right -- A.4 Collecting and managing the data -- A.5 Writing the patient information sheet -- A.6 Getting informed consent -- A.7 Maintaining recruitment -- A.8 Doing the follow-up -- A.9 Useful web sites -- Appendix B Writing a trial report -- B.1 Introduction -- Appendix C Useful software for clinical trials -- C.1 Introduction -- C.2 Data management -- C.3 Design -- C.4 Analysis -- Bibliography -- Index.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.