Anti-Obesity Drug Discovery and Development Volume 3.

Intro -- CONTENTS -- PREFACE -- List of Contributors -- Current Status of Medical Therapy and New Targets for Anti-Obesity Drug Development -- Chihiro Okuma, Yukihito Ishii and Takeshi Ohta* -- INTRODUCTION -- Approved Drugs -- Phentermine -- Mazindol -- Fenfluramine/Dexfenfluramine -- Orlistat -- Shibutramine -- Rimonabant -- Qsymia -- BELVIQ (Lorcaserin) -- Contrave -- New Drug Targets (Table 3) -- Late Phase Clinical Development -- Early Phase Clinical Stage Development or Pre-Clinical Development Stage Late Phase Clinical Development -- Future Prospects -- Obesity Animal Models -- ob/ob Mouse -- db/db Mouse -- KK-Ay Mouse -- TSOD Mouse -- SDT fatty Rat -- ZF Rat -- ZDF Rat -- cp/cp Rat -- WBN/Kob fatty Rat -- DIO Models -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Unravelling Potential Anorexigen Effects of Nesfatin-1: How Homeostatic Mechanisms Help Balance Excess Calories -- Carmine Finelli* -- INTRODUCTION -- Nesfatin-1/NUCB-2 and Anorexigenic Effect -- The Oxytocin Pathway in Nesfatin-1's Inhibitory Effect on Food Intake -- Nesfatin-1 and CRF -- Nesfatin-1 and Anti-Obesity Treatment -- Nesfatin-1 and Food Behaviour Control -- Nesfatin-1 and Signaling Pathway -- Nesfatin-1 and Eating Disorders -- CONCLUSIVE REMARKS -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- ABBREVIATIONS -- REFERENCES -- Proteomics in the Characterization of New Target Therapies in Pediatric Obesity Treatment -- Gillian E. Walker1,*, Marilisa De Feudis1, Marta Roccio1, Gianni Bona2 and Flavia Prodam2 -- INTRODUCTION -- CHILDHOOD OBESITY: PATHOLOGICAL BASIS -- Genetic Considerations for Childhood Obesity -- Energy Homeostasis Dysregulation -- Pathophysiology of Adipose Tissue -- PROTEOMICS -- Gel Based Methods -- Non Gel Based Methods: Mass Spectrometry (MS) -- Chips -- Challenges -- PROTEOMIC STUDIES OF ADIPOSE TISSUE -- WAT Depots -- WAT Secretome.

BAT -- Stromal-Vascular Fraction (SVF) -- PROTEOMIC STUDIES IN ADIPOCYTES: STEM CELLS AND CELL LINES -- Adipogenesis: Adipo-proteomics -- Murine 3T3-L1 Preadipocytes -- Adipocyte-Derived Stem Cells (ASCs) -- Adipocyte Secretome -- Post-Translational Modifications (PTMs) -- PROTEOMIC PROFILING: TISSUES AND CIRCULATION -- Fetal Programming: Tissue-Specific Biomarkers -- Circulating Biomarkers -- Urine Biomarkers -- OUTLOOKS -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- ABBREVIATIONS -- REFERENCES -- Relationship Between Hormonal Milieu and Oxidative Stress in Childhood Obesity: A Physiopathological Basis for Antioxidant Treatment and Prevention of Cardiovascular Risk -- Antonio Mancini*, Francesco Leo, Chantal Di Segni, Sebastiano Raimondo and Aurora Natalia Rossodivita -- INTRODUCTION -- OBESITY AND OXIDATIVE STRESS -- Hormones and Inflammatory Molecules Produced by or Related to Adipose Tissue -- Oxidative Stress in Childhood Obesity -- HORMONAL REGULATION OF ANTIOXIDANT SYSTEMS AND THEIR DERANGEMENT IN CHILDHOOD OBESITY -- Growth Hormone (GH) -- Thyroid -- Adrenal Glands -- Gonads -- Adipose tissue (Leptin and Kisspeptin) -- ANTIOXIDANT-ENRICHED DIET AS A TREATMENT FOR OBESITY -- CONCLUSION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- The Role of Gut Microflora in Obesity - Does the Data Provide an Option for Intervention? -- Parth J. Parekh1, Edward C. Oldfield, IV2, Amrit Lamba3 and David A. Johnson4,* -- INTRODUCTION -- OBESITY AND THE MICROFLORA: A BRIEF OVERVIEW -- DATA AND OPTIONS FOR INTERVENTION -- Antibiotics -- Probiotics -- Prebiotics -- Synbiotics -- The Role of Fecal Transplant -- CONCLUSION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- SUBJECT INDEX.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.